The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects

The ability of ketamine administration to activate prefrontal glutamate neurotransmission is thought to be a key mechanism contributing to its transient psychotomimetic effects and its delayed and sustained antidepressant effects. Rodent studies employing carbon-13 magnetic resonance spectroscopy (...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) Jg. 43; H. 10; S. 2154 - 2160
Hauptverfasser:	Abdallah, Chadi G, De Feyter, Henk M, Averill, Lynnette A, Jiang, Lihong, Averill, Christopher L, Chowdhury, Golam M I, Purohit, Prerana, de Graaf, Robin A, Esterlis, Irina, Juchem, Christoph, Pittman, Brian P, Krystal, John H, Rothman, Douglas L, Sanacora, Gerard, Mason, Graeme F
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Nature Publishing Group 01.09.2018
Schlagworte:	Adult Aged Antidepressive Agents - pharmacology Carbon 13 Cortex (frontal) Depressive Disorder - physiopathology Energy Metabolism - drug effects Excitatory Amino Acid Antagonists - pharmacology Female Glutamate receptors Glutamates - physiology Glutamic acid receptors (ionotropic) Glutamine Hallucinogens - pharmacology Healthy Volunteers Humans Ketamine Ketamine - pharmacology Magnetic Resonance Spectroscopy Male Mental disorders Middle Aged N-Methyl-D-aspartic acid receptors Neurotransmission Pilot Projects Prefrontal cortex Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Rodents Schizophrenia Synaptic Transmission - drug effects Young Adult
ISSN:	0893-133X, 1740-634X, 1740-634X
Online-Zugang:	Volltext
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