Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis

Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality. Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone. Bi-directional Mendelian randomization (MR) analysis on prospe...

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Bibliographic Details
Published in:	PloS one Vol. 12; no. 4; p. e0176277
Main Authors:	Eriksson, Joel, Haring, Robin, Grarup, Niels, Vandenput, Liesbeth, Wallaschofski, Henri, Lorentzen, Erik, Hansen, Torben, Mellström, Dan, Pedersen, Oluf, Nauck, Matthias, Lorentzon, Mattias, Nystrup Husemoen, Lise Lotte, Völzke, Henry, Karlsson, Magnus, Baumeister, Sebastian E., Linneberg, Allan, Ohlsson, Claes
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 2017 Public Library of Science (PLoS)
Subjects:	Adolescent Adult Aged Androgens Biology and Life Sciences Body mass Body Mass Index Body size Body weight Clinical Medicine Consortia elderly-men fto gene Genetic Predisposition to Disease genome-wide association hormone-binding globulin Humans hypogonadotropic hypogonadism Klinisk medicin Male Medicine and Health Sciences Men Mendelian Randomization Analysis Meta-analysis metabolic syndrome muscle strength Obesity Obesity - blood Obesity - genetics older men Phenotype Physical Sciences Polymorphism, Single Nucleotide Preventive medicine Randomization Research and Analysis Methods risk-factors Science & Technology - Other Topics Ships Single-nucleotide polymorphism Smoking Social Sciences Studies Testosterone Testosterone - blood Weight reduction Young Adult Denmark Sweden Germany
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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