Stroma in normal and cancer wound healing

It is currently believed that stroma, the connective framework of biological tissues, plays a central role in normal wound healing and in cancer. In both these contexts, stromal cellular components such as activated fibroblasts interact with complex protein networks that include growth factors, stru...

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Vydané v:	The FEBS journal Ročník 286; číslo 15; s. 2909 - 2920
Hlavní autori:	Huet, Eric, Jaroz, Camille, Nguyen, Hoang Quy, Belkacemi, Yazid, Taille, Alexandre, Stavrinides, Vasilis, Whitaker, Hayley
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Blackwell Publishing Ltd 01.08.2019
Predmet:	Animals Cancer cancer‐associated fibroblasts Cell proliferation Cellular communication Connective Tissue - metabolism Connective Tissue - pathology Connective Tissue - radiation effects Crosstalk EMMPRIN Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism FAPα Fibroblasts fibrosis Growth factors Humans Metastases metastasis myofibroblasts neoplasm cells neoplasms Neoplasms - metabolism Neoplasms - radiotherapy proteinases Proteins Radiation Injuries - etiology Radiation Injuries - metabolism Radiation therapy radiotherapy Radiotherapy - adverse effects Signal Transduction structural proteins TGFβ Therapeutic applications tissue repair Tissues tumour microenvironment Wound Healing cancer-associated fibroblasts fibroblasts wound healing TGFβ radiotherapy EMMPRIN fibrosis tumour microenvironment FAPα myofibroblasts
ISSN:	1742-464X, 1742-4658, 1742-4658
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Shrnutí:	It is currently believed that stroma, the connective framework of biological tissues, plays a central role in normal wound healing and in cancer. In both these contexts, stromal cellular components such as activated fibroblasts interact with complex protein networks that include growth factors, structural protein or proteinases in order to initiate and sustain an extensive remodelling process. However, although this process is usually spatially and temporally self‐limited, it is unregulated in the case of cancer and leads to uncontrolled cell proliferation and invasion within tissues, metastasis and therapeutic resistance. In this review, we outline the role of stroma in normal healing, cancer and post radiotherapy, with a particular focus on the crosstalk between normal or cancer cells and fibroblasts. Understanding these mechanisms is particularly important as several stromal components have been proposed as potential therapeutic targets. Stromal modification, a key step in the control of wound healing, tumour progression and radiation‐induced fibrosis, is characterized by the differentiation of quiescent fibroblasts into an activated state, which results in crosstalk among fibroblasts and normal or cancer cells. Understanding these activation mechanisms, which involve extracellular matrix metalloproteinase inducer and transforming growth factor beta, is important because several stromal components are potential therapeutic targets.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1742-464X 1742-4658 1742-4658
DOI:	10.1111/febs.14842