Mitochondrial Function and Reactive Oxygen/Nitrogen Species in Skeletal Muscle

Skeletal muscle fibers contain a large number of mitochondria, which produce ATP through oxidative phosphorylation (OXPHOS) and provide energy for muscle contraction. In this process, mitochondria also produce several types of “reactive species” as side product, such as reactive oxygen species and r...

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Veröffentlicht in:Frontiers in cell and developmental biology Jg. 10; S. 826981
Hauptverfasser: Chen, Ming-Ming, Li, Yan, Deng, Shou-Long, Zhao, Yue, Lian, Zheng-Xing, Yu, Kun
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland Frontiers Media SA 21.02.2022
Frontiers Media S.A
Schlagworte:
Atrophy
Cell and Developmental Biology
Cell fate
Dehydrogenases
Enzymes
Glutathione
Homeostasis
Metabolism
Mitochondria
mitochondrial dynamics
mitochondrial function
Muscle contraction
Musculoskeletal system
Myogenesis
Nitric oxide
Nitrogen
Oxidative phosphorylation
Oxidative stress
Phosphorylation
Physiology
Reactive nitrogen species
Reactive oxygen species
Respiration
RONS
Skeletal muscle
Structure-function relationships
mitochondrial function
RONS
skeletal muscle
oxidative stress
mitochondrial dynamics
ISSN:2296-634X, 2296-634X
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Zusammenfassung:Skeletal muscle fibers contain a large number of mitochondria, which produce ATP through oxidative phosphorylation (OXPHOS) and provide energy for muscle contraction. In this process, mitochondria also produce several types of “reactive species” as side product, such as reactive oxygen species and reactive nitrogen species which have attracted interest. Mitochondria have been proven to have an essential role in the production of skeletal muscle reactive oxygen/nitrogen species (RONS). Traditionally, the elevation in RONS production is related to oxidative stress, leading to impaired skeletal muscle contractility and muscle atrophy. However, recent studies have shown that the optimal RONS level under the action of antioxidants is a critical physiological signal in skeletal muscle. Here, we will review the origin and physiological functions of RONS, mitochondrial structure and function, mitochondrial dynamics, and the coupling between RONS and mitochondrial oxidative stress. The crosstalk mechanism between mitochondrial function and RONS in skeletal muscle and its regulation of muscle stem cell fate and myogenesis will also be discussed. In all, this review aims to describe a comprehensive and systematic network for the interaction between skeletal muscle mitochondrial function and RONS.
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Diego De Stefani, University of Padua, Italy
These authors have contributed equally to this work
Reviewed by: Pablo Hernansanz-Agustín, Spanish National Centre for Cardiovascular Research, Spain
This article was submitted to Cellular Biochemistry, a section of the journal Frontiers in Cell and Developmental Biology
Edited by: Luigi M. Terracciano, University of Basel, Switzerland
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2022.826981