Phosphatidylinositolphosphate phosphatase activities and cancer

Signaling through the phosphoinositide 3-kinase pathways mediates the actions of a plethora of hormones, growth factors, cytokines, and neurotransmitters upon their target cells following receptor occupation. Overactivation of these pathways has been implicated in a number of pathologies, in particu...

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Veröffentlicht in:Journal of lipid research Jg. 57; H. 2; S. 176 - 192
Hauptverfasser: Rudge, Simon A, Wakelam, Michael J O
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Elsevier 01.02.2016
Schlagworte:
cancer
Gene Expression Regulation, Neoplastic
Humans
lipid kinases
Lipid Metabolism - genetics
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
phosphatases/lipid
Phosphatidylinositol 3-Kinases - genetics
Phosphatidylinositol 3-Kinases - metabolism
Phosphatidylinositol Phosphates - metabolism
Phosphatidylinositols - metabolism
phosphoinositide 3-kinase
phosphoinositides
Phosphoric Monoester Hydrolases - genetics
Phosphoric Monoester Hydrolases - metabolism
Signal Transduction
phosphatases/lipid
cancer
lipid kinases
phosphoinositide 3-kinase
phosphoinositides
ISSN:0022-2275, 1539-7262
Online-Zugang:Volltext
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Zusammenfassung:Signaling through the phosphoinositide 3-kinase pathways mediates the actions of a plethora of hormones, growth factors, cytokines, and neurotransmitters upon their target cells following receptor occupation. Overactivation of these pathways has been implicated in a number of pathologies, in particular a range of malignancies. The tight regulation of signaling pathways necessitates the involvement of both stimulatory and terminating enzymes; inappropriate activation of a pathway can thus result from activation or inhibition of the two signaling arms. The focus of this review is to discuss, in detail, the activities of the identified families of phosphoinositide phosphatase expressed in humans, and how they regulate the levels of phosphoinositides implicated in promoting malignancy.
Bibliographie:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0022-2275
1539-7262
DOI:10.1194/jlr.R059154