Colorectal cancer risk and nitrate exposure through drinking water and diet

Ingested nitrate leads to the endogenous synthesis of N‐nitroso compounds (NOCs), animal carcinogens with limited human evidence. We aimed to evaluate the risk of colorectal cancer (CRC) associated with nitrate exposure in drinking water and diet. A case‐control study in Spain and Italy during 2008‐...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:International journal of cancer Ročník 139; číslo 2; s. 334 - 346
Hlavní autoři: Espejo‐Herrera, Nadia, Gràcia‐Lavedan, Esther, Boldo, Elena, Aragonés, Nuria, Pérez‐Gómez, Beatriz, Pollán, Marina, Molina, Antonio J., Fernández, Tania, Martín, Vicente, La Vecchia, Carlo, Bosetti, Cristina, Tavani, Alessandra, Polesel, Jerry, Serraino, Diego, Gómez Acebo, Inés, Altzibar, Jone M., Ardanaz, Eva, Burgui, Rosana, Pisa, Federica, Fernández‐Tardón, Guillermo, Tardón, Adonina, Peiró, Rosana, Navarro, Carmen, Castaño‐Vinyals, Gemma, Moreno, Victor, Righi, Elena, Aggazzotti, Gabriella, Basagaña, Xavier, Nieuwenhuijsen, Mark, Kogevinas, Manolis, Villanueva, Cristina M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Wiley Subscription Services, Inc 15.07.2016
Wiley
Témata:
Adult
Age
Aged
Aged, 80 and over
Amides
Amines
Cancer
Carcinogens
Case-Control Studies
Colon cancer
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - etiology
Càncer
Diet
Diet - adverse effects
Dietary intake
Dose-response effects
Drinking water
Drinking Water - adverse effects
Environmental Exposure - adverse effects
Female
Food composition
Food intake
Gastrointestinal tract
Health risk assessment
Humans
Incidence
Inventories
Italy - epidemiology
Male
Meat
Medical research
Middle Aged
N-Nitroso compounds
Nitrate
Nitrates
Nitrates - adverse effects
Nitrats
Nitrosation
Population Surveillance
Recte
Rectum
Risk
Risk factors
Spain - epidemiology
Vegetables
Young Adult
Italy
Spain
colorectal cancer
diet
drinking water
nitrate
case-control studies
ISSN:0020-7136, 1097-0215, 1097-0215
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Ingested nitrate leads to the endogenous synthesis of N‐nitroso compounds (NOCs), animal carcinogens with limited human evidence. We aimed to evaluate the risk of colorectal cancer (CRC) associated with nitrate exposure in drinking water and diet. A case‐control study in Spain and Italy during 2008‐2013 was conducted. Hospital‐based incident cases and population‐based (Spain) or hospital‐based (Italy) controls were interviewed on residential history, water consumption since age 18, and dietary information. Long‐term waterborne ingested nitrate was derived from routine monitoring records, linked to subjects’ residential histories and water consumption habits. Dietary nitrate intake was estimated from food frequency questionnaires and published food composition databases. Odd ratios (OR) were calculated using mixed models with area as random effect, adjusted for CRC risk factors and other covariables. Generalized additive models (GAMs) were used to analyze exposure‐response relationships. Interaction with endogenous nitrosation factors and other covariables was also evaluated. In total 1,869 cases and 3,530 controls were analyzed. Average waterborne ingested nitrate ranged from 3.4 to 19.7 mg/day, among areas. OR (95% CIs) of CRC was 1.49 (1.24, 1.78) for >10 versus ≤5 mg/day, overall. Associations were larger among men versus women, and among subjects with high red meat intake. GAMs showed increasing exposure‐response relationship among men. Animal‐derived dietary nitrate was associated with rectal, but not with colon cancer risk. In conclusion, a positive association between CRC risk and waterborne ingested nitrate is suggested, mainly among subgroups with other risk factors. Heterogeneous effects of nitrate from different sources (water, animal and vegetables) warrant further research. What's new? Nitrate ingested in food and water can react with amines and amides in the gastrointestinal tract, leading to the formation of N‐nitroso compounds (NOCs), which are carcinogenic in animals. In humans, nitrate and several NOCs are probable carcinogens. The aim of the present investigation, a case–control study in Europe, was to examine links between nitrate intake and colorectal cancer (CRC). The findings indicate that CRC risk is increased for waterborne nitrate intake at levels below current international guidelines, particularly in subgroups with other risk factors. Nitrate intake from animal sources was further associated with increased rectal cancer risk.
Bibliografie:ORCID: 0000–0002‐0783–1259
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0020-7136
1097-0215
1097-0215
DOI:10.1002/ijc.30083