The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL

The low-density lipoprotein (LDL) receptor (LDLR) is a central determinant of circulating LDL-cholesterol and as such subject to tight regulation. Recent studies and genetic evidence implicate the inducible degrader of the LDLR (IDOL) as a regulator of LDLR abundance and of circulating levels of LDL...

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Veröffentlicht in:	Circulation research Jg. 118; H. 3; S. 410 - 419
Hauptverfasser:	Nelson, Jessica Kristine, Sorrentino, Vincenzo, Avagliano Trezza, Rossella, Heride, Claire, Urbe, Sylvie, Distel, Ben, Zelcer, Noam
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 05.02.2016
Schlagworte:	Animals Cholesterol, LDL - metabolism Endopeptidases - genetics Endopeptidases - metabolism Enzyme Stability HEK293 Cells HeLa Cells Hep G2 Cells Humans Mice, Knockout Multienzyme Complexes Protein Binding Proteolysis Receptors, LDL - genetics Receptors, LDL - metabolism RNA Interference Transfection Ubiquitin-Protein Ligases - deficiency Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination E3 ubiquitin ligase LDL cholesterol MYLIP/IDOL ubiquitin LDL receptors USP2
ISSN:	1524-4571
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