Noninvasive prenatal detection and selective analysis of cell-free DNA obtained from maternal blood: evaluation for trisomy 21 and trisomy 18

We sought to develop a novel biochemical assay and algorithm for the prenatal evaluation of risk for fetal trisomy 21 (T21) and trisomy 18 (T18) using cell-free DNA obtained from maternal blood. We assayed cell-free DNA from a training set and a blinded validation set of pregnant women, comprising 2...

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Veröffentlicht in:	American journal of obstetrics and gynecology Jg. 206; H. 4; S. 319.e1 - 319.e9
Hauptverfasser:	Sparks, Andrew B., Struble, Craig A., Wang, Eric T., Song, Ken, Oliphant, Arnold
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York, NY Mosby, Inc 01.04.2012 Elsevier
Schlagworte:	Adult aneuploidy detection Biological and medical sciences Case-Control Studies Chromosome aberrations Chromosomes, Human, Pair 18 - genetics DNA - blood DNA - genetics Down syndrome Down Syndrome - diagnosis Female Fetus Gynecology. Andrology. Obstetrics Humans Male Medical genetics Medical sciences noninvasive prenatal diagnostics Obstetrics and Gynecology Pregnancy Pregnancy Trimester, First - blood Prenatal Diagnosis - methods Risk Sensitivity and Specificity trisomy Trisomy - diagnosis aneuploidy detection noninvasive prenatal diagnostics Down syndrome trisomy Chromosomal aberration Trisomy Gynecology Aneuploidy Obstetrics Blood Chromosome E18 Prenatal diagnosis Mother DNA Cell Edwards syndrome
ISSN:	0002-9378, 1097-6868, 1097-6868
Online-Zugang:	Volltext
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