Long-term follow-up study of clear cell papulosis

Clear cell papulosis (CCP) was described as a new entity in 1987. Since then, only case reports or small case series have appeared in the literature and the long-term outcome of CCP remains unknown. The aim of this study was to review cases of CCP diagnosed at our institution and to investigate thei...

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Veröffentlicht in:	Journal of the American Academy of Dermatology Jg. 63; H. 2; S. 266 - 273
Hauptverfasser:	Tseng, Fang-Wen, Kuo, Tseng-Tong, Lu, Pei-Hsuan, Chan, Heng-Leong, Chan, Ming-Jing, Hui, Rosaline Chung-Yee
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York, NY Mosby, Inc 01.08.2010 Elsevier
Schlagworte:	Biological and medical sciences Carcinoembryonic Antigen - metabolism Child, Preschool clear cell papulosis clear cells of Toker Dermatology Disease Progression extramammary Paget disease Female Follow-Up Studies Humans Hypopigmentation - metabolism Hypopigmentation - pathology Immunohistochemistry Infant long-term follow-up Male Medical sciences milk line Mucin-1 - metabolism Paget Disease, Extramammary - pathology Pigmentary diseases of the skin Remission, Spontaneous Retrospective Studies Skin - metabolism Skin - pathology Skin Diseases, Papulosquamous - metabolism Skin Diseases, Papulosquamous - pathology Staining and Labeling Time Factors MPD CCP milk line PAS clear cells of Toker long-term follow-up EMA clear cell papulosis EMPD extramammary Paget disease CEA carcinoembryonic antigen periodic acid–Schiff mammary Paget disease epithelial membrane antigen Skin disease Pigmentation disorder Clear cell papulosis Dermatology Follow up study Long term
ISSN:	0190-9622, 1097-6787, 1097-6787
Online-Zugang:	Volltext
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Zusammenfassung:	Clear cell papulosis (CCP) was described as a new entity in 1987. Since then, only case reports or small case series have appeared in the literature and the long-term outcome of CCP remains unknown. The aim of this study was to review cases of CCP diagnosed at our institution and to investigate their outcome. Nineteen patients given a diagnosis of CCP more than 6 years previously were identified. Their medical records and histopathologic findings were reviewed. With a median follow-up duration of 11.5 years, regression of skin lesions was observed in 85.7% of patients. Persistence of skin lesions 11.5 years after diagnosis was confirmed histopathologically in one case, with a reduction in clear cell density. Retrospective nature of the study is a limitation. No treatment is necessary for CCP because the skin lesions are asymptomatic and most patients experience at least partial regression.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0190-9622 1097-6787 1097-6787
DOI:	10.1016/j.jaad.2009.08.056