Functional magnetic resonance imaging exploration of combined hand and speech movements in Parkinson's disease
Among the repertoire of motor functions, although hand movement and speech production tasks have been investigated widely by functional neuroimaging, paradigms combining both movements have been studied less so. Such paradigms are of particular interest in Parkinson's disease, in which patients...
Saved in:
| Published in: | Movement disorders Vol. 26; no. 12; pp. 2212 - 2219 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.10.2011
Wiley |
| Subjects: | |
| ISSN: | 0885-3185, 1531-8257, 1531-8257 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Among the repertoire of motor functions, although hand movement and speech production tasks have been investigated widely by functional neuroimaging, paradigms combining both movements have been studied less so. Such paradigms are of particular interest in Parkinson's disease, in which patients have specific difficulties performing two movements simultaneously. In 9 unmedicated patients with Parkinson's disease and 15 healthy control subjects, externally cued tasks (i.e., hand movement, speech production, and combined hand movement and speech production) were performed twice in a random order and functional magnetic resonance imaging detected cerebral activations, compared to the rest. F‐statistics tested within‐group (significant activations at P values < 0.05, familywise error corrected), between‐group, and between‐task comparisons (regional activations significant at P values < 0.001, uncorrected, with cluster size > 10 voxels). For control subjects, the combined task activations comprised the sum of those obtained during hand movement and speech production performed separately, reflecting the neural correlates of performing movements sharing similar programming modalities. In patients with Parkinson's disease, only activations underlying hand movement were observed during the combined task. We interpreted this phenomenon as patients' potential inability to recruit facilitatory activations while performing two movements simultaneously. This lost capacity could be related to a functional prioritization of one movement (i.e., hand movement), in comparison with the other (i.e., speech production). Our observation could also reflect the inability of patients with Parkinson's disease to intrinsically engage the motor coordination necessary to perform a combined task. © 2011 Movement Disorder Society |
|---|---|
| AbstractList | Among the repertoire of motor functions, although hand movement and speech production tasks have been investigated widely by functional neuroimaging, paradigms combining both movements have been studied less so. Such paradigms are of particular interest in Parkinson's disease, in which patients have specific difficulties performing two movements simultaneously. In 9 unmedicated patients with Parkinson's disease and 15 healthy control subjects, externally cued tasks (i.e., hand movement, speech production, and combined hand movement and speech production) were performed twice in a random order and functional magnetic resonance imaging detected cerebral activations, compared to the rest. F‐statistics tested within‐group (significant activations at P values < 0.05, familywise error corrected), between‐group, and between‐task comparisons (regional activations significant at P values < 0.001, uncorrected, with cluster size > 10 voxels). For control subjects, the combined task activations comprised the sum of those obtained during hand movement and speech production performed separately, reflecting the neural correlates of performing movements sharing similar programming modalities. In patients with Parkinson's disease, only activations underlying hand movement were observed during the combined task. We interpreted this phenomenon as patients' potential inability to recruit facilitatory activations while performing two movements simultaneously. This lost capacity could be related to a functional prioritization of one movement (i.e., hand movement), in comparison with the other (i.e., speech production). Our observation could also reflect the inability of patients with Parkinson's disease to intrinsically engage the motor coordination necessary to perform a combined task. © 2011 Movement Disorder Society Among the repertoire of motor functions, although hand movement and speech production tasks have been investigated widely by functional neuroimaging, paradigms combining both movements have been studied less so. Such paradigms are of particular interest in Parkinson's disease, in which patients have specific difficulties performing two movements simultaneously. In 9 unmedicated patients with Parkinson's disease and 15 healthy control subjects, externally cued tasks (i.e., hand movement, speech production, and combined hand movement and speech production) were performed twice in a random order and functional magnetic resonance imaging detected cerebral activations, compared to the rest. F-statistics tested within-group (significant activations at P values < 0.05, familywise error corrected), between-group, and between-task comparisons (regional activations significant at P values < 0.001, uncorrected, with cluster size > 10 voxels). For control subjects, the combined task activations comprised the sum of those obtained during hand movement and speech production performed separately, reflecting the neural correlates of performing movements sharing similar programming modalities. In patients with Parkinson's disease, only activations underlying hand movement were observed during the combined task. We interpreted this phenomenon as patients' potential inability to recruit facilitatory activations while performing two movements simultaneously. This lost capacity could be related to a functional prioritization of one movement (i.e., hand movement), in comparison with the other (i.e., speech production). Our observation could also reflect the inability of patients with Parkinson's disease to intrinsically engage the motor coordination necessary to perform a combined task.Among the repertoire of motor functions, although hand movement and speech production tasks have been investigated widely by functional neuroimaging, paradigms combining both movements have been studied less so. Such paradigms are of particular interest in Parkinson's disease, in which patients have specific difficulties performing two movements simultaneously. In 9 unmedicated patients with Parkinson's disease and 15 healthy control subjects, externally cued tasks (i.e., hand movement, speech production, and combined hand movement and speech production) were performed twice in a random order and functional magnetic resonance imaging detected cerebral activations, compared to the rest. F-statistics tested within-group (significant activations at P values < 0.05, familywise error corrected), between-group, and between-task comparisons (regional activations significant at P values < 0.001, uncorrected, with cluster size > 10 voxels). For control subjects, the combined task activations comprised the sum of those obtained during hand movement and speech production performed separately, reflecting the neural correlates of performing movements sharing similar programming modalities. In patients with Parkinson's disease, only activations underlying hand movement were observed during the combined task. We interpreted this phenomenon as patients' potential inability to recruit facilitatory activations while performing two movements simultaneously. This lost capacity could be related to a functional prioritization of one movement (i.e., hand movement), in comparison with the other (i.e., speech production). Our observation could also reflect the inability of patients with Parkinson's disease to intrinsically engage the motor coordination necessary to perform a combined task. Among the repertoire of motor functions, although hand movement and speech production tasks have been investigated widely by functional neuroimaging, paradigms combining both movements have been studied less so. Such paradigms are of particular interest in Parkinson's disease, in which patients have specific difficulties performing two movements simultaneously. In 9 unmedicated patients with Parkinson's disease and 15 healthy control subjects, externally cued tasks (i.e., hand movement, speech production, and combined hand movement and speech production) were performed twice in a random order and functional magnetic resonance imaging detected cerebral activations, compared to the rest. F-statistics tested within-group (significant activations at P values < 0.05, familywise error corrected), between-group, and between-task comparisons (regional activations significant at P values < 0.001, uncorrected, with cluster size > 10 voxels). For control subjects, the combined task activations comprised the sum of those obtained during hand movement and speech production performed separately, reflecting the neural correlates of performing movements sharing similar programming modalities. In patients with Parkinson's disease, only activations underlying hand movement were observed during the combined task. We interpreted this phenomenon as patients' potential inability to recruit facilitatory activations while performing two movements simultaneously. This lost capacity could be related to a functional prioritization of one movement (i.e., hand movement), in comparison with the other (i.e., speech production). Our observation could also reflect the inability of patients with Parkinson's disease to intrinsically engage the motor coordination necessary to perform a combined task. |
| Author | Jahanshahi, Marjan Limousin, Patricia Thornton, John S. Pinto, Serge Yousry, Tarek A. Mancini, Laura Tripoliti, Elina |
| Author_xml | – sequence: 1 givenname: Serge surname: Pinto fullname: Pinto, Serge email: serge.pinto@lpl-aix.fr organization: Laboratoire Parole et Langage, Aix-en-Provence, France – sequence: 2 givenname: Laura surname: Mancini fullname: Mancini, Laura organization: Queen Square Imaging Center, London, United Kingdom – sequence: 3 givenname: Marjan surname: Jahanshahi fullname: Jahanshahi, Marjan organization: Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom – sequence: 4 givenname: John S. surname: Thornton fullname: Thornton, John S. organization: Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, UCLH NHS Trust, London, United Kingdom – sequence: 5 givenname: Elina surname: Tripoliti fullname: Tripoliti, Elina organization: Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom – sequence: 6 givenname: Tarek A. surname: Yousry fullname: Yousry, Tarek A. organization: Queen Square Imaging Center, London, United Kingdom – sequence: 7 givenname: Patricia surname: Limousin fullname: Limousin, Patricia organization: Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24704436$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/21714000$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kU9v1DAQxS3Uim4LB74A8gVVHNKOY8d2jqiw_aO2IAGCm-U4k9aQOFs7C-23x9vdFgmJHkYjjX7vSfPeLtkKY0BCXjE4YADl4dCmg5Krun5GZqzirNBlpbbIDLSuCs50tUN2U_oBwFjF5HOyUzLFBADMSJgvg5v8GGxPB3sVcPKORkz5EBxSn28-XFG8XfRjtCuQjh1149D4gC29tqGlq0kLRHdNh_EXDhimRH2gn2z86UO22k-09Qltwhdku7N9wpebvUe-zj98OTopzj8enx69Oy-cqHldcIDaMdSixLYCQMld07TQQIdaN6xEZJ1qtZaVRN6VWjagWNPKWiiHiiu-R_bXvos43iwxTWbwyWHf24DjMpkaQHLNVZXJ1xty2QzYmkXMP8c78xBRBt5sAJuc7buYg_HpLycUCMFl5t6uORfHlCJ2jwgDs6rJ5JrMfU2ZPfyHdX66T3eK1vdPKX77Hu_-b20u3n9-UBRrhU8T3j4qcidG5ogq8-3y2JxpNT8Rojbf-R-wj7MH |
| CitedBy_id | crossref_primary_10_3389_fnhum_2023_1250114 crossref_primary_10_1016_j_parkreldis_2021_04_025 crossref_primary_10_3389_fneur_2020_00127 crossref_primary_10_2217_nmt_15_16 crossref_primary_10_1038_s41531_022_00286_y crossref_primary_10_1212_WNL_0000000000012878 crossref_primary_10_3389_fnhum_2024_1383714 crossref_primary_10_1038_s41531_023_00495_z crossref_primary_10_1371_journal_pone_0049056 crossref_primary_10_1038_s41531_019_0092_6 crossref_primary_10_1002_hbm_22397 crossref_primary_10_1016_j_neures_2014_10_004 crossref_primary_10_1111_cns_13304 crossref_primary_10_1038_s41598_021_01386_0 crossref_primary_10_1002_hbm_22748 crossref_primary_10_1016_j_nicl_2023_103399 crossref_primary_10_1016_j_jcomdis_2021_106149 crossref_primary_10_1016_j_nicl_2020_102285 crossref_primary_10_1371_journal_pone_0056133 crossref_primary_10_1007_s11682_016_9588_4 crossref_primary_10_1002_mds_27791 crossref_primary_10_1016_j_wocn_2017_01_009 crossref_primary_10_3917_rfla_172_0019 crossref_primary_10_1002_mds_28468 crossref_primary_10_1016_j_bspc_2014_04_009 |
| Cites_doi | 10.1016/j.neuroimage.2006.11.047 10.1016/S1471-1931(00)00028-8 10.1002/mds.20958 10.1093/brain/awh569 10.1016/0306-4522(94)90536-3 10.1093/brain/123.2.394 10.1159/000314357 10.1136/jnnp.2007.126599 10.1016/0166-2236(90)90107-L 10.1093/brain/118.4.913 10.1093/brain/awh074 10.1093/brain/awl162 10.1002/hbm.20859 10.1037/0033-2909.116.2.220 10.1136/jnnp.51.6.745 10.1111/j.1600-0404.2007.00818.x 10.1016/j.tins.2008.02.011 10.1002/mds.21548 10.1016/S0093-934X(02)00002-0 10.1093/brain/awf036 10.1111/j.1468-1331.2009.02612.x 10.1002/mds.22296 10.1523/JNEUROSCI.5441-06.2007 10.1016/j.neuroimage.2005.12.024 10.1002/mds.22219 10.1044/1058-0360(2008/08-0004) 10.1212/WNL.60.3.432 10.1002/1531-8249(200008)48:2<268::AID-ANA21>3.0.CO;2-4 10.1016/j.jns.2008.06.024 10.1002/hbm.460020402 10.1016/S1053-8119(03)00059-4 |
| ContentType | Journal Article |
| Copyright | Copyright © 2011 Movement Disorder Society 2015 INIST-CNRS Copyright © 2011 Movement Disorder Society. |
| Copyright_xml | – notice: Copyright © 2011 Movement Disorder Society – notice: 2015 INIST-CNRS – notice: Copyright © 2011 Movement Disorder Society. |
| DBID | BSCLL AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1002/mds.23799 |
| DatabaseName | Istex CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | CrossRef MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1531-8257 |
| EndPage | 2219 |
| ExternalDocumentID | 21714000 24704436 10_1002_mds_23799 MDS23799 ark_67375_WNG_J87FH449_X |
| Genre | article Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NINDS NIH HHS grantid: R01-NS40856-02 – fundername: Department of Health – fundername: Wellcome Trust – fundername: NINDS NIH HHS grantid: R01-NS40902 – fundername: NINDS NIH HHS grantid: R01 NS040865 – fundername: NINDS NIH HHS grantid: R01 NS040902 |
| GroupedDBID | --- .3N .GA .GJ .Y3 05W 0R~ 10A 123 1CY 1L6 1OB 1OC 1ZS 31~ 33P 3PY 3SF 3WU 4.4 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5VS 66C 6PF 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHQN AAIPD AAMMB AAMNL AANHP AANLZ AAONW AASGY AAWTL AAXRX AAYCA AAZKR ABCQN ABCUV ABEML ABIJN ABJNI ABLJU ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCZN ACGFS ACGOF ACMXC ACPOU ACPRK ACRPL ACSCC ACXBN ACXQS ACYXJ ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADNMO ADOZA ADXAS ADZMN AEFGJ AEIGN AEIMD AENEX AEUYR AEYWJ AFBPY AFFPM AFGKR AFWVQ AFZJQ AGHNM AGQPQ AGXDD AGYGG AHBTC AHMBA AIACR AIDQK AIDYY AIQQE AITYG AIURR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BSCLL BY8 C45 CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR1 DR2 DRFUL DRMAN DRSTM DU5 EBD EBS EJD EMOBN F00 F01 F04 F5P FEDTE FUBAC FYBCS G-S G.N GNP GODZA H.X HBH HF~ HGLYW HHY HHZ HVGLF HZ~ IX1 J0M JPC KBYEO KQQ LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M6M MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ NNB O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 QRW R.K RIWAO RJQFR ROL RX1 RYL SAMSI SUPJJ SV3 TEORI TWZ UB1 V2E V9Y W8V W99 WBKPD WHWMO WIB WIH WIJ WIK WJL WOHZO WQJ WVDHM WXI WXSBR XG1 XV2 ZGI ZZTAW ~IA ~WT AAYXX CITATION O8X IQODW CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c4939-3009c1e842ed500e63cbbd0b0fe88b12ee1f7d88656e3f286b071bd6947ce7373 |
| IEDL.DBID | DRFUL |
| ISICitedReferencesCount | 34 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000296610900015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0885-3185 1531-8257 |
| IngestDate | Fri Jul 11 08:09:49 EDT 2025 Mon Jul 21 05:50:49 EDT 2025 Mon Jul 21 09:12:10 EDT 2025 Tue Nov 18 21:01:51 EST 2025 Sat Nov 29 07:04:53 EST 2025 Sun Sep 21 06:19:21 EDT 2025 Sun Sep 21 06:19:07 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 12 |
| Keywords | Nervous system diseases Parkinson's disease Parkinson disease Exploration dual task speech production Nuclear magnetic resonance imaging Hand Cerebral disorder Central nervous system disease Speech Degenerative disease functional magnetic resonance imaging Extrapyramidal syndrome Functional imaging hand movement |
| Language | English |
| License | http://onlinelibrary.wiley.com/termsAndConditions#vor CC BY 4.0 Copyright © 2011 Movement Disorder Society. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4939-3009c1e842ed500e63cbbd0b0fe88b12ee1f7d88656e3f286b071bd6947ce7373 |
| Notes | Full financial disclosures and author roles may be found in the online version of this article. Relevant conflicts of interest/financial disclosures: Nothing to report. ArticleID:MDS23799 ark:/67375/WNG-J87FH449-X Funding agencies: Fondation Simone et Cino Del Duca, The Wellcome Trust, Medtronic, National Institutes of Health (Bethesda, MD) contracts RO1-NS40902 (PI: Daniel Corcos) and RO1-NS40856-02 (PI: M.J.), the Parkinson's Disease Society UK, and the Parkinson's Appeal. This work was undertaken at UCLH/UCL, which received a proportion of funding from the Department of Health's NIHR Biomedical Research Centers funding scheme. istex:7E42461455C59B1B37A4EF0EECE281E61FA5FABB Nothing to report. Relevant conflicts of interest/financial disclosures Funding agencies Fondation Simone et Cino Del Duca, The Wellcome Trust, Medtronic, National Institutes of Health (Bethesda, MD) contracts RO1‐NS40902 (PI: Daniel Corcos) and RO1‐NS40856‐02 (PI: M.J.), the Parkinson's Disease Society UK, and the Parkinson's Appeal. This work was undertaken at UCLH/UCL, which received a proportion of funding from the Department of Health's NIHR Biomedical Research Centers funding scheme. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/3184369 |
| PMID | 21714000 |
| PQID | 900638375 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_900638375 pubmed_primary_21714000 pascalfrancis_primary_24704436 crossref_primary_10_1002_mds_23799 crossref_citationtrail_10_1002_mds_23799 wiley_primary_10_1002_mds_23799_MDS23799 istex_primary_ark_67375_WNG_J87FH449_X |
| PublicationCentury | 2000 |
| PublicationDate | October 2011 |
| PublicationDateYYYYMMDD | 2011-10-01 |
| PublicationDate_xml | – month: 10 year: 2011 text: October 2011 |
| PublicationDecade | 2010 |
| PublicationPlace | Hoboken |
| PublicationPlace_xml | – name: Hoboken – name: Hoboken, NJ – name: United States |
| PublicationTitle | Movement disorders |
| PublicationTitleAlternate | Mov. Disord |
| PublicationYear | 2011 |
| Publisher | Wiley Subscription Services, Inc., A Wiley Company Wiley |
| Publisher_xml | – name: Wiley Subscription Services, Inc., A Wiley Company – name: Wiley |
| References | Jahanshahi M, Jenkins HI, Brown RG, Marsden CD, Pasingham RE, Brooks D. Self-initiated versus externally triggered movements. I. An investigation using measurement of regional cerebral blood flow with PET and movement-related potentials in normal and Parkinson's disease subjects. Brain 1995; 118: 913-933. Gibb WR, Lees AJ. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry 1988; 51: 745-752. World Medical Association General Assembly. Declaration of Helsinki, Amendment. Tokyo: 2004. Talairach J, Tournoux P. Co-planar Stereotaxic Atlas of the Human Brain. New York: Thième Medical; 1988. Wu T, Hallett M. Neural correlates of dual task performance in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry 2008; 79: 760-766. Pashler H. Dual-task interference in simple tasks: data and theory. Psychol Bull 1994; 116: 101-132. Graber S, Hertrich I, Daum I, Spieker S, Ackermann H. Speech perception deficits in Parkinson's disease: underestimation of time intervals compromises identification of durational phonetic contrasts. Brain Lang 2002; 82: 65-74. Rochester L, Nieuwboer A, Baker K, et al. Walking speed during single and dual tasks in Parkinson's disease: which characteristics are important? Mov Disord 2008; 23: 2312-2318. Wu T, Hallett M. A functional MRI study of automatic movements in patients with Parkinson's disease. Brain 2005; 28: 2250-2259. Yu H, Sternad D, Corcos DM, Vaillancourt DE. Role of hyperactive cerebellum and motor cortex in Parkinson's disease. Neuroimage 2007; 35: 222-233. Bloem BR, Grimbergen YA, Cramer M, Valkenburg VV. "Stops walking when talking" does not predict falls in Parkinson's disease. Ann Neurol 2000; 48: 268. Sachin S, Senthil Kumaran S, Singh S, Goyal V, Shukla G, Mahajan H, Behari M. Functional mapping in PD and PSP for sustained phonation and phoneme tasks. J Neurol Sci 2008; 273: 51-56. Rektorova I, Barrett J, Mikl M, Rektor I, Paus T. Functional abnormalities in the primary orofacial sensorimotor cortex during speech in Parkinson's disease. Mov Disord 2007; 22: 2043-2051. Asanuma K, Tang C, Ma Y, et al. Network modulation in the treatment of Parkinson's disease. Brain 2006; 129: 2667-2678. Trost M, Su S, Su P, et al. Network modulation by the subthalamic nucleus in the treatment of Parkinson's disease. Neuroimage 2006; 31: 301-307. Aström M, Tripoliti E, Hariz MI, Zrinzo LU, Martinez-Torres I, Limousin P, Wårdell K. Patient-specific model-based investigation of speech intelligibility and movement during deep brain stimulation. Stereotact Funct Neurosurg 2010; 88: 224-233. Turner RS, Grafton ST, McIntosh AR, DeLong MR, Hoffman JM. The functional anatomy of parkinsonian bradykinesia. Neuroimage 2003; 19: 163-179. Rowe J, Stephan KE, Friston K, Frackowiak R, Lees A, Passingham R. Attention to action in Parkinson's disease. Impaired effective connectivity among frontal cortical regions. Brain 2002; 125: 276-289. Ackermann H. Cerebellar contributions to speech production and speech perception: psycholinguistic and neurobiological perspectives. Trends Neurosci 2008; 31: 265-272. Narayana S, Fox PT, Zhang W, Franklin C, Robin DA, Vogel D, Ramig LO. Neural correlates of efficacy of voice therapy in Parkinson's disease identified by performance-correlation analysis. Hum Brain Map 2010; 31: 222-236. Purzner J, Paradiso GO, Cunic D, et al. Involvement of the basal ganglia and cerebellar motor pathways in the preparation of self-initiated and externally triggered movements in humans. J Neurosci 2007; 27: 6029-6036. Sabatini U, Boulanouar K, Fabre N, et al. Cortical motor reorganization in akinetic patients with Parkinson's disease: a functional MRI study. Brain 2000; 23: 394-403. Pinto S, Thobois S, Costes N, et al. Subthalamic nucleus stimulation and dysarthria in Parkinson's disease: a PET study. Brain 2004; 127: 602-615. Alexander GE, Crutcher MD. Functional architecture of basal ganglia circuits: neural substrates of parallel processing. Trends Neurosci 1990; 13: 266-271. Tripoliti E, Zrinzo L, Martinez-Torres I, et al. Effects of contact location and voltage amplitude on speech and movement in bilateral subthalamic nucleus deep brain stimulation. Mov Disord 2008; 23: 2377-2383. Obeso JA, Rodriguez-Oroz MC, Rodriguez M, Lanciego JL, Artieda J, Gonzalo N, Olanow CW. Pathophysiology of the basal ganglia in Parkinson's disease. Trends Neurosci 2000; 23: S8-S19. Joel D, Weiner I. The organization of the basal ganglia-thalamocortical circuits: open interconnected rather than closed segregated. Neuroscience 1994; 63: 363-379. Narayana S, Jacks A, Robin DA, et al. A noninvasive imaging approach to understanding speech changes following deep brain stimulation in Parkinson's disease. Am J Speech Lang Pathol 2009; 18: 146-161. Kopell BH, Rezai AR, Chang JW, Vitek JL. Anatomy and physiology of the basal ganglia: implications for deep brain stimulation for Parkinson's disease. Mov Disord 2006; 21: S238-S246. Liotti M, Ramig LO, Vogel D, et al. Hypophonia in Parkinson's disease: neural correlates of voice treatment revealed by PET. Neurology 2003; 60: 432-440. Friston K, Holmes A, Worsley K, Poline J, Frith C, Frackowiak R. Statistical parametric maps in functional imaging: a general linear approach. Hum Brain Map 1995; 2: 189-210. Beauchet O, Annweiler C, Dubost V, et al. Stops walking when talking: a predictor of falls in older adults? Eur J Neurol 2009; 16: 786-795. 2010; 31 2004; 127 1994; 116 2006; 31 1990; 13 2000; 48 2000; 23 1995; 118 2008; 79 1988; 51 2004 2002; 82 2003; 19 2008; 31 1995; 2 2005; 28 2007; 35 1994; 63 2010; 88 2006; 21 2002; 125 1987 2008; 23 2003; 60 2007; 22 2006; 129 2008; 273 2009; 16 2009; 18 1988 2007; 27 e_1_2_8_27_2 e_1_2_8_28_2 e_1_2_8_29_2 e_1_2_8_23_2 (e_1_2_8_16_2) 2004 e_1_2_8_24_2 e_1_2_8_25_2 e_1_2_8_26_2 e_1_2_8_9_2 Pashler H (e_1_2_8_34_2) 1994; 116 Talairach J (e_1_2_8_18_2) 1988 e_1_2_8_2_2 e_1_2_8_4_2 e_1_2_8_3_2 e_1_2_8_6_2 e_1_2_8_5_2 e_1_2_8_8_2 e_1_2_8_7_2 e_1_2_8_20_2 e_1_2_8_21_2 e_1_2_8_22_2 e_1_2_8_17_2 e_1_2_8_19_2 e_1_2_8_12_2 e_1_2_8_13_2 e_1_2_8_14_2 e_1_2_8_15_2 e_1_2_8_31_2 e_1_2_8_30_2 e_1_2_8_10_2 e_1_2_8_33_2 e_1_2_8_11_2 e_1_2_8_32_2 |
| References_xml | – reference: Kopell BH, Rezai AR, Chang JW, Vitek JL. Anatomy and physiology of the basal ganglia: implications for deep brain stimulation for Parkinson's disease. Mov Disord 2006; 21: S238-S246. – reference: Alexander GE, Crutcher MD. Functional architecture of basal ganglia circuits: neural substrates of parallel processing. Trends Neurosci 1990; 13: 266-271. – reference: Sabatini U, Boulanouar K, Fabre N, et al. Cortical motor reorganization in akinetic patients with Parkinson's disease: a functional MRI study. Brain 2000; 23: 394-403. – reference: Asanuma K, Tang C, Ma Y, et al. Network modulation in the treatment of Parkinson's disease. Brain 2006; 129: 2667-2678. – reference: Rektorova I, Barrett J, Mikl M, Rektor I, Paus T. Functional abnormalities in the primary orofacial sensorimotor cortex during speech in Parkinson's disease. Mov Disord 2007; 22: 2043-2051. – reference: Sachin S, Senthil Kumaran S, Singh S, Goyal V, Shukla G, Mahajan H, Behari M. Functional mapping in PD and PSP for sustained phonation and phoneme tasks. J Neurol Sci 2008; 273: 51-56. – reference: Rochester L, Nieuwboer A, Baker K, et al. Walking speed during single and dual tasks in Parkinson's disease: which characteristics are important? Mov Disord 2008; 23: 2312-2318. – reference: Ackermann H. Cerebellar contributions to speech production and speech perception: psycholinguistic and neurobiological perspectives. Trends Neurosci 2008; 31: 265-272. – reference: Friston K, Holmes A, Worsley K, Poline J, Frith C, Frackowiak R. Statistical parametric maps in functional imaging: a general linear approach. Hum Brain Map 1995; 2: 189-210. – reference: Purzner J, Paradiso GO, Cunic D, et al. Involvement of the basal ganglia and cerebellar motor pathways in the preparation of self-initiated and externally triggered movements in humans. J Neurosci 2007; 27: 6029-6036. – reference: Liotti M, Ramig LO, Vogel D, et al. Hypophonia in Parkinson's disease: neural correlates of voice treatment revealed by PET. Neurology 2003; 60: 432-440. – reference: Pashler H. Dual-task interference in simple tasks: data and theory. Psychol Bull 1994; 116: 101-132. – reference: Turner RS, Grafton ST, McIntosh AR, DeLong MR, Hoffman JM. The functional anatomy of parkinsonian bradykinesia. Neuroimage 2003; 19: 163-179. – reference: Rowe J, Stephan KE, Friston K, Frackowiak R, Lees A, Passingham R. Attention to action in Parkinson's disease. Impaired effective connectivity among frontal cortical regions. Brain 2002; 125: 276-289. – reference: Beauchet O, Annweiler C, Dubost V, et al. Stops walking when talking: a predictor of falls in older adults? Eur J Neurol 2009; 16: 786-795. – reference: Yu H, Sternad D, Corcos DM, Vaillancourt DE. Role of hyperactive cerebellum and motor cortex in Parkinson's disease. Neuroimage 2007; 35: 222-233. – reference: Talairach J, Tournoux P. Co-planar Stereotaxic Atlas of the Human Brain. New York: Thième Medical; 1988. – reference: Obeso JA, Rodriguez-Oroz MC, Rodriguez M, Lanciego JL, Artieda J, Gonzalo N, Olanow CW. Pathophysiology of the basal ganglia in Parkinson's disease. Trends Neurosci 2000; 23: S8-S19. – reference: Narayana S, Jacks A, Robin DA, et al. A noninvasive imaging approach to understanding speech changes following deep brain stimulation in Parkinson's disease. Am J Speech Lang Pathol 2009; 18: 146-161. – reference: Aström M, Tripoliti E, Hariz MI, Zrinzo LU, Martinez-Torres I, Limousin P, Wårdell K. Patient-specific model-based investigation of speech intelligibility and movement during deep brain stimulation. Stereotact Funct Neurosurg 2010; 88: 224-233. – reference: Trost M, Su S, Su P, et al. Network modulation by the subthalamic nucleus in the treatment of Parkinson's disease. Neuroimage 2006; 31: 301-307. – reference: Jahanshahi M, Jenkins HI, Brown RG, Marsden CD, Pasingham RE, Brooks D. Self-initiated versus externally triggered movements. I. An investigation using measurement of regional cerebral blood flow with PET and movement-related potentials in normal and Parkinson's disease subjects. Brain 1995; 118: 913-933. – reference: Tripoliti E, Zrinzo L, Martinez-Torres I, et al. Effects of contact location and voltage amplitude on speech and movement in bilateral subthalamic nucleus deep brain stimulation. Mov Disord 2008; 23: 2377-2383. – reference: Bloem BR, Grimbergen YA, Cramer M, Valkenburg VV. "Stops walking when talking" does not predict falls in Parkinson's disease. Ann Neurol 2000; 48: 268. – reference: Pinto S, Thobois S, Costes N, et al. Subthalamic nucleus stimulation and dysarthria in Parkinson's disease: a PET study. Brain 2004; 127: 602-615. – reference: Gibb WR, Lees AJ. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry 1988; 51: 745-752. – reference: Wu T, Hallett M. A functional MRI study of automatic movements in patients with Parkinson's disease. Brain 2005; 28: 2250-2259. – reference: Joel D, Weiner I. The organization of the basal ganglia-thalamocortical circuits: open interconnected rather than closed segregated. Neuroscience 1994; 63: 363-379. – reference: Wu T, Hallett M. Neural correlates of dual task performance in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry 2008; 79: 760-766. – reference: Narayana S, Fox PT, Zhang W, Franklin C, Robin DA, Vogel D, Ramig LO. Neural correlates of efficacy of voice therapy in Parkinson's disease identified by performance-correlation analysis. Hum Brain Map 2010; 31: 222-236. – reference: World Medical Association General Assembly. Declaration of Helsinki, Amendment. Tokyo: 2004. – reference: Graber S, Hertrich I, Daum I, Spieker S, Ackermann H. Speech perception deficits in Parkinson's disease: underestimation of time intervals compromises identification of durational phonetic contrasts. Brain Lang 2002; 82: 65-74. – volume: 16 start-page: 786 year: 2009 end-page: 795 article-title: Stops walking when talking: a predictor of falls in older adults? publication-title: Eur J Neurol – volume: 13 start-page: 266 year: 1990 end-page: 271 article-title: Functional architecture of basal ganglia circuits: neural substrates of parallel processing publication-title: Trends Neurosci – volume: 27 start-page: 6029 year: 2007 end-page: 6036 article-title: Involvement of the basal ganglia and cerebellar motor pathways in the preparation of self‐initiated and externally triggered movements in humans publication-title: J Neurosci – volume: 273 start-page: 51 year: 2008 end-page: 56 article-title: Functional mapping in PD and PSP for sustained phonation and phoneme tasks publication-title: J Neurol Sci – volume: 23 start-page: 394 year: 2000 end-page: 403 article-title: Cortical motor reorganization in akinetic patients with Parkinson's disease: a functional MRI study publication-title: Brain – volume: 48 start-page: 268 year: 2000 article-title: “Stops walking when talking” does not predict falls in Parkinson's disease publication-title: Ann Neurol – volume: 118 start-page: 913 year: 1995 end-page: 933 article-title: Self‐initiated versus externally triggered movements. I. An investigation using measurement of regional cerebral blood flow with PET and movement‐related potentials in normal and Parkinson's disease subjects publication-title: Brain – volume: 23 start-page: 2377 year: 2008 end-page: 2383 article-title: Effects of contact location and voltage amplitude on speech and movement in bilateral subthalamic nucleus deep brain stimulation publication-title: Mov Disord – volume: 19 start-page: 163 year: 2003 end-page: 179 article-title: The functional anatomy of parkinsonian bradykinesia publication-title: Neuroimage – volume: 51 start-page: 745 year: 1988 end-page: 752 article-title: The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease publication-title: J Neurol Neurosurg Psychiatry – volume: 63 start-page: 363 year: 1994 end-page: 379 article-title: The organization of the basal ganglia‐thalamocortical circuits: open interconnected rather than closed segregated publication-title: Neuroscience – volume: 18 start-page: 146 year: 2009 end-page: 161 article-title: A noninvasive imaging approach to understanding speech changes following deep brain stimulation in Parkinson's disease publication-title: Am J Speech Lang Pathol – volume: 21 start-page: S238 year: 2006 end-page: S246 article-title: Anatomy and physiology of the basal ganglia: implications for deep brain stimulation for Parkinson's disease publication-title: Mov Disord – volume: 116 start-page: 101 year: 1994 end-page: 132 article-title: Dual‐task interference in simple tasks: data and theory publication-title: Psychol Bull – volume: 31 start-page: 222 year: 2010 end-page: 236 article-title: Neural correlates of efficacy of voice therapy in Parkinson's disease identified by performance‐correlation analysis publication-title: Hum Brain Map – volume: 125 start-page: 276 year: 2002 end-page: 289 article-title: Attention to action in Parkinson's disease. Impaired effective connectivity among frontal cortical regions publication-title: Brain – volume: 35 start-page: 222 year: 2007 end-page: 233 article-title: Role of hyperactive cerebellum and motor cortex in Parkinson's disease publication-title: Neuroimage – year: 1988 – year: 2004 – volume: 23 start-page: S8 year: 2000 end-page: S19 article-title: Pathophysiology of the basal ganglia in Parkinson's disease publication-title: Trends Neurosci – volume: 28 start-page: 2250 year: 2005 end-page: 2259 article-title: A functional MRI study of automatic movements in patients with Parkinson's disease publication-title: Brain – volume: 129 start-page: 2667 year: 2006 end-page: 2678 article-title: Network modulation in the treatment of Parkinson's disease publication-title: Brain – volume: 31 start-page: 301 year: 2006 end-page: 307 article-title: Network modulation by the subthalamic nucleus in the treatment of Parkinson's disease publication-title: Neuroimage – volume: 22 start-page: 2043 year: 2007 end-page: 2051 article-title: Functional abnormalities in the primary orofacial sensorimotor cortex during speech in Parkinson's disease publication-title: Mov Disord – start-page: 153 year: 1987 end-page: 164 – volume: 79 start-page: 760 year: 2008 end-page: 766 article-title: Neural correlates of dual task performance in patients with Parkinson's disease publication-title: J Neurol Neurosurg Psychiatry – volume: 23 start-page: 2312 year: 2008 end-page: 2318 article-title: Walking speed during single and dual tasks in Parkinson's disease: which characteristics are important? publication-title: Mov Disord – volume: 31 start-page: 265 year: 2008 end-page: 272 article-title: Cerebellar contributions to speech production and speech perception: psycholinguistic and neurobiological perspectives publication-title: Trends Neurosci – volume: 82 start-page: 65 year: 2002 end-page: 74 article-title: Speech perception deficits in Parkinson's disease: underestimation of time intervals compromises identification of durational phonetic contrasts publication-title: Brain Lang – volume: 60 start-page: 432 year: 2003 end-page: 440 article-title: Hypophonia in Parkinson's disease: neural correlates of voice treatment revealed by PET publication-title: Neurology – volume: 127 start-page: 602 year: 2004 end-page: 615 article-title: Subthalamic nucleus stimulation and dysarthria in Parkinson's disease: a PET study publication-title: Brain – volume: 2 start-page: 189 year: 1995 end-page: 210 article-title: Statistical parametric maps in functional imaging: a general linear approach publication-title: Hum Brain Map – volume: 88 start-page: 224 year: 2010 end-page: 233 article-title: Patient‐specific model‐based investigation of speech intelligibility and movement during deep brain stimulation publication-title: Stereotact Funct Neurosurg – ident: e_1_2_8_7_2 doi: 10.1016/j.neuroimage.2006.11.047 – ident: e_1_2_8_25_2 doi: 10.1016/S1471-1931(00)00028-8 – ident: e_1_2_8_26_2 doi: 10.1002/mds.20958 – ident: e_1_2_8_6_2 doi: 10.1093/brain/awh569 – ident: e_1_2_8_27_2 doi: 10.1016/0306-4522(94)90536-3 – ident: e_1_2_8_3_2 doi: 10.1093/brain/123.2.394 – ident: e_1_2_8_23_2 doi: 10.1159/000314357 – ident: e_1_2_8_32_2 doi: 10.1136/jnnp.2007.126599 – ident: e_1_2_8_24_2 doi: 10.1016/0166-2236(90)90107-L – ident: e_1_2_8_2_2 doi: 10.1093/brain/118.4.913 – ident: e_1_2_8_10_2 doi: 10.1093/brain/awh074 – volume-title: World Medical Association General Assembly. Declaration of Helsinki, Amendment year: 2004 ident: e_1_2_8_16_2 – ident: e_1_2_8_19_2 doi: 10.1093/brain/awl162 – ident: e_1_2_8_9_2 doi: 10.1002/hbm.20859 – volume: 116 start-page: 101 year: 1994 ident: e_1_2_8_34_2 article-title: Dual‐task interference in simple tasks: data and theory publication-title: Psychol Bull doi: 10.1037/0033-2909.116.2.220 – ident: e_1_2_8_14_2 doi: 10.1136/jnnp.51.6.745 – ident: e_1_2_8_15_2 doi: 10.1111/j.1600-0404.2007.00818.x – ident: e_1_2_8_21_2 doi: 10.1016/j.tins.2008.02.011 – ident: e_1_2_8_13_2 doi: 10.1002/mds.21548 – ident: e_1_2_8_28_2 doi: 10.1016/S0093-934X(02)00002-0 – ident: e_1_2_8_5_2 doi: 10.1093/brain/awf036 – ident: e_1_2_8_30_2 doi: 10.1111/j.1468-1331.2009.02612.x – ident: e_1_2_8_22_2 doi: 10.1002/mds.22296 – ident: e_1_2_8_29_2 doi: 10.1523/JNEUROSCI.5441-06.2007 – ident: e_1_2_8_20_2 doi: 10.1016/j.neuroimage.2005.12.024 – ident: e_1_2_8_33_2 doi: 10.1002/mds.22219 – ident: e_1_2_8_11_2 doi: 10.1044/1058-0360(2008/08-0004) – ident: e_1_2_8_8_2 doi: 10.1212/WNL.60.3.432 – ident: e_1_2_8_31_2 doi: 10.1002/1531-8249(200008)48:2<268::AID-ANA21>3.0.CO;2-4 – ident: e_1_2_8_12_2 doi: 10.1016/j.jns.2008.06.024 – ident: e_1_2_8_17_2 doi: 10.1002/hbm.460020402 – ident: e_1_2_8_4_2 doi: 10.1016/S1053-8119(03)00059-4 – volume-title: Co‐planar Stereotaxic Atlas of the Human Brain year: 1988 ident: e_1_2_8_18_2 |
| SSID | ssj0011516 |
| Score | 2.1885536 |
| Snippet | Among the repertoire of motor functions, although hand movement and speech production tasks have been investigated widely by functional neuroimaging, paradigms... |
| SourceID | proquest pubmed pascalfrancis crossref wiley istex |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 2212 |
| SubjectTerms | Acoustic Stimulation Adult Aged Biological and medical sciences Brain - blood supply Brain - pathology Brain - physiopathology Brain Mapping Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases dual task Female Functional Laterality functional magnetic resonance imaging Hand - physiopathology hand movement Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging - methods Male Medical sciences Middle Aged Movement - physiology Neurology Neuropsychological Tests Oxygen - blood Parkinson Disease - pathology Parkinson Disease - physiopathology Parkinson's disease Photic Stimulation Psychomotor Performance - physiology Speech speech production |
| Title | Functional magnetic resonance imaging exploration of combined hand and speech movements in Parkinson's disease |
| URI | https://api.istex.fr/ark:/67375/WNG-J87FH449-X/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fmds.23799 https://www.ncbi.nlm.nih.gov/pubmed/21714000 https://www.proquest.com/docview/900638375 |
| Volume | 26 |
| WOSCitedRecordID | wos000296610900015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVWIB databaseName: Wiley Online Library Full Collection 2020 customDbUrl: eissn: 1531-8257 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0011516 issn: 0885-3185 databaseCode: DRFUL dateStart: 19990101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB61uwhxobwJj5WFEHAJTWxvbKsnRAkVoisEVOzNih2nXYlNqmaL-PmMnUe1UpGQOETKwU7i8Uzmsz3zDcBLYQ2nhRJxZksW8yyzseGqiguO6L9QlhllQrEJsVjI5VJ92YGDIRem44cYN9y8ZYT_tTfwwrT7V6Sh67J9S5lQahemFPWWT2B6-DU_-TweIqAzyzoQOQ9JwgOxUEL3x85b7mjqJfvbh0cWLUqo6kpbXIc9t6Fs8EX53n-N4g7c7iEoedfpzF3YcfU9uHncH7LfhzpHX9dtEZJ1cVr7NEeCq_LGc3M4slqHwkbEhei9MLGkqQi-GBfZriR-K574qz13zp6RdRMoyTctWdXEJ1mHfLPXLenPhh7ASf7h-_ujuC_LEFuumI-USJRNneTUlfMkcRmzxpSJSSonpUmpc2klSikRKTpWUZkZhDGmzBQX1gkm2EOY1E3tHgORwiBgEmXlecVSi1jVL7dUxV1iDK50IngzzI62PWe5L53xU3dsy1Sj_HSQXwQvxqbnHVHHdY1ehSkeW-CgfWSbmOsfi4_6kxT5EedKLyOYbenA2IFykXDOsgjIoBQaDdKfshS1ay5brQIKxEdG8KhTlqvOvto8-iAcVtCJv3-oPj78Fm6e_HvTp3CLDgGK6TOYbC4u3XO4YX9tVu3FDHbFUs56E_kD82QS6g |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB6VXUS58H6ER7EQAi6hieONbYkLooQFdlcIWnVvVuw4ZSU2qZot4uczdh7VSkVC4hApBzuJ7ZnM5_HMNwAvuNGM5pKHqSmSkKWpCTWTZZgzRP-5NImW2heb4IuFWC7l1x142-fCtPwQg8PNaYb_XzsFdw7p_QvW0HXRvKEJl_IKjBmK0WQE44Nv2dFsOEVAa5a2KHLis4R7ZqGI7g-dt-zR2E3tbxcfmTc4RWVb2-Iy8LmNZb0xym7-3zBuwY0OhJJ3rdTchh1b3YFr8-6Y_S5UGVq71klI1vlJ5RIdCe7La8fOYclq7UsbEevj9_zSkrok-GbcZtuCOGc8cVdzaq35Qda1JyXfNGRVEZdm7TPOXjWkOx26B0fZh8P307ArzBAaJhMXKxFJE1vBqC0mUWTTxGhdRDoqrRA6ptbGJS-EQKxok5KKVCOQ0UUqGTeWJzy5D6OqruxDIIJrhEy8KB2zWGwQrboNlyyZjbTGvU4Ar_vlUaZjLXfFM36qlm-ZKpw_5ecvgOdD09OWquOyRi_9Gg8tcNAuto1P1PHio_oseDZlTKplAHtbQjB0oIxHjCVpAKSXCoUq6c5Z8srW542SHgfiIwN40ErLRWdXbx6tEA7LC8XfP1TND777m0f_3vQZ7E4P5zM1-7T48hiu0z5cMX4Co83ZuX0KV82vzao52-s05Q_jzRXy |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB6VLqq4lDekQLEQAi6heXjjWOKCWEKBdlUBVfdmxc6kXYlNVs226s9n7DyqlYqExCFSDnYS2zOZb-yZbwBeC6N5lEvhJ6aIfZ4kxtdcln7OCf3n0sRaaldsQkyn6WwmjzbgQ58L0_JDDBtuVjPc_9oqOC6Lcu-aNXRRNO-jWEh5C0Z8LBNSy9HkR3Z8MJwikDVLWhQ5dlnCPbNQEO0Nndfs0chO7ZWNj8wbmqKyrW1xE_hcx7LOGGV3_28Y92C7A6HsYys192EDqwewddgdsz-EKiNr124SskV-WtlER0Z-eW3ZOZDNF660EUMXv-eWltUlozeTm40Fs5vxzF7NEtGcsUXtSMlXDZtXzKZZu4yztw3rTocewXH2-denfb8rzOAbLmMbKxFIE2LKIyzGQYBJbLQuAh2UmKY6jBDDUhRpSlgR4zJKE01ARheJ5MKgiEX8GDarusKnwFKhCTKJorTMYqEhtGodLllyDLQmX8eDd_3yKNOxltviGb9Vy7ccKZo_5ebPg1dD02VL1XFTozdujYcWNGgb2ybG6mT6RX1LRbbPuVQzD3bXhGDoEHERcB4nHrBeKhSppD1nySusLxolHQ6kR3rwpJWW68623jxZIRqWE4q_f6g6nPx0Nzv_3vQlbB1NMnXwdfr9GdyJ-mjF8Dlsrs4v8AXcNpereXO-2ynKH1CHFW0 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Functional+magnetic+resonance+imaging+exploration+of+combined+hand+and+speech+movements+in+Parkinson%27s+disease&rft.jtitle=Movement+disorders&rft.au=Pinto%2C+Serge&rft.au=Mancini%2C+Laura&rft.au=Jahanshahi%2C+Marjan&rft.au=Thornton%2C+John+S&rft.date=2011-10-01&rft.issn=1531-8257&rft.eissn=1531-8257&rft.volume=26&rft.issue=12&rft.spage=2212&rft_id=info:doi/10.1002%2Fmds.23799&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0885-3185&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0885-3185&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0885-3185&client=summon |