Topical bioavailability of diclofenac from locally-acting, dermatological formulations

[Display omitted] Assessment of the bioavailability of topically applied drugs designed to act within or beneath the skin is a challenging objective. A number of different, but potentially complementary, techniques are under evaluation. The objective of this work was to evaluate in vitro skin penetr...

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Bibliographic Details
Published in:	International journal of pharmaceutics Vol. 529; no. 1-2; pp. 55 - 64
Main Authors:	Cordery, S.F., Pensado, A., Chiu, W.S., Shehab, M.Z., Bunge, A.L., Delgado-Charro, M.B., Guy, R.H.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 30.08.2017
Subjects:	Administration, Cutaneous Biological Availability Dermato-pharmacokinetics Diclofenac Diclofenac - administration & dosage Drug Delivery Systems Humans Skin Skin Absorption Topical bioavailability Topical bioequivalence Q1 A Q2 FDA DMSO MR,jh Topical bioavailability MS,n Diclofenac MUp,6h P SC IVPT S Δ ANOVA V Topical bioequivalence VS,n Dermato-pharmacokinetics HPLC QR TEWL Jinvivo Jinvitro MR MCl,23h tn Skin VR
ISSN:	0378-5173, 1873-3476, 1873-3476
Online Access:	Get full text
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