Multiple sclerosis and depression

Clinically significant depression can affect up to 50% of patients with multiple sclerosis over the course of their lifetime. It is associated with an increased morbidity and mortality and is regarded by patients as one of the main determinants of their quality of life. This review summarizes curren...

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Bibliographic Details
Published in:Multiple sclerosis Vol. 17; no. 11; pp. 1276 - 1281
Main Author: Feinstein, Anthony
Format: Journal Article
Language:English
Published: London, England SAGE Publications 01.11.2011
Sage Publications
Sage Publications Ltd
Subjects:
Affect
Biological and medical sciences
Cost of Illness
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Depression - diagnosis
Depression - epidemiology
Depression - psychology
Depression - therapy
Humans
Medical sciences
Multiple Sclerosis - diagnosis
Multiple Sclerosis - epidemiology
Multiple Sclerosis - psychology
Multiple Sclerosis - therapy
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Prevalence
Prognosis
Psychiatric Status Rating Scales
Quality of Life
Risk Factors
Suicide - prevention & control
Suicide - psychology
Surveys and Questionnaires
brain imaging
mortality
pathogenesis
treatment
diagnosis
depression
Mood disorder
Nervous system diseases
Multiple sclerosis
Pathogenesis
Mortality
Central nervous system
Depression
Inflammatory disease
Encephalon
Treatment
Central nervous system disease
Degenerative disease
Diagnosis
ISSN:1352-4585, 1477-0970, 1477-0970
Online Access:Get full text
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Description
Summary:Clinically significant depression can affect up to 50% of patients with multiple sclerosis over the course of their lifetime. It is associated with an increased morbidity and mortality and is regarded by patients as one of the main determinants of their quality of life. This review summarizes current perspectives relating to diagnosis, the utility of self report screening questionnaires, warning signs of suicidal intent and the biological and psychosocial variables implicated in mood change. In particular, the association between depression and structural brain abnormalities, including those derived from diffusion tensor imaging, is highlighted. Depression is treatable, as the results from randomized controlled trials of antidepressant medication, cognitive behavior therapy and mindfulness therapy, reveal. These positive findings are offset by data showing that depression in a neurological setting is often overlooked and under treated.
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ISSN:1352-4585
1477-0970
1477-0970
DOI:10.1177/1352458511417835