SGLT2 inhibitors attenuate endothelial to mesenchymal transition and cardiac fibroblast activation

Beneficial effects of sodium glucose co-transporter 2 inhibitors (SGLT2is) in cardiovascular diseases have been extensively reported leading to the inclusion of these drugs in the treatment guidelines for heart failure. However, molecular actions especially on non-myocyte cells remain uncertain. We...

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Bibliographic Details
Published in:	Scientific reports Vol. 14; no. 1; pp. 16459 - 15
Main Authors:	Schmidt, Kevin, Schmidt, Arne, Groß, Sonja, Just, Annette, Pfanne, Angelika, Fuchs, Maximilian, Jordan, Maria, Mohr, Elisa, Pich, Andreas, Fiedler, Jan, Thum, Thomas
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 16.07.2024 Nature Publishing Group Nature Portfolio
Subjects:	631/92/436 631/92/475 631/92/609 631/92/613 692/4017 692/4019 Actin Benzhydryl Compounds - pharmacology Cardiovascular diseases Cell migration Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Congestive heart failure Cytoskeleton Electron transport Endothelial cell Endothelial cells Epithelial-Mesenchymal Transition - drug effects Fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Fibrosis Glucose transporter Glucosides - pharmacology Heart diseases Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humanities and Social Sciences Humans Inflammation Mode of action multidisciplinary Myocytes Na+/H+-exchanging ATPase Oxygen consumption Proteomics Science Science (multidisciplinary) siRNA Sodium Sodium-glucose transporter 2 inhibitors Sodium-Glucose Transporter 2 Inhibitors - pharmacology Sodium-Hydrogen Exchanger 1 - antagonists & inhibitors Sodium-Hydrogen Exchanger 1 - metabolism Umbilical vein Sodium-glucose transporter 2 inhibitors Endothelial cell Fibroblasts Oxygen consumption Inflammation Cardiovascular diseases Cell migration
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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