Immune correlates analysis of mRNA-1345 RSV vaccine efficacy clinical trial

Identifying an immunologic marker as a correlate of protection (CoP) for RSV vaccination is important. In the pivotal phase 3 trial, the mRNA-1345 vaccine demonstrated efficacy against RSV in older adults (NCT05127434). Here, we evaluate neutralizing antibodies (nAb) against RSV-A and -B, and IgG bi...

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Bibliographic Details
Published in:	Nature communications Vol. 16; no. 1; pp. 6118 - 12
Main Authors:	Ma, Chong, Du, Jiejun, Lan, Lan, Kapoor, Archana, Marc, Gonzalo Perez, Jimenez, Gilberto, Duncan, Christopher J. A., Le Cam, Nancy, Lin, Nina, Priddy, Frances, Garg, Sanjay, Stoszek, Sonia K., Shaw, Christine A., Goswami, Jaya, Wilson, Eleanor, Das, Rituparna, Zhou, Honghong, Zheng, Lingyi
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 03.07.2025 Nature Publishing Group Nature Portfolio
Subjects:	13/1 631/250/255/2514 631/250/590/2293 Adult Aged Antibodies Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Viral - blood Antibodies, Viral - immunology Binding Biomarkers Correlation Effectiveness Female Humanities and Social Sciences Humans Immunoglobulin G Immunoglobulin G - blood Immunoglobulin G - immunology Male Middle Aged mRNA mRNA Vaccines multidisciplinary Neutralizing Older people Respiratory diseases Respiratory syncytial virus Respiratory Syncytial Virus Infections - immunology Respiratory Syncytial Virus Infections - prevention & control Respiratory Syncytial Virus Infections - virology Respiratory Syncytial Virus Vaccines - administration & dosage Respiratory Syncytial Virus Vaccines - immunology Respiratory Syncytial Virus, Human - immunology Respiratory tract Respiratory tract diseases Science Science (multidisciplinary) Vaccine Efficacy Vaccines
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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