Concussion causes transient dysfunction in cortical inhibitory networks but not the corpus callosum

The corpus callosum (CC) is thought to be especially vulnerable in traumatic brain injury. Bimanual cost (a slowing of reaction time with bimanual compared to unimanual responses) is a sensitive indicator of CC function. To determine whether CC dysfunction is a significant feature of mild traumatic...

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Published in:	Journal of clinical neuroscience Vol. 17; no. 3; pp. 315 - 319
Main Authors:	Hammond-Tooke, G.D., Goei, J., du Plessis, L.J., Franz, E.A.
Format:	Journal Article
Language:	English
Published:	Scotland Elsevier Ltd 01.03.2010
Subjects:	Adolescent Adult Analysis of Variance Bimanual cost Brain Concussion - complications Brain Concussion - pathology Brain Mapping Cerebral Cortex - physiopathology Cognition Disorders - etiology Cognition Disorders - pathology Concussion Corpus callosum Corpus Callosum - physiopathology Female Functional Laterality - physiology Humans Inhibition (Psychology) Male Neurology Neuropsychological Tests Psychomotor Performance - physiology Reaction Time - physiology Reaction times Surveys and Questionnaires Young Adult Bimanual cost Reaction times Concussion Corpus callosum
ISSN:	0967-5868, 1532-2653, 1532-2653
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Abstract	The corpus callosum (CC) is thought to be especially vulnerable in traumatic brain injury. Bimanual cost (a slowing of reaction time with bimanual compared to unimanual responses) is a sensitive indicator of CC function. To determine whether CC dysfunction is a significant feature of mild traumatic brain injury, unimanual and bimanual reaction times were studied in 10 recently concussed patients and 10 healthy participants. Reaction times were studied within 1 week of concussion and again after 1 month. Concussion symptoms were assessed with the Rivermead Postconcussion Symptoms Questionnaire. The bimanual cost was present at both testing sessions in patients and healthy controls. Although overall reaction times were slower in concussed patients during session 1, these had improved by session 2, as did the symptom scores. These findings suggest that the pathogenesis of mild traumatic brain injury involves intrahemispheric cortical networks rather than impaired interhemispheric communication via the CC.
AbstractList	The corpus callosum (CC) is thought to be especially vulnerable in traumatic brain injury. Bimanual cost (a slowing of reaction time with bimanual compared to unimanual responses) is a sensitive indicator of CC function. To determine whether CC dysfunction is a significant feature of mild traumatic brain injury, unimanual and bimanual reaction times were studied in 10 recently concussed patients and 10 healthy participants. Reaction times were studied within 1 week of concussion and again after 1 month. Concussion symptoms were assessed with the Rivermead Postconcussion Symptoms Questionnaire. The bimanual cost was present at both testing sessions in patients and healthy controls. Although overall reaction times were slower in concussed patients during session 1, these had improved by session 2, as did the symptom scores. These findings suggest that the pathogenesis of mild traumatic brain injury involves intrahemispheric cortical networks rather than impaired interhemispheric communication via the CC. The corpus callosum (CC) is thought to be especially vulnerable in traumatic brain injury. Bimanual cost (a slowing of reaction time with bimanual compared to unimanual responses) is a sensitive indicator of CC function. To determine whether CC dysfunction is a significant feature of mild traumatic brain injury, unimanual and bimanual reaction times were studied in 10 recently concussed patients and 10 healthy participants. Reaction times were studied within 1 week of concussion and again after 1 month. Concussion symptoms were assessed with the Rivermead Postconcussion Symptoms Questionnaire. The bimanual cost was present at both testing sessions in patients and healthy controls. Although overall reaction times were slower in concussed patients during session 1, these had improved by session 2, as did the symptom scores. These findings suggest that the pathogenesis of mild traumatic brain injury involves intrahemispheric cortical networks rather than impaired interhemispheric communication via the CC.The corpus callosum (CC) is thought to be especially vulnerable in traumatic brain injury. Bimanual cost (a slowing of reaction time with bimanual compared to unimanual responses) is a sensitive indicator of CC function. To determine whether CC dysfunction is a significant feature of mild traumatic brain injury, unimanual and bimanual reaction times were studied in 10 recently concussed patients and 10 healthy participants. Reaction times were studied within 1 week of concussion and again after 1 month. Concussion symptoms were assessed with the Rivermead Postconcussion Symptoms Questionnaire. The bimanual cost was present at both testing sessions in patients and healthy controls. Although overall reaction times were slower in concussed patients during session 1, these had improved by session 2, as did the symptom scores. These findings suggest that the pathogenesis of mild traumatic brain injury involves intrahemispheric cortical networks rather than impaired interhemispheric communication via the CC. Abstract The corpus callosum (CC) is thought to be especially vulnerable in traumatic brain injury. Bimanual cost (a slowing of reaction time with bimanual compared to unimanual responses) is a sensitive indicator of CC function. To determine whether CC dysfunction is a significant feature of mild traumatic brain injury, unimanual and bimanual reaction times were studied in 10 recently concussed patients and 10 healthy participants. Reaction times were studied within 1 week of concussion and again after 1 month. Concussion symptoms were assessed with the Rivermead Postconcussion Symptoms Questionnaire. The bimanual cost was present at both testing sessions in patients and healthy controls. Although overall reaction times were slower in concussed patients during session 1, these had improved by session 2, as did the symptom scores. These findings suggest that the pathogenesis of mild traumatic brain injury involves intrahemispheric cortical networks rather than impaired interhemispheric communication via the CC.
Author	Goei, J. Hammond-Tooke, G.D. du Plessis, L.J. Franz, E.A.
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Cites_doi	10.1093/brain/awm216 10.3200/JMBR.37.1.3-9 10.1212/WNL.57.3.524 10.1115/1.2834294 10.1016/0028-3932(71)90067-4 10.1111/j.1600-0404.2007.00827.x 10.1007/BF00868811 10.3171/jns.1998.88.5.0795 10.1227/01.NEU.0000118820.33396.6A 10.1037/0894-4105.18.3.564 10.1152/jn.2002.88.2.1051 10.1007/s002210050752 10.3200/JMBR.39.1.3-8 10.1097/00006123-200211000-00011 10.1080/13803390490520328 10.1212/01.wnl.0000305961.68029.54 10.1207/s15324826an1103_2 10.1017/S1355617704105146 10.1016/j.acn.2007.03.004 10.1016/0090-3019(95)00210-3 10.1016/S0301-0082(02)00018-7 10.1111/j.1467-9280.2007.02020.x
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Snippet	The corpus callosum (CC) is thought to be especially vulnerable in traumatic brain injury. Bimanual cost (a slowing of reaction time with bimanual compared to... Abstract The corpus callosum (CC) is thought to be especially vulnerable in traumatic brain injury. Bimanual cost (a slowing of reaction time with bimanual...
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SubjectTerms	Adolescent Adult Analysis of Variance Bimanual cost Brain Concussion - complications Brain Concussion - pathology Brain Mapping Cerebral Cortex - physiopathology Cognition Disorders - etiology Cognition Disorders - pathology Concussion Corpus callosum Corpus Callosum - physiopathology Female Functional Laterality - physiology Humans Inhibition (Psychology) Male Neurology Neuropsychological Tests Psychomotor Performance - physiology Reaction Time - physiology Reaction times Surveys and Questionnaires Young Adult
Title	Concussion causes transient dysfunction in cortical inhibitory networks but not the corpus callosum
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