Tracking the re-emergence of epidemic chikungunya virus in Indonesia

Twenty-four distinct outbreaks of probable chikungunya (CHIK) etiology were identified throughout Indonesia from September 2001 to March 2003, after a near 20-year hiatus of epidemic CHIK activity in the country. Thirteen outbreak reports were based on clinical observations alone, and 11 confirmed b...

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Bibliographic Details
Published in:Transactions of the Royal Society of Tropical Medicine and Hygiene Vol. 99; no. 2; p. 128
Main Authors: Laras, Kanti, Sukri, Nono C, Larasati, Ria P, Bangs, Michael J, Kosim, Rizal, Djauzi, Wandra, Tony, Master, John, Kosasih, Herman, Hartati, Sri, Beckett, Charmagne, Sedyaningsih, Endang R, Beecham, 3rd, H James, Corwin, Andrew L
Format: Journal Article
Language:English
Published: England 01.02.2005
Subjects:
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Alphavirus Infections - epidemiology
Alphavirus Infections - immunology
Antibodies, Viral - blood
Chikungunya virus - immunology
Chikungunya virus - isolation & purification
Child
Child, Preschool
Disease Outbreaks
Humans
Immunoglobulin G - blood
Immunoglobulin M - blood
Indonesia - epidemiology
Middle Aged
Reverse Transcriptase Polymerase Chain Reaction - methods
Risk Factors
RNA, Viral - analysis
Seasons
Indonesia
ISSN:0035-9203
Online Access:Get more information
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Summary:Twenty-four distinct outbreaks of probable chikungunya (CHIK) etiology were identified throughout Indonesia from September 2001 to March 2003, after a near 20-year hiatus of epidemic CHIK activity in the country. Thirteen outbreak reports were based on clinical observations alone, and 11 confirmed by serological/virological methods. Detailed epidemiological profiles of two investigated outbreaks in Bogor and Bekasi are presented. Human sera were screened using an ELISA for IgM and IgG anti-CHIK antibodies. Additionally, reverse transcriptase PCR and virus isolation were attempted for virus identification. The mean age of cases was 37 +/- 18 years in Bogor and 33 +/- 20 years in Bekasi. There was no outstanding case-clustering, although outbreak-affected households were observed to be geographically grouped within villages. The attack rates in Bogor and Bekasi were 2.8/1000 and 6.7/1000 inhabitants respectively. Both outbreaks started in the rainy season following increased Aedes aegypti and A. albopictus densities.
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ISSN:0035-9203
DOI:10.1016/j.trstmh.2004.03.013