Amitriptyline at Low-Dose and Titrated for Irritable Bowel Syndrome as Second-Line Treatment in primary care (ATLANTIS): a randomised, double-blind, placebo-controlled, phase 3 trial

Most patients with irritable bowel syndrome (IBS) are managed in primary care. When first-line therapies for IBS are ineffective, the UK National Institute for Health and Care Excellence guideline suggests considering low- dose tricyclic antidepressants as second-line treatment, but their effectiven...

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Bibliographic Details
Published in:	The Lancet (British edition) Vol. 402; no. 10414; pp. 1773 - 1785
Main Authors:	Ford, Alexander C, Wright-Hughes, Alexandra, Alderson, Sarah L, Ow, Pei-Loo, Ridd, Matthew J, Foy, Robbie, Bianco, Gina, Bishop, Felicity L, Chaddock, Matthew, Cook, Heather, Cooper, Deborah, Fernandez, Catherine, Guthrie, Elspeth A, Hartley, Suzanne, Herbert, Amy, Howdon, Daniel, Muir, Delia P, Nath, Taposhi, Newman, Sonia, Smith, Thomas, Taylor, Christopher A, Teasdale, Emma J, Thornton, Ruth, Farrin, Amanda J, Everitt, Hazel A, Ford, Alexander C., Wright-Hughes, Alex, Alderson, Sarah L., Ridd, Matthew J., Barratt, Maggie, Bishop, Felicity L., Brindle, Richard, Brown, Sarah, Christodoulou, Aimee, Day, Florence, Dowse, Aaron, Durnell, Jill, Emmerson, Jake, Fellows, Alasdair, Guthrie, Elspeth A., Hindmarch, Damien, Malik, Aminah, Morris, Tom, Muir, Delia P., Longo, Roberta, Lopes Goncalves Graca, Sandra, Parker, Catriona, Taylor, Christopher A., Teasdale, Emma J., Tubeuf, Sandy, West, Amy, Williamson, Emma-Jane, Farrin, Amanda J., Everitt, Hazel A.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 11.11.2023 Elsevier Limited
Subjects:	Adverse events Amitriptyline Amitriptyline - adverse effects Antidepressants C-reactive protein Disease Double-Blind Method Double-blind studies Drug dosages Effectiveness England Female Health care Humans Informed consent Intestine Irritable bowel syndrome Irritable Bowel Syndrome - drug therapy Laxatives Male Middle Aged Pandemics Placebos Primary care Primary Health Care Quality of life Serology Technology assessment Titration Treatment Outcome Tricyclic antidepressants England United Kingdom > UK United States > US
ISSN:	0140-6736, 1474-547X, 1474-547X
Online Access:	Get full text
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