Highly efficient generation of glutamatergic/cholinergic NT2-derived postmitotic human neurons by short-term treatment with the nucleoside analogue cytosine β-d-arabinofuranoside

The human NTERA2/D1 (NT2) cells generate postmitotic neurons (NT2N cells) upon retinoic acid (RA) treatment and are functionally integrated in the host tissue following grafting into the rodent and human brain, thus representing a promising source for neuronal replacement therapy. Yet the major limi...

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Bibliographic Details
Published in:	Stem cell research Vol. 16; no. 2; pp. 541 - 551
Main Authors:	González-Burguera, Imanol, Ricobaraza, Ana, Aretxabala, Xabier, Barrondo, Sergio, García del Caño, Gontzal, López de Jesús, Maider, Sallés, Joan
Format:	Journal Article
Language:	English
Published:	England Elsevier B.V 01.03.2016 Elsevier
Subjects:	Animals Blotting, Western Brain - metabolism Cell Differentiation - drug effects Cell Line, Tumor Cell Proliferation - drug effects Choline O-Acetyltransferase - metabolism Cholinergic Neurons - cytology Cholinergic Neurons - drug effects Cholinergic Neurons - metabolism Cytarabine - pharmacology Cytosine β-d-arabinofuranoside Glutamate Decarboxylase - metabolism Humans Microscopy, Fluorescence Neurogenesis - drug effects Neuronal differentiation Neurotransmitter phenotype Pluripotent NT2 cells Postmitotic human neurons Rats Retinoic acid Tyrosine 3-Monooxygenase - metabolism Vesicular Glutamate Transport Protein 1 - metabolism Neuronal differentiation Postmitotic human neurons Cytosine β-d-arabinofuranoside Pluripotent NT2 cells Retinoic acid Neurotransmitter phenotype
ISSN:	1873-5061, 1876-7753, 1876-7753
Online Access:	Get full text
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