Directed phenotype switching as an effective antimelanoma strategy

Therapeutic resistance in melanoma and other cancers arises via irreversible genetic, and dynamic phenotypic, heterogeneity. Here, we use directed phenotype switching in melanoma to sensitize melanoma cells to lineage-specific therapy. We show that methotrexate (MTX) induces microphthalmia-associate...

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Vydáno v:	Cancer cell Ročník 24; číslo 1; s. 105
Hlavní autoři:	Sáez-Ayala, Magalí, Montenegro, María F, Sánchez-Del-Campo, Luis, Fernández-Pérez, María Piedad, Chazarra, Soledad, Freter, Rasmus, Middleton, Mark, Piñero-Madrona, Antonio, Cabezas-Herrera, Juan, Goding, Colin R, Rodríguez-López, José Neptuno
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 08.07.2013
Témata:	Apoptosis - drug effects Catechin - analogs & derivatives Catechin - pharmacology Cell Differentiation - drug effects Cell Line, Tumor DNA Damage E2F1 Transcription Factor - physiology Humans Melanoma - drug therapy Melanoma - pathology Methotrexate - pharmacology Microphthalmia-Associated Transcription Factor - genetics Phenotype Thymine Nucleotides - metabolism
ISSN:	1878-3686, 1878-3686
On-line přístup:	Zjistit podrobnosti o přístupu
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