Functional magnetic resonance imaging exploration of combined hand and speech movements in Parkinson's disease
Among the repertoire of motor functions, although hand movement and speech production tasks have been investigated widely by functional neuroimaging, paradigms combining both movements have been studied less so. Such paradigms are of particular interest in Parkinson's disease, in which patients...
Saved in:
| Published in: | Movement disorders Vol. 26; no. 12; pp. 2212 - 2219 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.10.2011
Wiley |
| Subjects: | |
| ISSN: | 0885-3185, 1531-8257, 1531-8257 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Among the repertoire of motor functions, although hand movement and speech production tasks have been investigated widely by functional neuroimaging, paradigms combining both movements have been studied less so. Such paradigms are of particular interest in Parkinson's disease, in which patients have specific difficulties performing two movements simultaneously. In 9 unmedicated patients with Parkinson's disease and 15 healthy control subjects, externally cued tasks (i.e., hand movement, speech production, and combined hand movement and speech production) were performed twice in a random order and functional magnetic resonance imaging detected cerebral activations, compared to the rest. F‐statistics tested within‐group (significant activations at P values < 0.05, familywise error corrected), between‐group, and between‐task comparisons (regional activations significant at P values < 0.001, uncorrected, with cluster size > 10 voxels). For control subjects, the combined task activations comprised the sum of those obtained during hand movement and speech production performed separately, reflecting the neural correlates of performing movements sharing similar programming modalities. In patients with Parkinson's disease, only activations underlying hand movement were observed during the combined task. We interpreted this phenomenon as patients' potential inability to recruit facilitatory activations while performing two movements simultaneously. This lost capacity could be related to a functional prioritization of one movement (i.e., hand movement), in comparison with the other (i.e., speech production). Our observation could also reflect the inability of patients with Parkinson's disease to intrinsically engage the motor coordination necessary to perform a combined task. © 2011 Movement Disorder Society |
|---|---|
| Bibliography: | Full financial disclosures and author roles may be found in the online version of this article. Relevant conflicts of interest/financial disclosures: Nothing to report. ArticleID:MDS23799 ark:/67375/WNG-J87FH449-X Funding agencies: Fondation Simone et Cino Del Duca, The Wellcome Trust, Medtronic, National Institutes of Health (Bethesda, MD) contracts RO1-NS40902 (PI: Daniel Corcos) and RO1-NS40856-02 (PI: M.J.), the Parkinson's Disease Society UK, and the Parkinson's Appeal. This work was undertaken at UCLH/UCL, which received a proportion of funding from the Department of Health's NIHR Biomedical Research Centers funding scheme. istex:7E42461455C59B1B37A4EF0EECE281E61FA5FABB Nothing to report. Relevant conflicts of interest/financial disclosures Funding agencies Fondation Simone et Cino Del Duca, The Wellcome Trust, Medtronic, National Institutes of Health (Bethesda, MD) contracts RO1‐NS40902 (PI: Daniel Corcos) and RO1‐NS40856‐02 (PI: M.J.), the Parkinson's Disease Society UK, and the Parkinson's Appeal. This work was undertaken at UCLH/UCL, which received a proportion of funding from the Department of Health's NIHR Biomedical Research Centers funding scheme. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 0885-3185 1531-8257 1531-8257 |
| DOI: | 10.1002/mds.23799 |