Oncogenic Integration of Nucleotide Metabolism via Fatty Acid Synthase in Non-Hodgkin Lymphoma

Metabolic dysfunctions enabling increased nucleotide biosynthesis are necessary for supporting malignant proliferation. Our investigations indicate that upregulation of fatty acid synthase (FASN) and de novo lipogenesis, commonly observed in many cancers, are associated with nucleotide metabolic dys...

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Bibliographic Details
Published in:	Frontiers in oncology Vol. 11; p. 725137
Main Authors:	Ravi, Dashnamoorthy, Beheshti, Afshin, Abermil, Nasséra, Lansigan, Frederick, Kinlaw, William, Matthan, Nirupa R., Mokhtar, Maisarah, Passero, Frank C., Puliti, Patrick, David, Kevin A., Dolnikowski, Gregory G., Su, Xiaoyang, Chen, Ying, Bijan, Mahboubi, Varshney, Rohan R., Kim, Baek, Dave, Sandeep S., Rudolph, Michael C., Evens, Andrew M.
Format:	Journal Article
Language:	English
Published:	Ames Research Center Frontiers Media 26.10.2021 Frontiers Media S.A
Subjects:	Aerospace Medicine FASN Human health and pathology Life Sciences lipid metabolism metabolomics non-Hodgkin lymphoma nucleotides Oncology pentose phosphate pathway Lipid Metabolism Non-Hodgkin Lymphoma Nucleotides Fasn, Metabolomics Pentose Phosphate Pathway non-Hodgkin lymphoma metabolomics nucleotides FASN pentose phosphate pathway lipid metabolism
ISSN:	2234-943X, 2234-943X
Online Access:	Get full text
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