CD44 is required for the pathogenesis of experimental crescentic glomerulonephritis and collapsing focal segmental glomerulosclerosis

A key feature of glomerular diseases such as crescentic glomerulonephritis and focal segmental glomerulosclerosis is the activation, migration and proliferation of parietal epithelial cells. CD44-positive activated parietal epithelial cells have been identified in proliferative cellular lesions in g...

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Veröffentlicht in:	Kidney international Jg. 93; H. 3; S. 626
Hauptverfasser:	Eymael, Jennifer, Sharma, Shagun, Loeven, Markus A, Wetzels, Jack F, Mooren, Fieke, Florquin, Sandrine, Deegens, Jeroen K, Willemsen, Brigith K, Sharma, Vikram, van Kuppevelt, Toin H, Bakker, Marinka A, Ostendorf, Tammo, Moeller, Marcus J, Dijkman, Henry B, Smeets, Bart, van der Vlag, Johan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.03.2018
Schlagworte:	Albuminuria - genetics Albuminuria - immunology Albuminuria - metabolism Animals Anti-Glomerular Basement Membrane Disease - genetics Anti-Glomerular Basement Membrane Disease - immunology Anti-Glomerular Basement Membrane Disease - metabolism Anti-Glomerular Basement Membrane Disease - pathology Autoantibodies - immunology Cell Movement Cell Proliferation Cells, Cultured Disease Models, Animal Epithelial Cells - immunology Epithelial Cells - metabolism Epithelial Cells - pathology Extracellular Matrix Proteins - metabolism Genetic Predisposition to Disease Glomerulosclerosis, Focal Segmental - genetics Glomerulosclerosis, Focal Segmental - immunology Glomerulosclerosis, Focal Segmental - metabolism Glomerulosclerosis, Focal Segmental - pathology Granulocytes - immunology Granulocytes - metabolism Hyaluronan Receptors - genetics Hyaluronan Receptors - immunology Hyaluronan Receptors - metabolism Kidney Glomerulus - immunology Kidney Glomerulus - metabolism Kidney Glomerulus - pathology Macrophages - immunology Macrophages - metabolism Mice, Inbred C57BL Mice, Knockout Phenotype Signal Transduction Thy-1 Antigens - genetics Thy-1 Antigens - immunology Thy-1 Antigens - metabolism cell migration parietal epithelial cells collapsing FSGS crescentic glomerulonephritis CD44
ISSN:	1523-1755, 1523-1755
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