Exercise and Neuroinflammation in Health and Disease

Neuroinflammation is a central pathological feature of several acute and chronic brain diseases, including Alzheimer disease (AD), Parkinson disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). It induces microglia activation, mitochondrial dysfunction, the production of n...

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Vydáno v:International neurourology journal Ročník 23; číslo Suppl 2; s. S82 - 92
Hlavní autoři: Seo, Dae-Yun, Heo, Jun-Won, Ko, Jeong Rim, Kwak, Hyo-Bum
Médium: Journal Article
Jazyk:angličtina
Vydáno: Korea (South) Korean Continence Society 01.11.2019
대한배뇨장애요실금학회
Témata:
disease
exercise
health
neuroinflammation
Review
비뇨기과학
Neuroinflammation
Exercise
Disease
Health
ISSN:2093-6931, 2093-4777, 2093-6931
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Shrnutí:Neuroinflammation is a central pathological feature of several acute and chronic brain diseases, including Alzheimer disease (AD), Parkinson disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). It induces microglia activation, mitochondrial dysfunction, the production of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), pro-inflammatory cytokines, and reactive oxygen species. Exercise, which plays an important role in maintaining and improving brain health, might be a highly effective intervention for preventing neuroinflammation-related diseases. Thus, since exercise can improve the neuroimmune response, we hypothesized that exercise would attenuate neuroinflammation-related diseases. In this review, we will highlight (1) the biological mechanisms that underlie AD, PD, ALS, and MS, including the neuroinflammation pathways associated with microglia activation, NF-κB, pro-inflammatory cytokines, mitochondrial dysfunction, and reactive oxygen species, and (2) the role of exercise in neuroinflammation-related neurodegenerative diseases.
Bibliografie:ObjectType-Article-1
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https://doi.org/10.5213/inj.1938214.107
ISSN:2093-6931
2093-4777
2093-6931
DOI:10.5213/inj.1938214.107