Bioactivity of dietary polyphenols: The role of metabolites

A polyphenol-rich diet protects against chronic pathologies by modulating numerous physiological processes, such as cellular redox potential, enzymatic activity, cell proliferation and signaling transduction pathways. However, polyphenols have a low oral bioavailability mainly due to an extensive bi...

Full description

Saved in:
Bibliographic Details
Published in:Critical reviews in food science and nutrition Vol. 60; no. 4; pp. 626 - 659
Main Authors: Luca, Simon Vlad, Macovei, Irina, Bujor, Alexandra, Miron, Anca, Skalicka-Woźniak, Krystyna, Aprotosoaie, Ana Clara, Trifan, Adriana
Format: Journal Article
Language:English
Published: United States Taylor & Francis 21.02.2020
Taylor & Francis Ltd
Subjects:
bioactive metabolites
bioactive properties
Bioavailability
Biological activity
Biological Availability
Biological effects
Biotransformation
Cell proliferation
Curcumin
Daidzein
Diet
ellagitannins
Enterocytes
Enzymatic activity
enzyme activity
Gastrointestinal Microbiome - drug effects
Genistein
human health
Humans
Intestinal microflora
intestinal microorganisms
liver
low oral bioavailability
Metabolites
Microbiota
Microorganisms
Pharmacokinetics
Polyphenols
Polyphenols - administration & dosage
Polyphenols - metabolism
Polyphenols - pharmacokinetics
Polyphenols - pharmacology
Proanthocyanidins
Quercetin
Redox potential
Resveratrol
Resveratrol - administration & dosage
Resveratrol - metabolism
Resveratrol - pharmacokinetics
Resveratrol - pharmacology
Rutin
Signal transduction
ellagitannins
low oral bioavailability
proanthocyanidins
bioactive metabolites
Resveratrol
curcumin
ISSN:1040-8398, 1549-7852, 1549-7852
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A polyphenol-rich diet protects against chronic pathologies by modulating numerous physiological processes, such as cellular redox potential, enzymatic activity, cell proliferation and signaling transduction pathways. However, polyphenols have a low oral bioavailability mainly due to an extensive biotransformation mediated by phase I and phase II reactions in enterocytes and liver but also by gut microbiota. Despite low oral bioavailability, most polyphenols proved significant biological effects which brought into attention the low bioavailability/high bioactivity paradox. In recent years, polyphenol metabolites have attracted great interest as many of them showed similar or higher intrinsic biological effects in comparison to the parent compounds. There is a huge body of literature reporting on the biological functions of polyphenol metabolites generated by phase I and phase II metabolic reactions and gut microbiota-mediated biotransformation. In this respect, the review highlights the pharmacokinetic fate of the major dietary polyphenols (resveratrol, curcumin, quercetin, rutin, genistein, daidzein, ellagitannins, proanthocyanidins) in order to further address the efficacy of biometabolites as compared to parent molecules. The present work strongly supports the contribution of metabolites to the health benefits of polyphenols, thus offering a better perspective in understanding the role played by dietary polyphenols in human health.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:1040-8398
1549-7852
1549-7852
DOI:10.1080/10408398.2018.1546669