In vivo optical coherence tomography for the diagnosis of oral malignancy

Background and Objective Oral cancer results in 10,000 U.S. deaths annually. Improved highly sensitive diagnostics allowing early detection of oral cancer would benefit patient survival and quality of life. Objective was to investigate in vivo non‐invasive optical coherence tomography (OCT) techniqu...

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Veröffentlicht in:Lasers in surgery and medicine Jg. 35; H. 4; S. 269 - 275
Hauptverfasser: Wilder-Smith, Petra, Jung, Woong-Gyu, Brenner, Matthew, Osann, Kathryn, Beydoun, Hamza, Messadi, Diana, Chen, Zhongping
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.10.2004
Schlagworte:
Animals
carcinoma
Carcinoma, Squamous Cell - pathology
Cricetinae
Equipment Design
imaging
leukoplakia
Mouth Neoplasms - pathology
non-invasive diagnostics
oral diagnosis
Tomography, Optical Coherence - instrumentation
ISSN:0196-8092, 1096-9101
Online-Zugang:Volltext
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Zusammenfassung:Background and Objective Oral cancer results in 10,000 U.S. deaths annually. Improved highly sensitive diagnostics allowing early detection of oral cancer would benefit patient survival and quality of life. Objective was to investigate in vivo non‐invasive optical coherence tomography (OCT) techniques for imaging and diagnosing neoplasia‐related epithelial, sub‐epithelial changes throughout carcinogenesis. Study Design/Materials and Methods In the standard hamster cheek pouch model for oral carcinogenesis (n = 36), in vivo OCT was used to image epithelial and sub‐epithelial change. OCT‐ and histopathology‐based diagnoses on a scale of 0 (healthy) to 6 (squamous cell carcinoma, SCC) were performed at all stages throughout carcinogenesis by two blinded investigators. Results Epithelial, sub‐epithelial structures were clearly discernible using OCT. OCT diagnosis agreed with the histopathological gold standard in 80% of readings. Conclusion In vivo OCT demonstrates excellent potential as a diagnostic tool in the oral cavity. Lasers Surg. Med. 35:269–275, 2004. © 2004 Wiley‐Liss, Inc.
Bibliographie:DOE - No. DE903-91ER 61227
Irvine Chao Family Comprehensive Cancer Center
NIH - No. EB-00293 CA91717
ArticleID:LSM20098
CRFA - No. 30003
University of California
istex:CA68A4A2711CD37269E0A6109700510FEC08916F
CRFA - No. 27722
CCRP - No. 00-01391V-20235
TRDRP - No. 71T-0192
NIH - No. RO21 CA8752701
NIH (LAMMP) - No. RR01192
ark:/67375/WNG-8VLZ32TL-4
NSF - No. BES-86924; No. PMUSA-32598
ObjectType-Article-2
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ObjectType-Feature-1
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ISSN:0196-8092
1096-9101
DOI:10.1002/lsm.20098