Reactive oxygen species in cardiovascular disease

Based on the “free radical theory” of disease, researchers have been trying to elucidate the role of oxidative stress from free radicals in cardiovascular disease. Considerable data indicate that reactive oxygen species and oxidative stress are important features of cardiovascular diseases including...

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Bibliographic Details
Published in:	Free radical biology & medicine Vol. 51; no. 5; pp. 978 - 992
Main Authors:	Sugamura, Koichi, Keaney, John F.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.09.2011
Subjects:	Animals antioxidants Antioxidants - therapeutic use atherosclerosis Biomarkers Biomarkers - metabolism Cardiovascular disease Cardiovascular Diseases - drug therapy Cardiovascular Diseases - metabolism Cardiovascular Diseases - physiopathology cardiovascular system Clinical trials Clinical Trials as Topic Free radicals Heart - drug effects Heart - physiology heart failure Humans hypertension Molecular Targeted Therapy - trends oxidative stress Oxidative Stress - drug effects pathophysiology physiology Reactive oxygen species Reactive Oxygen Species - metabolism NADPH eNOS RCT Reactive oxygen species 5-LO BH 4 Clinical trials Cardiovascular disease LV MPO 12/15-LO HDL Mn-SOD LDL LDL-R iNOS ApoE MI PROBE Free radicals 12-LO CAD ox-LDL GCH CVD ACS 5-MTHF NOS ApoA-I nNOS ROS Biomarkers GPX-1 CHD HF
ISSN:	0891-5849, 1873-4596, 1873-4596
Online Access:	Get full text
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Summary:	Based on the “free radical theory” of disease, researchers have been trying to elucidate the role of oxidative stress from free radicals in cardiovascular disease. Considerable data indicate that reactive oxygen species and oxidative stress are important features of cardiovascular diseases including atherosclerosis, hypertension, and congestive heart failure. However, blanket strategies with antioxidants to ameliorate cardiovascular disease have not generally yielded favorable results. However, our understanding of reactive oxygen species has evolved to the point at which we now realize these species have important roles in physiology as well as pathophysiology. Thus, it is overly simplistic to assume a general antioxidant strategy will yield specific effects on cardiovascular disease. Indeed, there are several sources of reactive oxygen species that are known to be active in the cardiovascular system. This review addresses our understanding of reactive oxygen species sources in cardiovascular disease and both animal and human data defining how reactive oxygen species contribute to physiology and pathology.
Bibliography:	http://dx.doi.org/10.1016/j.freeradbiomed.2011.05.004 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Review-3
ISSN:	0891-5849 1873-4596 1873-4596
DOI:	10.1016/j.freeradbiomed.2011.05.004