Redox-Sensitive and Hyaluronic Acid-Functionalized Nanoparticles for Improving Breast Cancer Treatment by Cytoplasmic 17α-Methyltestosterone Delivery

Novel reduction-responsive hyaluronic acid–chitosan–lipoic acid nanoparticles (HACSLA-NPs) were designed and synthesized for effective treatment of breast cancer by targeting Cluster of Differentiation 44 (CD44)-overexpressing cells and reduction-triggered 17α-Methyltestosterone (MT) release for sys...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 25; no. 5; p. 1181
Main Authors:	Rezaei, Somayeh, Kashanian, Soheila, Bahrami, Yadollah, Cruz, Luis J., Motiei, Marjan
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 05.03.2020 MDPI
Subjects:	17α-methyltestosterone Acids Androgens Antineoplastic Agents, Hormonal - administration & dosage Antineoplastic Agents, Hormonal - chemistry Apoptosis Biomarkers Breast cancer Cancer therapies cd44 Cell Line, Tumor Chemical bonds chitosan Drug Carriers - chemistry Drug Delivery Systems Drugs Female Fourier transforms Humans hyaluronic acid Hyaluronic Acid - chemistry Hydrogen-Ion Concentration Investigations lipoic acid Magnetic Resonance Spectroscopy Methyltestosterone - administration & dosage Methyltestosterone - chemistry Morphology Nanoparticles Nanoparticles - chemistry NMR Nuclear magnetic resonance Oxidation-Reduction - drug effects reduction-responsive nanoparticles Spectroscopy, Fourier Transform Infrared Spectrum analysis X-Ray Diffraction chitosan lipoic acid reduction-responsive nanoparticles 17α-methyltestosterone CD44 hyaluronic acid
ISSN:	1420-3049, 1420-3049
Online Access:	Get full text
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