Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

Macrophages are a heterogeneous cell population involved in tissue homeostasis, inflammation, and various pathologies. Although the major tissue-resident macrophage populations have been extensively studied, interstitial macrophages (IMs) residing within the tissue parenchyma remain poorly defined....

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Science (American Association for the Advancement of Science) Ročník 363; číslo 6432
Hlavní autori: Chakarov, Svetoslav, Lim, Hwee Ying, Tan, Leonard, Lim, Sheau Yng, See, Peter, Lum, Josephine, Zhang, Xiao-Meng, Foo, Shihui, Nakamizo, Satoshi, Duan, Kaibo, Kong, Wan Ting, Gentek, Rebecca, Balachander, Akhila, Carbajo, Daniel, Bleriot, Camille, Malleret, Benoit, Tam, John Kit Chung, Baig, Sonia, Shabeer, Muhammad, Toh, Sue-Anne Ee Shiow, Schlitzer, Andreas, Larbi, Anis, Marichal, Thomas, Malissen, Bernard, Chen, Jinmiao, Poidinger, Michael, Kabashima, Kenji, Bajenoff, Marc, Ng, Lai Guan, Angeli, Veronique, Ginhoux, Florent
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 15.03.2019
Predmet:
Animals
Antigens, Ly
Cell Lineage
CX3C Chemokine Receptor 1 - genetics
Dermis - immunology
Disease Models, Animal
Fibrosis
Glycoproteins - analysis
Histocompatibility Antigens Class II - genetics
Lung - immunology
Lung - pathology
Macrophages - immunology
Mice
Mice, Inbred C57BL
Monocytes - immunology
Myocardium - immunology
Organic Anion Transporters - genetics
Sequence Analysis, RNA - methods
Single-Cell Analysis - methods
Transcriptome
ISSN:1095-9203, 1095-9203
On-line prístup:Zistit podrobnosti o prístupe
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:Macrophages are a heterogeneous cell population involved in tissue homeostasis, inflammation, and various pathologies. Although the major tissue-resident macrophage populations have been extensively studied, interstitial macrophages (IMs) residing within the tissue parenchyma remain poorly defined. Here we studied IMs from murine lung, fat, heart, and dermis. We identified two independent IM subpopulations that are conserved across tissues: Lyve1 MHCII CX3CR1 (Lyve1 MHCII ) and Lyve1 MHCII CX3CR1 (Lyve1 MHCII ) monocyte-derived IMs, with distinct gene expression profiles, phenotypes, functions, and localizations. Using a new mouse model of inducible macrophage depletion ( ), we found that the absence of Lyve1 MHCII IMs exacerbated experimental lung fibrosis. Thus, we demonstrate that two independent populations of IMs coexist across tissues and exhibit conserved niche-dependent functional programming.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1095-9203
1095-9203
DOI:10.1126/science.aau0964