Non-alcoholic fatty liver disease increases risk of carotid atherosclerosis and ischemic stroke: An updated meta-analysis with 135,602 individuals

Background/Aims: Non-alcoholic fatty liver disease (NAFLD) is associated with the development of cardiovascular disease. While existing studies have examined cardiac remodeling in NAFLD, there has been less emphasis on the development of carotid atherosclerosis and stroke. We sought to conduct a met...

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Veröffentlicht in:Clinical and molecular hepatology Jg. 28; H. 3; S. 483 - 496
Hauptverfasser: Tang, Ansel Shao Pin, Chan, Kai En, Quek, Jingxuan, Xiao, Jieling, Tay, Phoebe, Teng, Margaret, Lee, Keng Siang, Lin, Snow Yunni, Myint, May Zin, Tan, Benjamin, Sharma, Vijay K, Tan, Darren Jun Hao, Lim, Wen Hui, Kaewdech, Apichat, Huang, Daniel, Chew, Nicholas WS, Siddiqui, Mohammad Shadab, Sanyal, Arun J, Muthiah, Mark, Ng, Cheng Han
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Seoul Korean Association for the Study of the Liver 01.07.2022
The Korean Association for the Study of the Liver
대한간학회
Schlagworte:
Atherosclerosis
Biopsy
Content analysis
Fatty liver
Histology
Ischemia
ischemic stroke
Liver diseases
Meta-analysis
Metabolism
nonalcoholic fatty liver disease
Original
Risk factors
Statistical analysis
Stroke
Ultrasonic imaging
Veins & arteries
내과학
United States > US
Egypt
ISSN:2287-2728, 2287-285X, 2287-285X
Online-Zugang:Volltext
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Zusammenfassung:Background/Aims: Non-alcoholic fatty liver disease (NAFLD) is associated with the development of cardiovascular disease. While existing studies have examined cardiac remodeling in NAFLD, there has been less emphasis on the development of carotid atherosclerosis and stroke. We sought to conduct a meta-analysis to quantify the prevalence, risk factors, and degree of risk increment of carotid atherosclerosis and stroke in NAFLD.Methods: Embase and Medline were searched for articles relating to NAFLD, carotid atherosclerosis, and stroke. Proportional data was analysed using a generalized linear mixed model. Pairwise meta-analysis was conducted to obtain odds ratio or weighted mean difference for comparison between patients with and without NAFLD.Results: From pooled analysis of 30 studies involving 7,951 patients with NAFLD, 35.02% (95% confidence interval [CI], 27.36–43.53%) had carotid atherosclerosis with an odds ratio of 3.20 (95% CI, 2.37–4.32; P<0.0001). Pooled analysis of 25,839 patients with NAFLD found the prevalence of stroke to be 5.04% (95% CI, 2.74–9.09%) with an odds ratio of 1.88 (95% CI, 1.23–2.88; P=0.02) compared to non-NAFLD. The degree of steatosis assessed by ultrasonography in NAFLD was closely associated with risk of carotid atherosclerosis and stroke. Older age significantly increased the risk of developing carotid atherosclerosis, but not stroke in NAFLD.Conclusions: This meta-analysis shows that a stepwise increment of steatosis of NAFLD can significantly increase the risk of carotid atherosclerosis and stroke development in NAFLD. Patients more than a third sufferred from carotid atherosclerosis and routine assessment of carotid atherosclerosis is quintessential in NAFLD.
Bibliographie:ObjectType-Article-1
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These authors contributed equally to this work as co-first authors.
Editor: Jian-Gao Fan, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, China
ISSN:2287-2728
2287-285X
2287-285X
DOI:10.3350/cmh.2021.0406