Divergent therapeutic and prognostic impacts of immunogenic features in undifferentiated pleomorphic sarcoma and myxofibrosarcoma

Undifferentiated pleomorphic sarcoma (UPS) and myxofibrosarcoma (MFS) are genetically complex soft tissue sarcomas with distinct morphological features. Treatment typically involves surgery, often combined with neoadjuvant chemo- or radiotherapy. To better understand the immunobiology of these sarco...

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Bibliographic Details
Published in:	Cancer Immunology, Immunotherapy : CII Vol. 74; no. 8; pp. 258 - 14
Main Authors:	van Oost, Siddh, Meijer, Debora M., Erdem, Zeynep B., IJsselsteijn, Marieke E., Roelands, Jessica, Lam, Suk Wai, Boejharat, Melissa S., van den Akker, Brendy E. W. M., van der Breggen, Ruud, Briare-de Bruijn, Inge H., Hawinkels, Lukas J. A. C., Kruiswijk, Anouk A., van der Ploeg, Manon, Wijers-Koster, Pauline M., Haas, Rick L., van den Sande, Michiel A. J., de Miranda, Noel F. C. C., Bovee, Judith V. M. G.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 02.07.2025 Springer Nature B.V Springer
Subjects:	Adult Aged Antibodies Antigens Biomarkers, Tumor - genetics Biopsy Cancer Research CD163 antigen Cytotoxicity Datasets Female Fibrosarcoma - genetics Fibrosarcoma - immunology Fibrosarcoma - mortality Fibrosarcoma - pathology Fibrosarcoma - therapy Gene expression Genomes Humans Immune microenvironment Immunofluorescence Immunogenicity Immunology Infiltration Lymphocytes T Lymphocytes, Tumor-Infiltrating - immunology Macrophages Macrophages - immunology Male Medicine Medicine & Public Health Metastases Metastasis-free survival Middle Aged Myeloid cells Myxofibrosarcomas Oncology Patients Prognosis Radiation therapy Radiotherapy Sarcoma Sarcoma - genetics Sarcoma - immunology Sarcoma - pathology Sarcoma - therapy Soft tissue sarcoma Transcriptomics Tumor Microenvironment - immunology Tumors Undifferentiated pleomorphic sarcomas Netherlands Immune microenvironment Radiotherapy Undifferentiated pleomorphic sarcomas Myxofibrosarcomas Metastasis-free survival
ISSN:	1432-0851, 0340-7004, 1432-0851
Online Access:	Get full text
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