CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma

CXCR2 has been suggested to have both tumor-promoting and tumor-suppressive properties. Here we show that CXCR2 signaling is upregulated in human pancreatic cancer, predominantly in neutrophil/myeloid-derived suppressor cells, but rarely in tumor cells. Genetic ablation or inhibition of CXCR2 abroga...

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Veröffentlicht in:	Cancer cell Jg. 29; H. 6; S. 832
Hauptverfasser:	Steele, Colin W, Karim, Saadia A, Leach, Joshua D G, Bailey, Peter, Upstill-Goddard, Rosanna, Rishi, Loveena, Foth, Mona, Bryson, Sheila, McDaid, Karen, Wilson, Zena, Eberlein, Catherine, Candido, Juliana B, Clarke, Mairi, Nixon, Colin, Connelly, John, Jamieson, Nigel, Carter, C Ross, Balkwill, Frances, Chang, David K, Evans, T R Jeffry, Strathdee, Douglas, Biankin, Andrew V, Nibbs, Robert J B, Barry, Simon T, Sansom, Owen J, Morton, Jennifer P
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 13.06.2016
Schlagworte:	Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal, Humanized Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - pathology Cell Line, Tumor Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Gemcitabine Gene Expression Regulation, Neoplastic - drug effects Humans Immunotherapy Mice Neoplasm Metastasis Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Prognosis Receptors, Interleukin-8B - antagonists & inhibitors Receptors, Interleukin-8B - genetics Signal Transduction Small Molecule Libraries - administration & dosage Small Molecule Libraries - pharmacology Survival Analysis Up-Regulation Xenograft Model Antitumor Assays
ISSN:	1878-3686, 1878-3686
Online-Zugang:	Weitere Angaben
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