Role of prokineticins and T-reg cells in obesity-associated metabolic oxidative dysregulation in NAFLD

We investigate the role of prokineticin, T-reg cells, and oxidative metabolism in the progression of obesity-related NASH to HCC. Our findings on a cohort of 250 patients, including Obese NAFLD and Non-Obese NAFLD, reveal significant insights. In Obese NAFLD, PK-1 mRNA expression was reduced by 2.4-...

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Bibliographic Details
Published in:	Scientific reports Vol. 15; no. 1; pp. 29470 - 14
Main Authors:	Prakash, Shyam, Priyatma, Aasarey, Ram, Khan, Shahid, Vikram, Naval K., Shalimar, Medha, Srivastava, Saumya, Pandey, Shivam, Priya, Akanksha, Aggarwal, Sandeep
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 12.08.2025 Nature Publishing Group Nature Portfolio
Subjects:	692/4017 692/4020 692/53 Adipocytes Adult Blood diseases Blood pressure Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology CD4 antigen CD8 antigen Correlation analysis Cytokines Diabetes Enzymes Fatty acid-binding protein Fatty acids Fatty liver Female Flow cytometry GA-binding protein Gastrointestinal Hormones - genetics Gastrointestinal Hormones - metabolism Gene expression Glucose High density lipoprotein Humanities and Social Sciences Humans Hypertension Immunomodulation Interleukin 10 Interleukin-10 - genetics Interleukin-10 - metabolism Liver cirrhosis Liver diseases Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Metabolic disorders Metabolic syndrome Middle Aged multidisciplinary Neuropeptides Non-alcoholic Fatty Liver Disease - etiology Non-alcoholic Fatty Liver Disease - immunology Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology Obesity Obesity - complications Obesity - immunology Obesity - metabolism Overweight Oxidative metabolism Oxidative Stress Patients Plasma Science Science (multidisciplinary) Standard scores Therapeutic targets Vascular Endothelial Growth Factor, Endocrine-Gland-Derived - genetics Vascular Endothelial Growth Factor, Endocrine-Gland-Derived - metabolism Womens health
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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