Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study

Progressive disability in multiple sclerosis occurs because CNS axons degenerate as a late consequence of demyelination. In animals, retinoic acid receptor RXR-gamma agonists promote remyelination. We aimed to assess the safety and efficacy of a non-selective retinoid X receptor agonist in promoting...

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Bibliographic Details
Published in:	Lancet neurology Vol. 20; no. 9; pp. 709 - 720
Main Authors:	Brown, J William L, Cunniffe, Nick G, Prados, Ferran, Kanber, Baris, Jones, Joanne L, Needham, Edward, Georgieva, Zoya, Rog, David, Pearson, Owen R, Overell, James, MacManus, David, Samson, Rebecca S, Stutters, Jonathan, ffrench-Constant, Charles, Gandini Wheeler-Kingshott, Claudia A M, Moran, Carla, Flynn, Paul D, Michell, Andrew W, Franklin, Robin J M, Chandran, Siddharthan, Altmann, Daniel R, Chard, Declan T, Connick, Peter, Coles, Alasdair J
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.09.2021 Elsevier Limited
Subjects:	Acids Adult Adverse events Agonists Axons Bexarotene - administration & dosage Bexarotene - adverse effects Bexarotene - pharmacology Cholecystitis Clinical trials Demyelination Disability Double-Blind Method Double-blind studies Drug-Related Side Effects and Adverse Reactions Evoked Potentials, Visual - physiology Female Humans Hypothyroidism Licenses Magnetic Resonance Imaging Male Middle Aged Multiple sclerosis Multiple Sclerosis, Relapsing-Remitting - diagnostic imaging Multiple Sclerosis, Relapsing-Remitting - drug therapy Multiple Sclerosis, Relapsing-Remitting - physiopathology Myelination Neutropenia Outcome Assessment, Health Care Patients Placebos Remyelination - drug effects Retinoid X receptors Retinoid X Receptors - agonists Safety Statistical analysis United Kingdom > UK
ISSN:	1474-4422, 1474-4465, 1474-4465
Online Access:	Get full text
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