Global left atrial failure in heart failure

The left atrium plays an important role in the maintenance of cardiovascular and neurohumoral homeostasis in heart failure. However, with progressive left ventricular dysfunction, left atrial (LA) dilation and mechanical failure develop, which frequently culminate in atrial fibrillation. Moreover, L...

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Bibliographic Details
Published in:European journal of heart failure Vol. 18; no. 11; pp. 1307 - 1320
Main Authors: Triposkiadis, Filippos, Pieske, Burkert, Butler, Javed, Parissis, John, Giamouzis, Gregory, Skoularigis, John, Brutsaert, Dirk, Boudoulas, Harisios
Format: Journal Article
Language:English
Published: Oxford, UK John Wiley & Sons, Ltd 01.11.2016
Subjects:
Atrial Fibrillation - etiology
Atrial Fibrillation - physiopathology
Atrial Function, Left
Atrial Natriuretic Factor - metabolism
Dilatation
Heart Atria - metabolism
Heart Atria - physiopathology
Heart failure
Heart Failure - metabolism
Heart Failure - physiopathology
Humans
Left atrium
Natriuretic peptide
Sympathetic Nervous System - physiopathology
Vasoconstriction
Vasopressins - metabolism
Ventricular Dysfunction, Left - complications
Ventricular Dysfunction, Left - physiopathology
Heart failure
Left atrium
Dilatation
Natriuretic peptide
ISSN:1388-9842, 1879-0844
Online Access:Get full text
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Summary:The left atrium plays an important role in the maintenance of cardiovascular and neurohumoral homeostasis in heart failure. However, with progressive left ventricular dysfunction, left atrial (LA) dilation and mechanical failure develop, which frequently culminate in atrial fibrillation. Moreover, LA mechanical failure is accompanied by LA endocrine failure [deficient atrial natriuretic peptide (ANP) processing‐synthesis/development of ANP resistance) and LA regulatory failure (dominance of sympathetic nervous system excitatory mechanisms, excessive vasopressin release) contributing to neurohumoral overactivity, vasoconstriction, and volume overload (global LA failure). The purpose of the present review is to describe the characteristics and emphasize the clinical significance of global LA failure in patients with heart failure.
Bibliography:istex:833E36D1EECDD8EFED96E098C9006C51FD1D988C
ark:/67375/WNG-39LKCSN8-2
ArticleID:EJHF645
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1388-9842
1879-0844
DOI:10.1002/ejhf.645