The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth

Cell polarity is an important feature of many tissues and is often disrupted in cancer; the TNF receptor Grindelwald is now shown to have an important role in coordinating cell polarity and neoplastic growth in a Drosophila model. Linking cell polarity and neoplasia Cell polarity is an important fea...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Nature (London) Ročník 522; číslo 7557; s. 482 - 486
Hlavní autori:	Andersen, Ditte S., Colombani, Julien, Palmerini, Valentina, Chakrabandhu, Krittalak, Boone, Emilie, Röthlisberger, Michael, Toggweiler, Janine, Basler, Konrad, Mapelli, Marina, Hueber, Anne-Odile, Léopold, Pierre
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 25.06.2015 Nature Publishing Group
Predmet:	631/80/304 Amino Acid Sequence Animals Apoptosis Apoptosis - genetics Biochemistry, Molecular Biology Cancer Cell Adhesion Molecules Cell Adhesion Molecules - metabolism Cell Division Cell Division - genetics Cell Polarity Cell Polarity - genetics Cell Transformation, Neoplastic Cell Transformation, Neoplastic - genetics Cloning Development Biology Disease Models, Animal Drosophila melanogaster Drosophila melanogaster - cytology Drosophila melanogaster - enzymology Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins Drosophila Proteins - chemistry Drosophila Proteins - deficiency Drosophila Proteins - genetics Drosophila Proteins - metabolism Female Genes Genomics Genotype & phenotype Humanities and Social Sciences Humans Insects JNK Mitogen-Activated Protein Kinases JNK Mitogen-Activated Protein Kinases - metabolism letter Life Sciences Male MAP Kinase Signaling System Matrix Metalloproteinase 1 Matrix Metalloproteinase 1 - metabolism Membrane Proteins Membrane Proteins - chemistry Membrane Proteins - deficiency Membrane Proteins - genetics Membrane Proteins - metabolism Molecular Sequence Data multidisciplinary Neoplasm Invasiveness Neoplasm Invasiveness - genetics Neoplasms Neoplasms - enzymology Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Proteins ras Proteins ras Proteins - genetics ras Proteins - metabolism Receptors, Tumor Necrosis Factor Receptors, Tumor Necrosis Factor - chemistry Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor - metabolism Science Tumors
ISSN:	0028-0836, 1476-4687, 1476-4687
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Abstract	Cell polarity is an important feature of many tissues and is often disrupted in cancer; the TNF receptor Grindelwald is now shown to have an important role in coordinating cell polarity and neoplastic growth in a Drosophila model. Linking cell polarity and neoplasia Cell polarity is an important feature of many tissues, and is often disrupted in cancer. This study demonstrates, in a Drosophila model, that the tumour necrosis factor receptor molecule Grindelwald plays an important role in coordinating cell polarity and neoplastic growth. The authors identify Grindelwald as the long-sought receptor for the apoptosis-inducing factor Eiger, and show that Grindelwald functions by integrating signals from Eiger as well as from cell polarity cues. Disruption of epithelial polarity is a key event in the acquisition of neoplastic growth. JNK signalling is known to play an important part in driving the malignant progression of many epithelial tumours, although the link between loss of polarity and JNK signalling remains elusive. In a Drosophila genome-wide genetic screen designed to identify molecules implicated in neoplastic growth 1 , we identified grindelwald ( grnd ), a gene encoding a transmembrane protein with homology to members of the tumour necrosis factor receptor (TNFR) superfamily. Here we show that Grnd mediates the pro-apoptotic functions of Eiger (Egr), the unique Drosophila TNF, and that overexpression of an active form of Grnd lacking the extracellular domain is sufficient to activate JNK signalling in vivo . Grnd also promotes the invasiveness of Ras V12 /scrib −/− tumours through Egr-dependent Matrix metalloprotease-1 (Mmp1) expression. Grnd localizes to the subapical membrane domain with the cell polarity determinant Crumbs (Crb) and couples Crb-induced loss of polarity with JNK activation and neoplastic growth through physical interaction with Veli (also known as Lin-7). Therefore, Grnd represents the first example of a TNFR that integrates signals from both Egr and apical polarity determinants to induce JNK-dependent cell death or tumour growth.
AbstractList	Cell polarity is an important feature of many tissues and is often disrupted in cancer; the TNF receptor Grindelwald is now shown to have an important role in coordinating cell polarity and neoplastic growth in a Drosophila model. Linking cell polarity and neoplasia Cell polarity is an important feature of many tissues, and is often disrupted in cancer. This study demonstrates, in a Drosophila model, that the tumour necrosis factor receptor molecule Grindelwald plays an important role in coordinating cell polarity and neoplastic growth. The authors identify Grindelwald as the long-sought receptor for the apoptosis-inducing factor Eiger, and show that Grindelwald functions by integrating signals from Eiger as well as from cell polarity cues. Disruption of epithelial polarity is a key event in the acquisition of neoplastic growth. JNK signalling is known to play an important part in driving the malignant progression of many epithelial tumours, although the link between loss of polarity and JNK signalling remains elusive. In a Drosophila genome-wide genetic screen designed to identify molecules implicated in neoplastic growth 1 , we identified grindelwald ( grnd ), a gene encoding a transmembrane protein with homology to members of the tumour necrosis factor receptor (TNFR) superfamily. Here we show that Grnd mediates the pro-apoptotic functions of Eiger (Egr), the unique Drosophila TNF, and that overexpression of an active form of Grnd lacking the extracellular domain is sufficient to activate JNK signalling in vivo . Grnd also promotes the invasiveness of Ras V12 /scrib −/− tumours through Egr-dependent Matrix metalloprotease-1 (Mmp1) expression. Grnd localizes to the subapical membrane domain with the cell polarity determinant Crumbs (Crb) and couples Crb-induced loss of polarity with JNK activation and neoplastic growth through physical interaction with Veli (also known as Lin-7). Therefore, Grnd represents the first example of a TNFR that integrates signals from both Egr and apical polarity determinants to induce JNK-dependent cell death or tumour growth. Disruption of epithelial polarity is a key event in the acquisition of neoplastic growth. JNK signalling is known to play an important part in driving the malignant progression of many epithelial tumours, although the link between loss of polarity and JNK signalling remains elusive. In a Drosophila genome-wide genetic screen designed to identify molecules implicated in neoplastic growth, we identified grindelwald (grnd), a gene encoding a transmembrane protein with homology to members of the tumour necrosis factor receptor (TNFR) superfamily. Here we show that Grnd mediates the pro-apoptotic functions of Eiger (Egr), the unique Drosophila TNF, and that overexpression of an active form of Grnd lacking the extracellular domain is sufficient to activate JNK signalling in vivo. Grnd also promotes the invasiveness of Ras(V12)/scrib(-/-) tumours through Egr-dependent Matrix metalloprotease-1 (Mmp1) expression. Grnd localizes to the subapical membrane domain with the cell polarity determinant Crumbs (Crb) and couples Crb-induced loss of polarity with JNK activation and neoplastic growth through physical interaction with Veli (also known as Lin-7). Therefore, Grnd represents the first example of a TNFR that integrates signals from both Egr and apical polarity determinants to induce JNK-dependent cell death or tumour growth. Disruption of epithelial polarity is a key event in the acquisition of neoplastic growth. JNK signalling is known to play an important part in driving the malignant progression of many epithelial tumours, although the link between loss of polarity and JNK signalling remains elusive. In a Drosophila genome-wide genetic screen designed to identify molecules implicated in neoplastic growth1, we identified grindelwald (grnd), a gene encoding a transmembrane protein with homology to members of the tumour necrosis factor receptor (TNFR) superfamily. Here we show that Grnd mediates the pro-apoptotic functions of Eiger (Egr), the unique Drosophila TNF, and that overexpression of an active form of Grnd lacking the extracellular domain is sufficient to activate JNK signalling in vivo. Grnd also promotes the invasiveness of Ras^sup V12^/scrib^sup -/-^ tumours through Egr-dependent Matrix metallo-protease- 1 (Mmp1) expression. Grnd localizes to the subapical membrane domain with the cell polarity determinant Crumbs (Crb) and couples Crb-induced loss of polarity with JNK activation and neoplastic growth through physical interaction with Veli (also known as Lin-7). Therefore, Grnd represents the first example of a TNFR that integrates signals from both Egr and apical polarity determinants to induce JNK-dependent cell death or tumour growth. Disruption of epithelial polarity is a key event in the acquisition of neoplastic growth. JNK signalling is known to play an important part in driving the malignant progression of many epithelial tumours, although the link between loss of polarity and JNK signalling remains elusive. In a Drosophila genome-wide genetic screen designed to identify molecules implicated in neoplastic growth, we identified grindelwald (grnd), a gene encoding a transmembrane protein with homology to members of the tumour necrosis factor receptor (TNFR) superfamily. Here we show that Grnd mediates the pro-apoptotic functions of Eiger (Egr), the unique Drosophila TNF, and that overexpression of an active form of Grnd lacking the extracellular domain is sufficient to activate JNK signalling in vivo. Grnd also promotes the invasiveness of Ras(V12)/scrib(-/-) tumours through Egr-dependent Matrix metalloprotease-1 (Mmp1) expression. Grnd localizes to the subapical membrane domain with the cell polarity determinant Crumbs (Crb) and couples Crb-induced loss of polarity with JNK activation and neoplastic growth through physical interaction with Veli (also known as Lin-7). Therefore, Grnd represents the first example of a TNFR that integrates signals from both Egr and apical polarity determinants to induce JNK-dependent cell death or tumour growth.Disruption of epithelial polarity is a key event in the acquisition of neoplastic growth. JNK signalling is known to play an important part in driving the malignant progression of many epithelial tumours, although the link between loss of polarity and JNK signalling remains elusive. In a Drosophila genome-wide genetic screen designed to identify molecules implicated in neoplastic growth, we identified grindelwald (grnd), a gene encoding a transmembrane protein with homology to members of the tumour necrosis factor receptor (TNFR) superfamily. Here we show that Grnd mediates the pro-apoptotic functions of Eiger (Egr), the unique Drosophila TNF, and that overexpression of an active form of Grnd lacking the extracellular domain is sufficient to activate JNK signalling in vivo. Grnd also promotes the invasiveness of Ras(V12)/scrib(-/-) tumours through Egr-dependent Matrix metalloprotease-1 (Mmp1) expression. Grnd localizes to the subapical membrane domain with the cell polarity determinant Crumbs (Crb) and couples Crb-induced loss of polarity with JNK activation and neoplastic growth through physical interaction with Veli (also known as Lin-7). Therefore, Grnd represents the first example of a TNFR that integrates signals from both Egr and apical polarity determinants to induce JNK-dependent cell death or tumour growth.
Author	Basler, Konrad Chakrabandhu, Krittalak Mapelli, Marina Boone, Emilie Palmerini, Valentina Röthlisberger, Michael Léopold, Pierre Toggweiler, Janine Colombani, Julien Andersen, Ditte S. Hueber, Anne-Odile
Author_xml	– sequence: 1 givenname: Ditte S. surname: Andersen fullname: Andersen, Ditte S. organization: University of Nice-Sophia Antipolis, Institute of Biology Valrose, CNRS, Institute of Biology Valrose, INSERM, Institute of Biology Valrose, Genetics and Physiology of Growth laboratory, Institute of Biology Valrose – sequence: 2 givenname: Julien surname: Colombani fullname: Colombani, Julien email: julien.colombani@unice.fr organization: University of Nice-Sophia Antipolis, Institute of Biology Valrose, CNRS, Institute of Biology Valrose, INSERM, Institute of Biology Valrose, Genetics and Physiology of Growth laboratory, Institute of Biology Valrose – sequence: 3 givenname: Valentina surname: Palmerini fullname: Palmerini, Valentina organization: Department of Experimental Oncology, European Institute of Oncology – sequence: 4 givenname: Krittalak surname: Chakrabandhu fullname: Chakrabandhu, Krittalak organization: University of Nice-Sophia Antipolis, Institute of Biology Valrose, CNRS, Institute of Biology Valrose, INSERM, Institute of Biology Valrose, Death receptors Signalling and Cancer Therapy laboratory, Institute of Biology Valrose – sequence: 5 givenname: Emilie surname: Boone fullname: Boone, Emilie organization: University of Nice-Sophia Antipolis, Institute of Biology Valrose, CNRS, Institute of Biology Valrose, INSERM, Institute of Biology Valrose, Genetics and Physiology of Growth laboratory, Institute of Biology Valrose – sequence: 6 givenname: Michael surname: Röthlisberger fullname: Röthlisberger, Michael organization: Institute of Molecular Life Sciences, University of Zurich – sequence: 7 givenname: Janine surname: Toggweiler fullname: Toggweiler, Janine organization: Institute of Molecular Life Sciences, University of Zurich – sequence: 8 givenname: Konrad surname: Basler fullname: Basler, Konrad organization: Institute of Molecular Life Sciences, University of Zurich – sequence: 9 givenname: Marina surname: Mapelli fullname: Mapelli, Marina organization: Department of Experimental Oncology, European Institute of Oncology – sequence: 10 givenname: Anne-Odile surname: Hueber fullname: Hueber, Anne-Odile organization: University of Nice-Sophia Antipolis, Institute of Biology Valrose, CNRS, Institute of Biology Valrose, INSERM, Institute of Biology Valrose, Death receptors Signalling and Cancer Therapy laboratory, Institute of Biology Valrose – sequence: 11 givenname: Pierre surname: Léopold fullname: Léopold, Pierre email: leopold@unice.fr organization: University of Nice-Sophia Antipolis, Institute of Biology Valrose, CNRS, Institute of Biology Valrose, INSERM, Institute of Biology Valrose, Genetics and Physiology of Growth laboratory, Institute of Biology Valrose
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/25874673$$D View this record in MEDLINE/PubMed https://hal.science/hal-01255294$$DView record in HAL
BookMark	eNp10c1vFCEUAHBiauy2evJuSLzY6CjMMHwcm36abOplPXmYvJmBLg0LIzA2_e_LurVpGnsigd97vI8DtOeD1wi9p-QrJY385iHPUVNWK_kKLSgTvGJcij20IKSWFZEN30cHKd0QQloq2Bu0X7dSMC6aBfq1Wmt8GkMK09o6wKurcxz1oKccIr6I1o_a3YIb8RDmyemEXUgJB4MH7RyegoNo8x0GP2Kvw-QgZTvg6xhu8_otem3AJf3u4TxEP8_PVieX1fLHxfeT42U1MEVzNfa0EcoYZriU9di0teCkPIEo9ZtG9EobGKSg7aj7ETQVwFvoRd9TBUao5hAd7fKuwXVTtBuId10A210eL7vtHaF129aK_aHFftrZKYbfs06529i07QVK-XPqKFeUE8JqWejHZ_QmzNGXTv4qpQglbVEfHtTcb_T4-P-_ERfweQeGMuUUtXkklHTbBXZPFlg0faYHmyHb4HME616I-bKLSSWzv9bxSaH_4fd4dK2z
CODEN	NATUAS
CitedBy_id	crossref_primary_10_1038_s41420_018_0074_1 crossref_primary_10_3389_fonc_2023_1144951 crossref_primary_10_1371_journal_pgen_1008133 crossref_primary_10_7554_eLife_80956 crossref_primary_10_1038_s41467_021_22080_9 crossref_primary_10_1155_2018_7152962 crossref_primary_10_3390_ijms252313110 crossref_primary_10_1111_cpr_13188 crossref_primary_10_3390_ijms21134580 crossref_primary_10_1038_s41598_020_68313_7 crossref_primary_10_3389_fgene_2019_00051 crossref_primary_10_3389_fcell_2020_00042 crossref_primary_10_1016_j_ceb_2017_05_002 crossref_primary_10_1016_j_snb_2021_130397 crossref_primary_10_1038_s41598_017_05482_y crossref_primary_10_3390_cells10113211 crossref_primary_10_1016_j_isci_2023_106440 crossref_primary_10_1038_s41467_023_41549_3 crossref_primary_10_1242_dmm_044669 crossref_primary_10_1002_mgg3_2198 crossref_primary_10_1038_srep34725 crossref_primary_10_1016_j_coi_2024_102502 crossref_primary_10_1016_j_mce_2021_111339 crossref_primary_10_3390_biomedicines11020263 crossref_primary_10_3390_genes14101942 crossref_primary_10_1242_dmm_039727 crossref_primary_10_3390_ijms22115519 crossref_primary_10_1038_s44318_024_00170_w crossref_primary_10_1016_j_dci_2019_01_011 crossref_primary_10_1242_dmm_050388 crossref_primary_10_1038_s41388_021_01831_4 crossref_primary_10_1242_dev_174292 crossref_primary_10_1039_D5CC01905B crossref_primary_10_1080_19336934_2018_1441652 crossref_primary_10_1016_j_devcel_2018_05_012 crossref_primary_10_1111_jcmm_70794 crossref_primary_10_7554_eLife_30391 crossref_primary_10_1038_s41389_024_00530_5 crossref_primary_10_1073_pnas_1701791114 crossref_primary_10_1242_dev_189472 crossref_primary_10_1002_mco2_605 crossref_primary_10_1016_j_cmet_2016_03_003 crossref_primary_10_1016_j_semcdb_2025_103602 crossref_primary_10_1242_dev_201767 crossref_primary_10_1016_j_devcel_2018_04_002 crossref_primary_10_1038_nature21033 crossref_primary_10_1111_cpr_12593 crossref_primary_10_1016_j_snb_2025_137644 crossref_primary_10_1007_s10495_016_1340_4 crossref_primary_10_3390_ijms22168873 crossref_primary_10_1038_s41419_019_2135_7 crossref_primary_10_7554_eLife_26747 crossref_primary_10_1016_j_cub_2025_05_068 crossref_primary_10_1371_journal_pgen_1008062 crossref_primary_10_15252_embj_2020104415 crossref_primary_10_1242_bio_059525 crossref_primary_10_1093_neuonc_noae147 crossref_primary_10_3389_fimmu_2017_01642 crossref_primary_10_3390_ijms222312732 crossref_primary_10_1126_science_abl4213 crossref_primary_10_1186_s13104_018_3350_5 crossref_primary_10_3390_ijms17122144 crossref_primary_10_1038_s44318_024_00155_9 crossref_primary_10_1038_s41467_022_34067_1 crossref_primary_10_1111_cas_12816 crossref_primary_10_1016_j_snb_2018_01_132 crossref_primary_10_3390_biom13060912 crossref_primary_10_1016_j_cub_2015_12_064 crossref_primary_10_3390_ijms22083918 crossref_primary_10_1111_febs_17028 crossref_primary_10_1038_srep20229 crossref_primary_10_1371_journal_pbio_3003088 crossref_primary_10_1016_j_ccr_2020_213712 crossref_primary_10_1098_rsob_140171 crossref_primary_10_1038_s41586_023_06627_y crossref_primary_10_1016_j_devcel_2024_12_006 crossref_primary_10_1038_cddis_2016_80 crossref_primary_10_1038_s41419_022_05308_4 crossref_primary_10_1080_15384101_2015_1100776 crossref_primary_10_1242_dev_132340 crossref_primary_10_1038_s41467_021_25940_6 crossref_primary_10_1038_s41467_018_07114_z crossref_primary_10_3390_molecules25225477 crossref_primary_10_1093_jb_mvab034 crossref_primary_10_1038_onc_2017_68 crossref_primary_10_1038_s41467_024_49786_w crossref_primary_10_1016_j_imlet_2015_12_005 crossref_primary_10_1002_1873_3468_14822 crossref_primary_10_1007_s12192_019_01009_8 crossref_primary_10_1093_genetics_iyae107 crossref_primary_10_1242_bio_053405 crossref_primary_10_1002_1873_3468_14716 crossref_primary_10_1155_2018_4258387 crossref_primary_10_15252_embr_202255903 crossref_primary_10_1038_s42003_019_0541_0 crossref_primary_10_3390_biomedicines7040082 crossref_primary_10_1038_s41467_020_16070_6 crossref_primary_10_1371_journal_pbio_3000545 crossref_primary_10_1371_journal_pgen_1007187 crossref_primary_10_1242_dev_198705 crossref_primary_10_1038_s41419_019_1862_0 crossref_primary_10_3389_fimmu_2022_905370 crossref_primary_10_1016_j_semcdb_2022_04_002 crossref_primary_10_1007_s00018_024_05560_1 crossref_primary_10_1016_j_jmb_2018_06_002 crossref_primary_10_1002_dvdy_102 crossref_primary_10_7554_eLife_64919 crossref_primary_10_1038_s41556_022_00858_3 crossref_primary_10_3390_ijms231911244 crossref_primary_10_1016_j_ceb_2025_102545 crossref_primary_10_1038_nature20815 crossref_primary_10_1083_jcb_201805071 crossref_primary_10_1242_bio_059968 crossref_primary_10_1016_j_aca_2020_08_033 crossref_primary_10_1111_cas_14575 crossref_primary_10_26508_lsa_202101079 crossref_primary_10_1038_s41419_023_06170_8 crossref_primary_10_1371_journal_pgen_1007724 crossref_primary_10_1038_s41598_022_23780_y
Cites_doi	10.1038/ncb1052 10.1126/science.1088474 10.1074/jbc.C200324200 10.1126/science.1090289 10.1016/j.devcel.2007.07.012 10.1016/j.devcel.2008.01.006 10.1083/jcb.200702054 10.1038/cdd.2008.115 10.1093/emboj/cdf306 10.1016/S0960-9822(02)00954-5 10.1534/genetics.105.045534 10.1101/gad.12.4.557 10.1016/j.ejcb.2007.11.002 10.1126/science.1216689 10.1038/cr.2009.16 10.1038/nature720 10.1016/j.ydbio.2010.11.036 10.1038/nature01486 10.4161/cc.9.19.13280 10.1158/0008-5472.CAN-07-6814 10.1016/j.devcel.2010.05.014 10.1038/sj.emboj.7601401 10.1016/j.cub.2010.03.019 10.1038/ncb1324 10.1038/nature00888 10.1242/jcs.023648 10.1126/science.1123061 10.1073/pnas.1004279107 10.1242/jcs.01029 10.1101/gad.986602 10.1093/emboj/cdg548 10.1016/j.devcel.2009.01.002 10.1083/jcb.200311031
ContentType	Journal Article
Copyright	Springer Nature Limited 2015 Copyright Nature Publishing Group Jun 25, 2015 Attribution
Copyright_xml	– notice: Springer Nature Limited 2015 – notice: Copyright Nature Publishing Group Jun 25, 2015 – notice: Attribution
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QG 7QL 7QP 7QR 7RV 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7X2 7X7 7XB 88A 88E 88G 88I 8AF 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK 8G5 ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BEC BENPR BGLVJ BHPHI BKSAR C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M2M M2O M2P M7N M7P M7S MBDVC NAPCQ P5Z P62 P64 PATMY PCBAR PDBOC PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ PTHSS PYCSY Q9U R05 RC3 S0X SOI 7X8 1XC VOOES
DOI	10.1038/nature14298
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Meteorological & Geoastrophysical Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Psychology Database (Alumni) Science Database (Alumni Edition) STEM Database ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection eLibrary ProQuest Central Technology collection Natural Science Collection Earth, Atmospheric & Aquatic Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database ProQuest Health & Medical Collection Medical Database Psychology Database Research Library Science Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Research Library (Corporate) Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Earth, Atmospheric & Aquatic Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology Engineering Collection Environmental Science Collection ProQuest Central Basic University of Michigan Genetics Abstracts SIRS Editorial Environment Abstracts MEDLINE - Academic Hyper Article en Ligne (HAL) Hyper Article en Ligne (HAL) (Open Access)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database ProQuest One Psychology Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts elibrary ProQuest AP Science SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Earth, Atmospheric & Aquatic Science Database Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) University of Michigan Technology Collection Technology Research Database ProQuest One Academic Middle East (New) SIRS Editorial Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Earth, Atmospheric & Aquatic Science Collection ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Research Library ProQuest Materials Science Collection ProQuest Public Health ProQuest Central Basic ProQuest Science Journals ProQuest Nursing & Allied Health Source ProQuest Psychology Journals (Alumni) ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library ProQuest Psychology Journals Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE Agricultural Science Database MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: PATMY name: Environmental Science Database url: http://search.proquest.com/environmentalscience sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Sciences (General) Physics
EISSN	1476-4687
EndPage	486
ExternalDocumentID	oai:HAL:hal-01255294v1 3729584441 25874673 10_1038_nature14298
Genre	Research Support, Non-U.S. Gov't Journal Article
GroupedDBID	--- --Z -DZ -ET -~X .55 .CO .XZ 00M 07C 0R~ 0WA 123 186 1OL 1VR 29M 2KS 2XV 39C 3V. 4.4 41X 53G 5RE 6TJ 70F 7RV 7X2 7X7 7XC 85S 88A 88E 88I 8AF 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ 8G5 8R4 8R5 8WZ 97F 97L A6W A7Z A8Z AAEEF AAHBH AAHTB AAIKC AAKAB AAKAS AAMNW AASDW AAYEP AAYZH AAZLF ABAWZ ABDBF ABDQB ABFSI ABIVO ABJCF ABJNI ABLJU ABOCM ABPEJ ABPPZ ABUWG ABWJO ABZEH ACBEA ACBWK ACGFO ACGFS ACGOD ACIWK ACKOT ACMJI ACNCT ACPRK ACUHS ACWUS ADBBV ADFRT ADUKH ADYSU ADZCM AENEX AEUYN AFFDN AFFNX AFKRA AFLOW AFRAH AFSHS AGAYW AGHSJ AGHTU AGNAY AGSOS AHMBA AHSBF AIDAL AIDUJ ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH APEBS ARAPS ARMCB ARTTT ASPBG ATCPS ATWCN AVWKF AXYYD AZFZN AZQEC B0M BBNVY BCU BDKGC BEC BENPR BGLVJ BHPHI BIN BKEYQ BKKNO BKSAR BLC BPHCQ BVXVI CCPQU CJ0 CS3 D1I D1J D1K DO4 DU5 DWQXO E.- E.L EAD EAP EAS EAZ EBC EBD EBO EBS ECC EE. EJD EMB EMF EMH EMK EMOBN EPL EPS ESE ESN ESX EX3 EXGXG F5P FEDTE FQGFK FSGXE FYUFA GNUQQ GUQSH HCIFZ HG6 HMCUK HVGLF HZ~ I-F IAO ICQ IEA IEP IGS IH2 IHR INH INR IOF IPY ISR ITC K6- KB. KOO L6V L7B LK5 LK8 LSO M0K M0L M1P M2M M2O M2P M7P M7R M7S N9A NAPCQ NEJ NEPJS O9- OBC OES OHH OMK OVD P-O P2P P62 PATMY PCBAR PDBOC PKN PM3 PQQKQ PROAC PSQYO PSYQQ PTHSS PYCSY Q2X R05 RND RNS RNT RNTTT RXW S0X SC5 SHXYY SIXXV SJFOW SJN SNYQT SOJ SV3 TAE TAOOD TBHMF TDRGL TEORI TH9 TN5 TSG TUS TWZ U5U UIG UKHRP UKR UMD UQL VQA VVN WH7 WOW X7M XIH XKW XZL Y6R YAE YCJ YFH YIF YIN YNT YOC YQT YR2 YR5 YXB YZZ Z5M ZCA ZE2 ZKB ~02 ~7V ~88 ~8M ~KM AARCD AAYXX ABFSG ABUFD ACSTC ADXHL AETEA AFANA AFFHD ALPWD ATHPR CITATION PHGZM PHGZT PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NPM 7QG 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7XB 8FD 8FK C1K FR3 H94 K9. KL. M7N MBDVC P64 PKEHL PQEST PQUKI PRINS Q9U RC3 SOI 7X8 ADGHP ESTFP PUEGO .-4 .GJ .HR 08P 1CY 1VW 1XC 354 3EH 3O- 41~ 42X 4R4 663 79B 9M8 AAJYS AAVBQ ABDPE ABEFU ABNNU ACBNA ACBTR ACRPL ACTDY ADNMO ADRHT AEZWR AFBBN AFHIU AFHKK AFKWF AGCDD AGGDT AGQPQ AGSTI AHWEU AIXLP AIYXT AJUXI BCR BES BKOMP DB5 FA8 FAC J5H L-9 LGEZI LOTEE MVM N4W NADUK NFIDA NXXTH ODYON OHT PEA PV9 QS- R4F RHI SKT TUD UBY UHB USG VOH VOOES X7L XOL YJ6 YQI YQJ YV5 YXA YYP YYQ ZCG ZGI ZHY ZY4 ~G0
ID	FETCH-LOGICAL-c491t-db1379ff4f6882d352760c49a7002f37b9efac8715debdae17a65ab7bb19af793
IEDL.DBID	M2M
ISICitedReferencesCount	137
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000356782900051&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0028-0836 1476-4687
IngestDate	Tue Oct 14 20:41:56 EDT 2025 Thu Oct 02 19:13:55 EDT 2025 Sat Nov 29 14:33:25 EST 2025 Thu Apr 03 07:02:35 EDT 2025 Tue Nov 18 22:53:27 EST 2025 Sat Nov 29 05:17:50 EST 2025 Fri Feb 21 02:37:35 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	7557
Language	English
License	Attribution: http://creativecommons.org/licenses/by
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c491t-db1379ff4f6882d352760c49a7002f37b9efac8715debdae17a65ab7bb19af793
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
OpenAccessLink	https://hal.science/hal-01255294
PMID	25874673
PQID	1691990105
PQPubID	40569
PageCount	5
ParticipantIDs	hal_primary_oai_HAL_hal_01255294v1 proquest_miscellaneous_1691600428 proquest_journals_1691990105 pubmed_primary_25874673 crossref_primary_10_1038_nature14298 crossref_citationtrail_10_1038_nature14298 springer_journals_10_1038_nature14298
PublicationCentury	2000
PublicationDate	2015-06-25
PublicationDateYYYYMMDD	2015-06-25
PublicationDate_xml	– month: 06 year: 2015 text: 2015-06-25 day: 25
PublicationDecade	2010
PublicationPlace	London
PublicationPlace_xml	– name: London – name: England
PublicationSubtitle	International weekly journal of science
PublicationTitle	Nature (London)
PublicationTitleAbbrev	Nature
PublicationTitleAlternate	Nature
PublicationYear	2015
Publisher	Nature Publishing Group UK Nature Publishing Group
Publisher_xml	– name: Nature Publishing Group UK – name: Nature Publishing Group
References	Rong (CR31) 2002; 16 Moreno, Yan, Basler (CR7) 2002; 12 Robinson, Huang, Hong, Moberg (CR18) 2010; 20 Brumby, Richardson (CR11) 2003; 22 Geuking, Narasimamurthy, Basler (CR27) 2005; 171 Colombani, Andersen, Leopold (CR1) 2012; 336 Bulgakova, Knust (CR19) 2009; 122 Narasimamurthy (CR10) 2009; 19 Cordero (CR13) 2010; 18 Igaki (CR6) 2002; 21 Sotillos, Diaz-Meco, Caminero, Moscat, Campuzano (CR24) 2004; 166 Ling (CR17) 2010; 107 Xue (CR8) 2007; 13 Pagliarini, Xu (CR14) 2003; 302 Zhang (CR29) 2008; 14 Chakrabandhu (CR3) 2008; 15 Giot (CR23) 2003; 302 Betschinger, Mechtler, Knoblich (CR26) 2003; 422 Lu, Bilder (CR2) 2005; 7 Ye (CR4) 2002; 418 Martín-Blanco (CR30) 1998; 12 Ruel, Rodriguez, Gallet, Lavenant-Staccini, Therond (CR32) 2003; 5 Kanda, Igaki, Kanuka, Yagi, Miura (CR9) 2002; 277 Izaddoost, Nam, Bhat, Bellen, Choi (CR28) 2002; 416 Vidal (CR5) 2010; 9 Ciccarelli (CR33) 2006; 311 Uhlirova, Bohmann (CR15) 2006; 25 Bachmann, Grawe, Johnson, Knust (CR20) 2008; 87 Igaki, Pastor-Pareja, Aonuma, Miura, Xu (CR12) 2009; 16 Karp (CR25) 2008; 68 Olsen (CR22) 2007; 179 Sun, Irvine (CR16) 2011; 350 Bachmann (CR21) 2004; 117 S Sotillos (BFnature14298_CR24) 2004; 166 L Ruel (BFnature14298_CR32) 2003; 5 G Sun (BFnature14298_CR16) 2011; 350 FD Ciccarelli (BFnature14298_CR33) 2006; 311 E Martín-Blanco (BFnature14298_CR30) 1998; 12 H Lu (BFnature14298_CR2) 2005; 7 JB Cordero (BFnature14298_CR13) 2010; 18 A Bachmann (BFnature14298_CR21) 2004; 117 L Zhang (BFnature14298_CR29) 2008; 14 RA Pagliarini (BFnature14298_CR14) 2003; 302 CM Karp (BFnature14298_CR25) 2008; 68 M Uhlirova (BFnature14298_CR15) 2006; 25 L Xue (BFnature14298_CR8) 2007; 13 J Colombani (BFnature14298_CR1) 2012; 336 K Chakrabandhu (BFnature14298_CR3) 2008; 15 H Kanda (BFnature14298_CR9) 2002; 277 H Ye (BFnature14298_CR4) 2002; 418 T Igaki (BFnature14298_CR12) 2009; 16 NA Bulgakova (BFnature14298_CR19) 2009; 122 AM Brumby (BFnature14298_CR11) 2003; 22 C Ling (BFnature14298_CR17) 2010; 107 YS Rong (BFnature14298_CR31) 2002; 16 E Moreno (BFnature14298_CR7) 2002; 12 L Giot (BFnature14298_CR23) 2003; 302 BS Robinson (BFnature14298_CR18) 2010; 20 S Izaddoost (BFnature14298_CR28) 2002; 416 M Vidal (BFnature14298_CR5) 2010; 9 A Bachmann (BFnature14298_CR20) 2008; 87 R Narasimamurthy (BFnature14298_CR10) 2009; 19 O Olsen (BFnature14298_CR22) 2007; 179 J Betschinger (BFnature14298_CR26) 2003; 422 P Geuking (BFnature14298_CR27) 2005; 171 T Igaki (BFnature14298_CR6) 2002; 21
References_xml	– volume: 5 start-page: 907 year: 2003 end-page: 913 ident: CR32 article-title: Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog publication-title: Nature Cell Biol. doi: 10.1038/ncb1052 – volume: 302 start-page: 1227 year: 2003 end-page: 1231 ident: CR14 article-title: A genetic screen in for metastatic behavior publication-title: Science doi: 10.1126/science.1088474 – volume: 277 start-page: 28372 year: 2002 end-page: 28375 ident: CR9 article-title: Wengen, a member of the tumor necrosis factor receptor superfamily, is required for Eiger signaling publication-title: J. Biol. Chem. doi: 10.1074/jbc.C200324200 – volume: 302 start-page: 1727 year: 2003 end-page: 1736 ident: CR23 article-title: A protein interaction map of publication-title: Science doi: 10.1126/science.1090289 – volume: 13 start-page: 446 year: 2007 end-page: 454 ident: CR8 article-title: Tumor suppressor CYLD regulates JNK-induced cell death in publication-title: Dev. Cell doi: 10.1016/j.devcel.2007.07.012 – volume: 14 start-page: 377 year: 2008 end-page: 387 ident: CR29 article-title: The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control publication-title: Dev. Cell doi: 10.1016/j.devcel.2008.01.006 – volume: 179 start-page: 151 year: 2007 end-page: 164 ident: CR22 article-title: Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice publication-title: J. Cell Biol. doi: 10.1083/jcb.200702054 – volume: 15 start-page: 1824 year: 2008 end-page: 1837 ident: CR3 article-title: The extracellular glycosphingolipid-binding motif of Fas defines its internalization route, mode and outcome of signals upon activation by ligand publication-title: Cell Death Differ. doi: 10.1038/cdd.2008.115 – volume: 21 start-page: 3009 year: 2002 end-page: 3018 ident: CR6 article-title: Eiger, a TNF superfamily ligand that triggers the JNK pathway publication-title: EMBO J. doi: 10.1093/emboj/cdf306 – volume: 12 start-page: 1263 year: 2002 end-page: 1268 ident: CR7 article-title: Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the homolog of the TNF superfamily publication-title: Curr. Biol. doi: 10.1016/S0960-9822(02)00954-5 – volume: 171 start-page: 1683 year: 2005 end-page: 1694 ident: CR27 article-title: A genetic screen targeting the tumor necrosis factor/Eiger signaling pathway: identification of TAB2 as a functionally conserved component publication-title: Genetics doi: 10.1534/genetics.105.045534 – volume: 12 start-page: 557 year: 1998 end-page: 570 ident: CR30 article-title: encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in publication-title: Genes Dev. doi: 10.1101/gad.12.4.557 – volume: 87 start-page: 123 year: 2008 end-page: 136 ident: CR20 article-title: Lin-7 is a component of the Crumbs complex in epithelia and photoreceptor cells and prevents light-induced retinal degeneration publication-title: Eur. J. Cell Biol. doi: 10.1016/j.ejcb.2007.11.002 – volume: 336 start-page: 582 year: 2012 end-page: 585 ident: CR1 article-title: Secreted peptide Dilp8 coordinates tissue growth with developmental timing publication-title: Science doi: 10.1126/science.1216689 – volume: 19 start-page: 392 year: 2009 end-page: 394 ident: CR10 article-title: Structure–function analysis of Eiger, the TNF homolog publication-title: Cell Res. doi: 10.1038/cr.2009.16 – volume: 416 start-page: 178 year: 2002 end-page: 183 ident: CR28 article-title: Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres publication-title: Nature doi: 10.1038/nature720 – volume: 350 start-page: 139 year: 2011 end-page: 151 ident: CR16 article-title: Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2010.11.036 – volume: 422 start-page: 326 year: 2003 end-page: 330 ident: CR26 article-title: The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl publication-title: Nature doi: 10.1038/nature01486 – volume: 9 start-page: 3851 year: 2010 end-page: 3856 ident: CR5 article-title: The dark side of fly TNF: an ancient developmental proof reading mechanism turned into tumor promoter publication-title: Cell Cycle doi: 10.4161/cc.9.19.13280 – volume: 68 start-page: 4105 year: 2008 end-page: 4115 ident: CR25 article-title: Role of the polarity determinant crumbs in suppressing mammalian epithelial tumor progression publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-07-6814 – volume: 18 start-page: 999 year: 2010 end-page: 1011 ident: CR13 article-title: Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter publication-title: Dev. Cell doi: 10.1016/j.devcel.2010.05.014 – volume: 25 start-page: 5294 year: 2006 end-page: 5304 ident: CR15 article-title: JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in publication-title: EMBO J. doi: 10.1038/sj.emboj.7601401 – volume: 20 start-page: 582 year: 2010 end-page: 590 ident: CR18 article-title: Crumbs regulates Salvador/Warts/Hippo signaling in via the FERM-domain protein Expanded publication-title: Curr. Biol. doi: 10.1016/j.cub.2010.03.019 – volume: 7 start-page: 1232 year: 2005 end-page: 1239 ident: CR2 article-title: Endocytic control of epithelial polarity and proliferation in publication-title: Nature Cell Biol. doi: 10.1038/ncb1324 – volume: 418 start-page: 443 year: 2002 end-page: 447 ident: CR4 article-title: Distinct molecular mechanism for initiating TRAF6 signalling publication-title: Nature doi: 10.1038/nature00888 – volume: 122 start-page: 2587 year: 2009 end-page: 2596 ident: CR19 article-title: The Crumbs complex: from epithelial-cell polarity to retinal degeneration publication-title: J. Cell Sci. doi: 10.1242/jcs.023648 – volume: 311 start-page: 1283 year: 2006 end-page: 1287 ident: CR33 article-title: Toward automatic reconstruction of a highly resolved tree of life publication-title: Science doi: 10.1126/science.1123061 – volume: 107 start-page: 10532 year: 2010 end-page: 10537 ident: CR17 article-title: The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1004279107 – volume: 117 start-page: 1899 year: 2004 end-page: 1909 ident: CR21 article-title: Cell type-specific recruitment of Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97 publication-title: J. Cell Sci. doi: 10.1242/jcs.01029 – volume: 16 start-page: 1568 year: 2002 end-page: 1581 ident: CR31 article-title: Targeted mutagenesis by homologous recombination in publication-title: Genes Dev. doi: 10.1101/gad.986602 – volume: 22 start-page: 5769 year: 2003 end-page: 5779 ident: CR11 article-title: mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in publication-title: EMBO J. doi: 10.1093/emboj/cdg548 – volume: 16 start-page: 458 year: 2009 end-page: 465 ident: CR12 article-title: Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in publication-title: Dev. Cell doi: 10.1016/j.devcel.2009.01.002 – volume: 166 start-page: 549 year: 2004 end-page: 557 ident: CR24 article-title: DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in publication-title: J. Cell Biol. doi: 10.1083/jcb.200311031 – volume: 122 start-page: 2587 year: 2009 ident: BFnature14298_CR19 publication-title: J. Cell Sci. doi: 10.1242/jcs.023648 – volume: 166 start-page: 549 year: 2004 ident: BFnature14298_CR24 publication-title: J. Cell Biol. doi: 10.1083/jcb.200311031 – volume: 16 start-page: 1568 year: 2002 ident: BFnature14298_CR31 publication-title: Genes Dev. doi: 10.1101/gad.986602 – volume: 87 start-page: 123 year: 2008 ident: BFnature14298_CR20 publication-title: Eur. J. Cell Biol. doi: 10.1016/j.ejcb.2007.11.002 – volume: 18 start-page: 999 year: 2010 ident: BFnature14298_CR13 publication-title: Dev. Cell doi: 10.1016/j.devcel.2010.05.014 – volume: 9 start-page: 3851 year: 2010 ident: BFnature14298_CR5 publication-title: Cell Cycle doi: 10.4161/cc.9.19.13280 – volume: 179 start-page: 151 year: 2007 ident: BFnature14298_CR22 publication-title: J. Cell Biol. doi: 10.1083/jcb.200702054 – volume: 418 start-page: 443 year: 2002 ident: BFnature14298_CR4 publication-title: Nature doi: 10.1038/nature00888 – volume: 422 start-page: 326 year: 2003 ident: BFnature14298_CR26 publication-title: Nature doi: 10.1038/nature01486 – volume: 171 start-page: 1683 year: 2005 ident: BFnature14298_CR27 publication-title: Genetics doi: 10.1534/genetics.105.045534 – volume: 416 start-page: 178 year: 2002 ident: BFnature14298_CR28 publication-title: Nature doi: 10.1038/nature720 – volume: 22 start-page: 5769 year: 2003 ident: BFnature14298_CR11 publication-title: EMBO J. doi: 10.1093/emboj/cdg548 – volume: 7 start-page: 1232 year: 2005 ident: BFnature14298_CR2 publication-title: Nature Cell Biol. doi: 10.1038/ncb1324 – volume: 302 start-page: 1227 year: 2003 ident: BFnature14298_CR14 publication-title: Science doi: 10.1126/science.1088474 – volume: 15 start-page: 1824 year: 2008 ident: BFnature14298_CR3 publication-title: Cell Death Differ. doi: 10.1038/cdd.2008.115 – volume: 25 start-page: 5294 year: 2006 ident: BFnature14298_CR15 publication-title: EMBO J. doi: 10.1038/sj.emboj.7601401 – volume: 68 start-page: 4105 year: 2008 ident: BFnature14298_CR25 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-07-6814 – volume: 336 start-page: 582 year: 2012 ident: BFnature14298_CR1 publication-title: Science doi: 10.1126/science.1216689 – volume: 16 start-page: 458 year: 2009 ident: BFnature14298_CR12 publication-title: Dev. Cell doi: 10.1016/j.devcel.2009.01.002 – volume: 19 start-page: 392 year: 2009 ident: BFnature14298_CR10 publication-title: Cell Res. doi: 10.1038/cr.2009.16 – volume: 117 start-page: 1899 year: 2004 ident: BFnature14298_CR21 publication-title: J. Cell Sci. doi: 10.1242/jcs.01029 – volume: 21 start-page: 3009 year: 2002 ident: BFnature14298_CR6 publication-title: EMBO J. doi: 10.1093/emboj/cdf306 – volume: 13 start-page: 446 year: 2007 ident: BFnature14298_CR8 publication-title: Dev. Cell doi: 10.1016/j.devcel.2007.07.012 – volume: 277 start-page: 28372 year: 2002 ident: BFnature14298_CR9 publication-title: J. Biol. Chem. doi: 10.1074/jbc.C200324200 – volume: 12 start-page: 1263 year: 2002 ident: BFnature14298_CR7 publication-title: Curr. Biol. doi: 10.1016/S0960-9822(02)00954-5 – volume: 12 start-page: 557 year: 1998 ident: BFnature14298_CR30 publication-title: Genes Dev. doi: 10.1101/gad.12.4.557 – volume: 311 start-page: 1283 year: 2006 ident: BFnature14298_CR33 publication-title: Science doi: 10.1126/science.1123061 – volume: 302 start-page: 1727 year: 2003 ident: BFnature14298_CR23 publication-title: Science doi: 10.1126/science.1090289 – volume: 20 start-page: 582 year: 2010 ident: BFnature14298_CR18 publication-title: Curr. Biol. doi: 10.1016/j.cub.2010.03.019 – volume: 5 start-page: 907 year: 2003 ident: BFnature14298_CR32 publication-title: Nature Cell Biol. doi: 10.1038/ncb1052 – volume: 14 start-page: 377 year: 2008 ident: BFnature14298_CR29 publication-title: Dev. Cell doi: 10.1016/j.devcel.2008.01.006 – volume: 350 start-page: 139 year: 2011 ident: BFnature14298_CR16 publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2010.11.036 – volume: 107 start-page: 10532 year: 2010 ident: BFnature14298_CR17 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1004279107
SSID	ssj0005174
Score	2.5363991
Snippet	Cell polarity is an important feature of many tissues and is often disrupted in cancer; the TNF receptor Grindelwald is now shown to have an important role in... Disruption of epithelial polarity is a key event in the acquisition of neoplastic growth. JNK signalling is known to play an important part in driving the...
SourceID	hal proquest pubmed crossref springer
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	482
SubjectTerms	631/80/304 Amino Acid Sequence Animals Apoptosis Apoptosis - genetics Biochemistry, Molecular Biology Cancer Cell Adhesion Molecules Cell Adhesion Molecules - metabolism Cell Division Cell Division - genetics Cell Polarity Cell Polarity - genetics Cell Transformation, Neoplastic Cell Transformation, Neoplastic - genetics Cloning Development Biology Disease Models, Animal Drosophila melanogaster Drosophila melanogaster - cytology Drosophila melanogaster - enzymology Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins Drosophila Proteins - chemistry Drosophila Proteins - deficiency Drosophila Proteins - genetics Drosophila Proteins - metabolism Female Genes Genomics Genotype & phenotype Humanities and Social Sciences Humans Insects JNK Mitogen-Activated Protein Kinases JNK Mitogen-Activated Protein Kinases - metabolism letter Life Sciences Male MAP Kinase Signaling System Matrix Metalloproteinase 1 Matrix Metalloproteinase 1 - metabolism Membrane Proteins Membrane Proteins - chemistry Membrane Proteins - deficiency Membrane Proteins - genetics Membrane Proteins - metabolism Molecular Sequence Data multidisciplinary Neoplasm Invasiveness Neoplasm Invasiveness - genetics Neoplasms Neoplasms - enzymology Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Proteins ras Proteins ras Proteins - genetics ras Proteins - metabolism Receptors, Tumor Necrosis Factor Receptors, Tumor Necrosis Factor - chemistry Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor - metabolism Science Tumors
Title	The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth
URI	https://link.springer.com/article/10.1038/nature14298 https://www.ncbi.nlm.nih.gov/pubmed/25874673 https://www.proquest.com/docview/1691990105 https://www.proquest.com/docview/1691600428 https://hal.science/hal-01255294
Volume	522
WOSCitedRecordID	wos000356782900051&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAQT databaseName: Nature customDbUrl: eissn: 1476-4687 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: RNT dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.nature.com providerName: Nature Publishing – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1476-4687 dateEnd: 20241209 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: P5Z dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agricultural Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241209 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M0K dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241209 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M7P dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Earth, Atmospheric & Aquatic Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241209 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: PCBAR dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/eaasdb providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1476-4687 dateEnd: 20241209 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M7S dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241209 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: PATMY dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1476-4687 dateEnd: 20241209 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: 7X7 dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241209 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: KB. dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1476-4687 dateEnd: 20241209 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: 7RV dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1476-4687 dateEnd: 20241209 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: BENPR dateStart: 19880107 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Psychology Database customDbUrl: eissn: 1476-4687 dateEnd: 20241209 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M2M dateStart: 19880107 isFulltext: true titleUrlDefault: https://www.proquest.com/psychology providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1476-4687 dateEnd: 20241209 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: 8C1 dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Research Library customDbUrl: eissn: 1476-4687 dateEnd: 20241209 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M2O dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241209 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M2P dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwED_RDSRegI2vwKgMGhIghTUfju0ntI2VSVtLNbapgofIdhI2KWpDP8a_z52TdoMiXng5KY3Tur4P3_kuvwPYzrKIi8xIP4pN5sdGWF_FKqQkbx4k2ljuzjvOj0W_L4dDNWgO3KZNWeXCJjpDnY0tnZHvEKgL5XA6_EP1w6euUZRdbVpotGAdHWVJitkLe9clHn-gMDfv53UiuVPDZgZojeVvO1LrguohV53NlUSp23-69_935g_gXuN5st1aVDbgVj7ahDuuAtRON2Gj0fIpe9NAUb99CN9QitjHiet1cFlqdtrvMjSReYWROvs0IajF8qcuM2bH86rEZ0v8h2xcMMoHsIrCZvTymR5lbESl6ppQodl3DP1nF4_grHtwun_oN-0YfBurYOZnJoiEKoq4SNAtRx6HIungLS1wgYtIGJUX2mIAxrPcZDoPhE64NsKYQOkC7cBjWBuNR_lTYHQSzZVF30AlsTVWSSOt0AE-z1FUYg_eLViS2garnFpmlKnLmUcyvcE_D7aXg6saouPvw14hb5cjCFb7cPc4pc9wk-Y8VPFV4MHWgodpo8zT9JqBHrxc3kY1pLXUuHzzekziAlAPntQis_ypkEtq6hJ58HohQze-fHWmz_49iedwF702TvVqId-Ctdlknr-A2_ZqdjmdtKElTs6JDoWjEqncD9qwvnfQH5zg1dHee6S9zlHbaYujnx0dEBU1_YJ0wL_-ArN_Gpc
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VAoIL0PIKFDColQAp6ubhOD4gVFGWrbosHBZUiUOwnYRWipKQ7HbFn-I3MpPHtrCIWw9cEztxnM_jefkbgO049riIdWh7vo5tXwtjS1-6FORNnEBpwxt_x-exmEzCoyP5cQ1-9mdhKK2yl4mNoI4LQz7yXSJ1oRjOgL8uv9tUNYqiq30JjRYWh8mPBZps9auDffy_O647fDt9M7K7qgK28aUzs2PteEKmqZ8GqF3iUF0RDPCWEigcUk9omaTKoB3B40THKnGECrjSQmtHqlQQ-RKK_Ms-WUKUKuh-OEsp-YP1uTsPOPDC3Zam00HpH_62A146pvzLVeV2JTDb7HfDm__bTN2CG51mzfbapbABa0m-CVebDFdTb8JGJ8Vq9ryj2n5xG77gKmH7VVPL4SRTbDoZMtwCknJWVOxdRVSS2UJlMTPFvMywb4YzyoqUUbyDleQWQCuGqTxmOaXiK2K9Zt-qYjE7vgOfLuRz78J6XuTJfWDkaefSoO4jA99oI0MdGqEc7M9xKfgWvOwhEJmOi51KgmRRkxPghdE5vFiwvWxcthQkf2_2DLG0bEG04aO9cUTXUAnh3JX-qWPBVo-ZqBNWdXQGGAueLm-jmKG5VDh987ZN0BjYFtxrIbp8lctDKlrjWbDTY_bcw1dH-uDfg3gC10bT9-NofDA5fAjXUUPllJvn8i1Yn1Xz5BFcMaezk7p63Kw-Bl8vGsS_ADOIbU0
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6V8hAXoIVCoIBBrQSVot08HMcHhCqWpVVXqz0UVMEh2E5CK0VJyO52xV_j1zGTx7awiFsPXBMncZzP4xnPl28AduLY4yLWoe35OrZ9LYwtfelSkjdxAqUNr_c7Po3EeByenMjJGvzs_oUhWmVnE2tDHReG9sh7JOpCOZw-76UtLWIyGL4tv9tUQYoyrV05jQYiR8mPBYZv0zeHA_zWu647fH_87sBuKwzYxpfOzI614wmZpn4aoKeJ3XZF0MdTSqChSD2hZZIqgzEFjxMdq8QRKuBKC60dqVJBQkxo_q8LjDGJTjjhny_oJX8oQLf_Bva9sNdIdjq4EoS_rYbXTomLueroriRp67VvePd_HrV7cKf1uNl-M0U2YC3JN-FmzXw1003YaK3blL1qJbhf34cvOHvYoKprPJxlih2PhwyXhqScFRX7UJHEZLZQWcxMMS8zvDbD0WVFyigPwkraLsDohqk8ZjlR9BWpYbNvVbGYnT6Aj1fyuluwnhd58ggY7cBzadAnkoFvtJGhDo1QDl7PcYr4Fux1cIhMq9FOpUKyqOYKeGF0CTsW7Cwbl400yd-bvURcLVuQnPjB_iiiY-iccO5K_9yxYLvDT9QasWl0AR4LXixPo_mhsVQ4fPOmTVAH3hY8bOC6fJTLQypm41mw2-H30s1Xe_r43514DrcQu9HocHz0BG6j48qJsufybVifVfPkKdww57OzafWsnogMvl41hn8BS8J2PA
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Drosophila+TNF+receptor+Grindelwald+couples+loss+of+cell+polarity+and+neoplastic+growth&rft.jtitle=Nature+%28London%29&rft.au=Andersen%2C+Ditte+S.&rft.au=Colombani%2C+Julien&rft.au=Palmerini%2C+Valentina&rft.au=Chakrabandhu%2C+Krittalak&rft.date=2015-06-25&rft.issn=0028-0836&rft.eissn=1476-4687&rft.volume=522&rft.issue=7557&rft.spage=482&rft.epage=486&rft_id=info:doi/10.1038%2Fnature14298&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_nature14298
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-0836&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-0836&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-0836&client=summon