The Brilliance of the Zebrafish Model: Perception on Behavior and Alzheimer’s Disease

Alzheimer’s disease (AD) has become increasingly prevalent in the elderly population across the world. It’s pathophysiological markers such as overproduction along with the accumulation of amyloid beta (Aβ) plaques and neurofibrillary tangles (NFT) are posing a serious challenge to novel drug develo...

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Published in:Frontiers in behavioral neuroscience Vol. 16; p. 861155
Main Authors: Shenoy, Avinash, Banerjee, Meheli, Upadhya, Archana, Bagwe-Parab, Siddhi, Kaur, Ginpreet
Format: Journal Article
Language:English
Published: Switzerland Frontiers Research Foundation 13.06.2022
Frontiers Media S.A
Subjects:
Aging
Alzheimer's disease
behavior
Behavioral Neuroscience
Biomarkers
Brain research
cholinergic
Clinical trials
Cognitive ability
Danio rerio
Dopamine
Drug development
Drug screening
Embryos
Genetic engineering
Geriatrics
glutamatergic
Glutamatergic transmission
Mammals
Memory
Neurodegeneration
Neurodegenerative diseases
Neurofibrillary tangles
Neuroimaging
Proteins
Senile plaques
Spatial memory
Therapeutic applications
Zebrafish
γ-Aminobutyric acid
zebrafish
Alzheimer’s disease
behavior
glutamatergic
cholinergic
ISSN:1662-5153, 1662-5153
Online Access:Get full text
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Summary:Alzheimer’s disease (AD) has become increasingly prevalent in the elderly population across the world. It’s pathophysiological markers such as overproduction along with the accumulation of amyloid beta (Aβ) plaques and neurofibrillary tangles (NFT) are posing a serious challenge to novel drug development processes. A model which simulates the human neurodegenerative mechanism will be beneficial for rapid screening of potential drug candidates. Due to the comparable neurological network with humans, zebrafish has emerged as a promising AD model. This model has been thoroughly validated through research in aspects of neuronal pathways analogous to the human brain. The cholinergic, glutamatergic, and GABAergic pathways, which play a role in the manifested behavior of the zebrafish, are well defined. There are several behavioral models in both adult zebrafish and larvae to establish various aspects of cognitive impairment including spatial memory, associative memory, anxiety, and other such features that are manifested in AD. The zebrafish model eliminates the shortcomings of previously recognized mammalian models, in terms of expense, extensive assessment durations, and the complexity of imaging the brain to test the efficacy of therapeutic interventions. This review highlights the various models that analyze the changes in the normal behavioral patterns of the zebrafish when exposed to AD inducing agents. The mechanistic pathway adopted by drugs and novel therapeutic strategies can be explored via these behavioral models and their efficacy to slow the progression of AD can be evaluated.
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Reviewed by: Robert Knepp, North Greenville University, United States; Ayodeji O. Ipinmoroti, Alabama State University, United States
Edited by: Adebobola Imeh-Nathaniel, North Greenville University, United States
This article was submitted to Learning and Memory, a section of the journal Frontiers in Behavioral Neuroscience
ISSN:1662-5153
1662-5153
DOI:10.3389/fnbeh.2022.861155