In vivo optical coherence tomography for the diagnosis of oral malignancy

Background and Objective Oral cancer results in 10,000 U.S. deaths annually. Improved highly sensitive diagnostics allowing early detection of oral cancer would benefit patient survival and quality of life. Objective was to investigate in vivo non‐invasive optical coherence tomography (OCT) techniqu...

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Vydáno v:	Lasers in surgery and medicine Ročník 35; číslo 4; s. 269 - 275
Hlavní autoři:	Wilder-Smith, Petra, Jung, Woong-Gyu, Brenner, Matthew, Osann, Kathryn, Beydoun, Hamza, Messadi, Diana, Chen, Zhongping
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.10.2004
Témata:	Animals carcinoma Carcinoma, Squamous Cell - pathology Cricetinae Equipment Design imaging leukoplakia Mouth Neoplasms - pathology non-invasive diagnostics oral diagnosis Tomography, Optical Coherence - instrumentation
ISSN:	0196-8092, 1096-9101
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Shrnutí:	Background and Objective Oral cancer results in 10,000 U.S. deaths annually. Improved highly sensitive diagnostics allowing early detection of oral cancer would benefit patient survival and quality of life. Objective was to investigate in vivo non‐invasive optical coherence tomography (OCT) techniques for imaging and diagnosing neoplasia‐related epithelial, sub‐epithelial changes throughout carcinogenesis. Study Design/Materials and Methods In the standard hamster cheek pouch model for oral carcinogenesis (n = 36), in vivo OCT was used to image epithelial and sub‐epithelial change. OCT‐ and histopathology‐based diagnoses on a scale of 0 (healthy) to 6 (squamous cell carcinoma, SCC) were performed at all stages throughout carcinogenesis by two blinded investigators. Results Epithelial, sub‐epithelial structures were clearly discernible using OCT. OCT diagnosis agreed with the histopathological gold standard in 80% of readings. Conclusion In vivo OCT demonstrates excellent potential as a diagnostic tool in the oral cavity. Lasers Surg. Med. 35:269–275, 2004. © 2004 Wiley‐Liss, Inc.
Bibliografie:	DOE - No. DE903-91ER 61227 Irvine Chao Family Comprehensive Cancer Center NIH - No. EB-00293 CA91717 ArticleID:LSM20098 CRFA - No. 30003 University of California istex:CA68A4A2711CD37269E0A6109700510FEC08916F CRFA - No. 27722 CCRP - No. 00-01391V-20235 TRDRP - No. 71T-0192 NIH - No. RO21 CA8752701 NIH (LAMMP) - No. RR01192 ark:/67375/WNG-8VLZ32TL-4 NSF - No. BES-86924; No. PMUSA-32598 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0196-8092 1096-9101
DOI:	10.1002/lsm.20098