Considering Photodynamic Therapy as a Therapeutic Modality in Selected Cases of Dome-Shaped Macula Complicated by Foveal Serous Retinal Detachment

BACKGROUND AND OBJECTIVE: To study the role of photodynamic therapy (PDT) as a therapeutic modality in myopic patients with dome-shaped macula (DSM) associated with foveal serous retinal detachment (SRD). PATIENTS AND METHODS: Retrospective interventional case series. The medical records of 10 conse...

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Published in:Ophthalmic surgery, lasers & imaging Vol. 46; no. 2; pp. 217 - 223
Main Authors: Arapi, Ilir, Neri, Piergiorgio, Mariotti, Cesare, Gesuita, Rosaria, Pirani, Vittorio, Freddo, Francesco, Lutaj, Pajtim, Giovannini, Alfonso
Format: Journal Article
Language:English
Published: United States SLACK INCORPORATED 01.02.2015
Subjects:
Adult
Aged
Coloring Agents
Dilatation, Pathologic
Eye diseases
Female
Fluorescein Angiography
Follow-Up Studies
Fovea Centralis - drug effects
Fovea Centralis - pathology
Humans
Indocyanine Green
Macula Lutea - drug effects
Macula Lutea - pathology
Male
Middle Aged
Myopia - complications
Photochemotherapy
Photodynamic therapy
Photosensitizing Agents - therapeutic use
Porphyrins - therapeutic use
Retinal Detachment - diagnosis
Retinal Detachment - drug therapy
Retinal Detachment - etiology
Retinal Diseases - complications
Retinal Diseases - diagnosis
Retinal Diseases - drug therapy
Retrospective Studies
Subretinal Fluid
Tomography, Optical Coherence
Visual Acuity - physiology
ISSN:2325-8160, 2325-8179, 2325-8179
Online Access:Get full text
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Summary:BACKGROUND AND OBJECTIVE: To study the role of photodynamic therapy (PDT) as a therapeutic modality in myopic patients with dome-shaped macula (DSM) associated with foveal serous retinal detachment (SRD). PATIENTS AND METHODS: Retrospective interventional case series. The medical records of 10 consecutive myopic patients (10 eyes) with DSM associated with subfoveal SRD and treated with PDT were reviewed. Visual gain and loss were considered as increasing or decreasing of two or more lines of best corrected visual acuity (BCVA), respectively, and eyes with fluid resolution were deemed responsive to PDT. RESULTS: All eyes underwent several PDT treatments, with a median of three and a median follow-up time of 15.5 months. At final follow-up, six eyes (60%) showed complete resolution of the foveal SRD. The baseline hypocyanescent macular area observed during late indocyanine green angiography (ICGA) frames was significantly lower in the group of patients who responded to PDT and had an increase of at least two Snellen lines in BCVA (All eyes underwent several PDT treatments, with a median of three and a median follow-up time of 15.5 months. At final follow-up, six eyes (60%) showed complete resolution of the foveal SRD. The baseline hypocyanescent macular area observed during late indocyanine green angiography (ICGA) frames was significantly lower in the group of patients who responded to PDT and had an increase of at least two Snellen lines in BCVA ( P = .01). CONCLUSION: Data suggest that myopic eyes associated with DSM and foveal SRD may be responsive to PDT, showing total resolution of fluid accumulation and positive BCVA changes if baseline ICGA findings show evidence of a limited hypocyanescent macular area. [[ Ophthalmic Surg Lasers Imaging Retina. 2015;46:217–223.]
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ISSN:2325-8160
2325-8179
2325-8179
DOI:10.3928/23258160-20150213-15