Directed phenotype switching as an effective antimelanoma strategy

Therapeutic resistance in melanoma and other cancers arises via irreversible genetic, and dynamic phenotypic, heterogeneity. Here, we use directed phenotype switching in melanoma to sensitize melanoma cells to lineage-specific therapy. We show that methotrexate (MTX) induces microphthalmia-associate...

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Bibliographic Details

Published in:	Cancer cell Vol. 24; no. 1; p. 105
Main Authors:	Sáez-Ayala, Magalí, Montenegro, María F, Sánchez-Del-Campo, Luis, Fernández-Pérez, María Piedad, Chazarra, Soledad, Freter, Rasmus, Middleton, Mark, Piñero-Madrona, Antonio, Cabezas-Herrera, Juan, Goding, Colin R, Rodríguez-López, José Neptuno
Format:	Journal Article
Language:	English
Published:	United States 08.07.2013
Subjects:	Apoptosis - drug effects Catechin - analogs & derivatives Catechin - pharmacology Cell Differentiation - drug effects Cell Line, Tumor DNA Damage E2F1 Transcription Factor - physiology Humans Melanoma - drug therapy Melanoma - pathology Methotrexate - pharmacology Microphthalmia-Associated Transcription Factor - genetics Phenotype Thymine Nucleotides - metabolism
ISSN:	1878-3686, 1878-3686
Online Access:	Get more information
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