Highly reactive anti-myelin oligodendrocyte glycoprotein antibodies differentiate demyelinating diseases from viral encephalitis in children

Background: Myelin oligodendrocyte glycoprotein (MOG) may be implicated in the immunopathogenesis of multiple sclerosis (MS) inducing demyelination in the animal model of MS. In adults reported anti-MOG antibody frequencies have been variable across a number of studies and can also be detected in co...

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Vydané v:	Multiple sclerosis Ročník 17; číslo 3; s. 297 - 302
Hlavní autori:	Lalive, PH, Häusler, MG, Maurey, H, Mikaeloff, Y, Tardieu, M, Wiendl, H, Schroeter, M, Hartung, HP, Kieseier, BC, Menge, T
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London, England SAGE Publications 01.03.2011 Sage Publications Sage Publications Ltd
Predmet:	Adolescent Autoantibodies - blood Biological and medical sciences Biomarkers - blood Chi-Square Distribution Child Child, Preschool Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Demyelinating Diseases - diagnosis Demyelinating Diseases - immunology Diagnosis, Differential Encephalitis, Viral - diagnosis Encephalitis, Viral - immunology Encephalomyelitis, Acute Disseminated - diagnosis Encephalomyelitis, Acute Disseminated - immunology Enzyme-Linked Immunosorbent Assay Epstein-Barr virus Epstein-Barr Virus Infections - diagnosis Epstein-Barr Virus Infections - immunology Female Flow Cytometry France Germany Humans Immunity, Humoral Male Medical sciences Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Myelin Basic Protein Myelin Proteins Myelin-Associated Glycoprotein - immunology Myelin-Oligodendrocyte Glycoprotein Nerve Tissue Proteins - immunology Neurology Predictive Value of Tests Retrospective Studies Transcription Factors - immunology France Germany acute disseminated encephalomyelitis paediatric multiple sclerosis myelin/oligodendrocyte glycoprotein autoantibodies Epstein–Barr virus antibody assays Autoimmunity Multiple sclerosis Encephalomyelitis Neuroglia Epstein Barr virus Epstein―Barr virus Inflammatory disease Oligodendrocyte Degenerative disease Child Gammaherpesvirinae Human Encephalitis Nervous system diseases Myelin Herpesviridae Glycoprotein Autoantibody Cerebral disorder Infection Virus Viral disease Central nervous system disease Spinal cord disease
ISSN:	1352-4585, 1477-0970, 1477-0970
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Shrnutí:	Background: Myelin oligodendrocyte glycoprotein (MOG) may be implicated in the immunopathogenesis of multiple sclerosis (MS) inducing demyelination in the animal model of MS. In adults reported anti-MOG antibody frequencies have been variable across a number of studies and can also be detected in controls. Objective: To measure antibodies against MOG in paediatric patients with demyelinating disorders of the central nervous system and in controls. Methods: Serum antibodies against MOG and myelin basic protein were measured by ELISA, flow cytometry (FACS) and in the liquid phase in 11 children with acute disseminated encephalomyelitis (ADEM), 22 children with MS, seven children with acute viral encephalitis and 13 healthy controls. The serostatus of Epstein–Barr virus (EBV) infections were assessed. Results: Anti-MOG antibodies, measured either by ELISA or FACS were exclusively detected in children with demyelination. In ADEM these antibodies were highly reactive. Anti-MBP reactivity was detectable equally in all groups. The presence of either autoantibodies did not associate with EBV serostatus, age, gender or disease course. Conclusions: This study independently corroborates recently published results of seroprevalence and specificity of the assay. Due to their low sensitivity anti-MOG antibodies will not serve as disease-specific biomarkers, but could help to support the diagnosis of ADEM in difficult cases.
Bibliografia:	SourceType-Scholarly Journals-1 ObjectType-General Information-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-3 ObjectType-Article-2 ObjectType-Feature-1 content type line 23
ISSN:	1352-4585 1477-0970 1477-0970
DOI:	10.1177/1352458510389220