Mendelian randomization with a binary exposure variable: interpretation and presentation of causal estimates

Mendelian randomization uses genetic variants to make causal inferences about a modifiable exposure. Subject to a genetic variant satisfying the instrumental variable assumptions, an association between the variant and outcome implies a causal effect of the exposure on the outcome. Complications ari...

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Bibliographic Details
Published in:	European journal of epidemiology Vol. 33; no. 10; pp. 947 - 952
Main Authors:	Burgess, Stephen, Labrecque, Jeremy A.
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer 01.10.2018 Springer Netherlands Springer Nature B.V
Subjects:	Blood Pressure Cardiology Epidemiology Exposure Genetic diversity Genetic variance Genetic Variation Humans Hypertension Infectious Diseases Likelihood Functions Medicine Medicine & Public Health Mendelian Randomization Analysis - methods METHODS Models, Genetic Models, Statistical Oncology Public Health Random Allocation Randomization Risk Factors Subgroups Causal inference Instrumental variable Effect estimation Mendelian randomization Genetic epidemiology
ISSN:	0393-2990, 1573-7284, 1573-7284
Online Access:	Get full text
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