Concussion causes transient dysfunction in cortical inhibitory networks but not the corpus callosum

The corpus callosum (CC) is thought to be especially vulnerable in traumatic brain injury. Bimanual cost (a slowing of reaction time with bimanual compared to unimanual responses) is a sensitive indicator of CC function. To determine whether CC dysfunction is a significant feature of mild traumatic...

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Bibliographic Details
Published in:Journal of clinical neuroscience Vol. 17; no. 3; pp. 315 - 319
Main Authors: Hammond-Tooke, G.D., Goei, J., du Plessis, L.J., Franz, E.A.
Format: Journal Article
Language:English
Published: Scotland Elsevier Ltd 01.03.2010
Subjects:
Adolescent
Adult
Analysis of Variance
Bimanual cost
Brain Concussion - complications
Brain Concussion - pathology
Brain Mapping
Cerebral Cortex - physiopathology
Cognition Disorders - etiology
Cognition Disorders - pathology
Concussion
Corpus callosum
Corpus Callosum - physiopathology
Female
Functional Laterality - physiology
Humans
Inhibition (Psychology)
Male
Neurology
Neuropsychological Tests
Psychomotor Performance - physiology
Reaction Time - physiology
Reaction times
Surveys and Questionnaires
Young Adult
Bimanual cost
Reaction times
Concussion
Corpus callosum
ISSN:0967-5868, 1532-2653, 1532-2653
Online Access:Get full text
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Summary:The corpus callosum (CC) is thought to be especially vulnerable in traumatic brain injury. Bimanual cost (a slowing of reaction time with bimanual compared to unimanual responses) is a sensitive indicator of CC function. To determine whether CC dysfunction is a significant feature of mild traumatic brain injury, unimanual and bimanual reaction times were studied in 10 recently concussed patients and 10 healthy participants. Reaction times were studied within 1 week of concussion and again after 1 month. Concussion symptoms were assessed with the Rivermead Postconcussion Symptoms Questionnaire. The bimanual cost was present at both testing sessions in patients and healthy controls. Although overall reaction times were slower in concussed patients during session 1, these had improved by session 2, as did the symptom scores. These findings suggest that the pathogenesis of mild traumatic brain injury involves intrahemispheric cortical networks rather than impaired interhemispheric communication via the CC.
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ISSN:0967-5868
1532-2653
1532-2653
DOI:10.1016/j.jocn.2009.06.026