Value of integrated PET-IVIM MRI in predicting Ki-67 expression in newly diagnosed prostate cancer

Accurate assessment of Ki-67 expression in patients with prostate cancer (PC) is paramount. Therefore, this study aimed to assess the value of integrated Gallium-68( 68 Ga)-prostate-Specific membrane antigen-11 (PSMA) Positron Emission Tomography/Intravoxel Incoherent Motion Magnetic Resonance Imagi...

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Vydáno v:Scientific reports Ročník 15; číslo 1; s. 22376 - 6
Hlavní autoři: Xiao, Liu, Li, Yuhao, Xing, Yikai, Li, Lin
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 01.07.2025
Nature Publishing Group
Nature Portfolio
Témata:
631/337
631/67
692/308
692/4025
Aged
Aged, 80 and over
Cancer
Diffusion coefficient
Gallium
Gallium Isotopes
Gallium Radioisotopes
Humanities and Social Sciences
Humans
Immunohistochemistry
IVIM
Ki-67 Antigen - metabolism
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Middle Aged
Mortality
multidisciplinary
Patients
Positron emission tomography
Positron-Emission Tomography - methods
Prostate cancer
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - diagnostic imaging
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
Retrospective Studies
Risk groups
Sarcoma
Science
Science (multidisciplinary)
SUVmax
Immunohistochemistry
SUVmax
IVIM
Prostate cancer
ISSN:2045-2322, 2045-2322
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Shrnutí:Accurate assessment of Ki-67 expression in patients with prostate cancer (PC) is paramount. Therefore, this study aimed to assess the value of integrated Gallium-68( 68 Ga)-prostate-Specific membrane antigen-11 (PSMA) Positron Emission Tomography/Intravoxel Incoherent Motion Magnetic Resonance Imaging (PET/IVIM MRI) in predicting Ki-67 expression in newly diagnosed PC. A retrospective analysis was conducted on 37 newly diagnosed PC patients who underwent 68 Ga-PSMA-11 PET/MR for staging. Maximum Standardized Uptake Value( SUVmax) and IVIM parameters of lesions were quantified. Patients were stratified into low-risk (Ki-67 < 5%) and high-risk groups (Ki-67 > 5%). SUVmax and IVIM parameters were compared between the two groups. Of the 37 patients, 29 were categorized as high risk, while 8 were classified as low risk. The high-risk group exhibited significantly higher SUV max (21.4 ± 11.3 vs. 11.2 ± 8.5, P  = 0.025) and lower Standard apparent diffusion coefficient (ADC) (0.0011 ± 0.00023 vs. 0.0014 ± 0.00039, P  = 0.005) compared to the low-risk group. Receiver operating characteristic (ROC) analysis determined optimal cut-off values for predicting high-risk patients as 7.64 for SUV max (sensitivity: 96.6%, specificity: 59.1%) and 0.0013 for standard ADC (sensitivity: 89.7%, specificity: 52.3%). Integrated assessment of SUVmax and standard ADC using 68 Ga-PSMA-11 PET-IVIM MRI may aid in predicting Ki-67 expression, with optimal thresholds of 7.67 for SUVmax and 0.0013 for standard ADC. These findings offer novel insights into evaluating the biological behavior of prostate cancer tumors in patients undergoing PET/MR imaging.
Bibliografie:ObjectType-Article-1
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-025-02467-0