Bioactivity of dietary polyphenols: The role of metabolites

A polyphenol-rich diet protects against chronic pathologies by modulating numerous physiological processes, such as cellular redox potential, enzymatic activity, cell proliferation and signaling transduction pathways. However, polyphenols have a low oral bioavailability mainly due to an extensive bi...

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Vydané v:	Critical reviews in food science and nutrition Ročník 60; číslo 4; s. 626 - 659
Hlavní autori:	Luca, Simon Vlad, Macovei, Irina, Bujor, Alexandra, Miron, Anca, Skalicka-Woźniak, Krystyna, Aprotosoaie, Ana Clara, Trifan, Adriana
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Taylor & Francis 21.02.2020 Taylor & Francis Ltd
Predmet:	bioactive metabolites bioactive properties Bioavailability Biological activity Biological Availability Biological effects Biotransformation Cell proliferation Curcumin Daidzein Diet ellagitannins Enterocytes Enzymatic activity enzyme activity Gastrointestinal Microbiome - drug effects Genistein human health Humans Intestinal microflora intestinal microorganisms liver low oral bioavailability Metabolites Microbiota Microorganisms Pharmacokinetics Polyphenols Polyphenols - administration & dosage Polyphenols - metabolism Polyphenols - pharmacokinetics Polyphenols - pharmacology Proanthocyanidins Quercetin Redox potential Resveratrol Resveratrol - administration & dosage Resveratrol - metabolism Resveratrol - pharmacokinetics Resveratrol - pharmacology Rutin Signal transduction ellagitannins low oral bioavailability proanthocyanidins bioactive metabolites Resveratrol curcumin
ISSN:	1040-8398, 1549-7852, 1549-7852
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Shrnutí:	A polyphenol-rich diet protects against chronic pathologies by modulating numerous physiological processes, such as cellular redox potential, enzymatic activity, cell proliferation and signaling transduction pathways. However, polyphenols have a low oral bioavailability mainly due to an extensive biotransformation mediated by phase I and phase II reactions in enterocytes and liver but also by gut microbiota. Despite low oral bioavailability, most polyphenols proved significant biological effects which brought into attention the low bioavailability/high bioactivity paradox. In recent years, polyphenol metabolites have attracted great interest as many of them showed similar or higher intrinsic biological effects in comparison to the parent compounds. There is a huge body of literature reporting on the biological functions of polyphenol metabolites generated by phase I and phase II metabolic reactions and gut microbiota-mediated biotransformation. In this respect, the review highlights the pharmacokinetic fate of the major dietary polyphenols (resveratrol, curcumin, quercetin, rutin, genistein, daidzein, ellagitannins, proanthocyanidins) in order to further address the efficacy of biometabolites as compared to parent molecules. The present work strongly supports the contribution of metabolites to the health benefits of polyphenols, thus offering a better perspective in understanding the role played by dietary polyphenols in human health.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1040-8398 1549-7852 1549-7852
DOI:	10.1080/10408398.2018.1546669