From precision interventions to precision health

Precision medicines, or those medicines that are tailored to individual genetic, molecular, physiologic, behavioral, and/or exposure profiles, are being developed at a rapid pace. However, just how precise these interventions are in terms of their mechanisms of action (MOAs), clinical effects, and u...

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Veröffentlicht in:Nature communications Jg. 16; H. 1; S. 5024 - 11
Hauptverfasser: Schork, Nicholas J., Goetz, Laura H.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 30.05.2025
Nature Publishing Group
Nature Portfolio
Schlagworte:
692/308/575
692/700/1538
Agonists
Animals
Clinical trials
Clinical Trials as Topic
Cytotoxicity
Genetic diversity
Humanities and Social Sciences
Humans
Intervention
multidisciplinary
Perspective
Phenotypes
Phenotyping
Physiology
Precision medicine
Precision Medicine - methods
Precision Medicine - trends
Science
Science (multidisciplinary)
Weight control
ISSN:2041-1723, 2041-1723
Online-Zugang:Volltext
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Zusammenfassung:Precision medicines, or those medicines that are tailored to individual genetic, molecular, physiologic, behavioral, and/or exposure profiles, are being developed at a rapid pace. However, just how precise these interventions are in terms of their mechanisms of action (MOAs), clinical effects, and utility in different individuals, are hard anticipate with current preclinical research and clinical trials strategies. To understand how various genes, processes, organs, clinical phenotypes, etc. may be impacted by an intervention, as well as how many people might benefit from it, appropriate data on living human beings needs to be collected as part of built-for-purpose clinical trials. We consider the shift from broad, population-level medicine to ultra-precise, individualized medicine using emerging therapeutic constructs, AI, deep phenotyping, and individual-centered trials to optimize health across diverse individual genetic and physiological profiles.
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-025-60395-z