Inflammation and structural changes in the airways of patients with primary Sjögren's syndrome

The present study aimed to compare the cellular pattern and structural changes in the airways of patients with primary Sjögren's syndrome (pSS) with healthy controls. Bronchial biopsy specimens were obtained from seven subjects with pSS and seven healthy controls. All the patients with pSS had...

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Bibliographic Details
Published in:Respiratory medicine Vol. 95; no. 11; pp. 904 - 910
Main Authors: AMIN, K., LÚDVÍKSDÓTTIR, D., JANSON, C., NETTELBLADT, O., GUDBJÖRNSSON, B., VALTYSDÓTTIR, S., BJÖRNSSON, E., ROOMANS, G.M., BOMAN, G., SEVÉUS, L., VENGE, P.
Format: Journal Article
Language:English
Published: Oxford Elsevier Ltd 01.11.2001
Elsevier
Subjects:
Adult
Biological and medical sciences
Biopsy - methods
Bronchial Hyperreactivity - complications
Bronchial Hyperreactivity - pathology
Bronchial Provocation Tests
Bronchoconstrictor Agents
bronchoscopy
Case-Control Studies
cytokines
Eosinophils - immunology
Female
Humans
inflammatory cells
Interleukin-4 - immunology
Interleukin-5 - immunology
Interleukin-8 - immunology
laminin
Laminin - analysis
Male
Mast Cells - immunology
Medical sciences
MEDICIN
MEDICINE
Methacholine Chloride
Middle Aged
Neutrophils - immunology
Pneumology
Respiratory system : syndromes and miscellaneous diseases
Sjogren's Syndrome - complications
Sjogren's Syndrome - pathology
Sjögren's syndrome
Statistics, Nonparametric
T-Lymphocytes - immunology
tenascin
Tenascin - analysis
cytokines
laminin
Sjögren's syndrome
tenascin
inflammatory cells
bronchoscopy
Human
Immunohistochemistry
Skin disease
Nervous system diseases
Hyperreactivity
Respiratory disease
Bronchus
Clinical form
Metabolic diseases
Autoimmune disease
Inflammation
Genetic disease
Case study
Respiratory tract
Pathology
Eye disease
Sjögren Larsson syndrome
Degenerative disease
ISSN:0954-6111, 1532-3064, 1532-3064
Online Access:Get full text
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Summary:The present study aimed to compare the cellular pattern and structural changes in the airways of patients with primary Sjögren's syndrome (pSS) with healthy controls. Bronchial biopsy specimens were obtained from seven subjects with pSS and seven healthy controls. All the patients with pSS had increased bronchial responsiveness to methacholine. In the biopsies inflammatory cells, cytokine-producing cells, tenascin and laminin were visualized by immunostaining. Patients with pSS had a higher number of neutrophils and mast cells than healthy controls, while the number of eosinophils was similar in the two groups. The number of IL-8-positive cells was higher in pSS but the numbers of IL-4-and IL-5-positive cells were not significantly different between pSS and healthy controls. The numbers of T cells in patients with pSS were higher than in healthy controls, while the numbers of CD25-positive cells were similar to the healthy controls. The degree of epithelial integrity in patients with pSS was significantly lower than in the control group and the tenascin and laminin layers were significantly thicker in the pSS group. There was a correlation between the number of mast cells and the thickness of the tenascin and laminin layers in pSS. In conclusion, we found that the cellular pattern in the bronchial mucosa of patients with pSS displayed large numbers of neutrophils, mast cells and T-lymphocytes. These changes in inflammatory cell numbers seemed to relate to the observed increased epithelial damage and structural changes of the subepithelium. The structural findings, but not the pattern of inflammatory cells, are shared with atopic asthma and may relate to the increased bronchial hyper-responsiveness seen in both diseases.
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ISSN:0954-6111
1532-3064
1532-3064
DOI:10.1053/rmed.2001.1174