Colorectal cancer risk and nitrate exposure through drinking water and diet

Ingested nitrate leads to the endogenous synthesis of N‐nitroso compounds (NOCs), animal carcinogens with limited human evidence. We aimed to evaluate the risk of colorectal cancer (CRC) associated with nitrate exposure in drinking water and diet. A case‐control study in Spain and Italy during 2008‐...

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Bibliographic Details
Published in:	International journal of cancer Vol. 139; no. 2; pp. 334 - 346
Main Authors:	Espejo‐Herrera, Nadia, Gràcia‐Lavedan, Esther, Boldo, Elena, Aragonés, Nuria, Pérez‐Gómez, Beatriz, Pollán, Marina, Molina, Antonio J., Fernández, Tania, Martín, Vicente, La Vecchia, Carlo, Bosetti, Cristina, Tavani, Alessandra, Polesel, Jerry, Serraino, Diego, Gómez Acebo, Inés, Altzibar, Jone M., Ardanaz, Eva, Burgui, Rosana, Pisa, Federica, Fernández‐Tardón, Guillermo, Tardón, Adonina, Peiró, Rosana, Navarro, Carmen, Castaño‐Vinyals, Gemma, Moreno, Victor, Righi, Elena, Aggazzotti, Gabriella, Basagaña, Xavier, Nieuwenhuijsen, Mark, Kogevinas, Manolis, Villanueva, Cristina M.
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 15.07.2016 Wiley
Subjects:	Adult Age Aged Aged, 80 and over Amides Amines Cancer Carcinogens Case-Control Studies Colon cancer Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - epidemiology Colorectal Neoplasms - etiology Càncer Diet Diet - adverse effects Dietary intake Dose-response effects Drinking water Drinking Water - adverse effects Environmental Exposure - adverse effects Female Food composition Food intake Gastrointestinal tract Health risk assessment Humans Incidence Inventories Italy - epidemiology Male Meat Medical research Middle Aged N-Nitroso compounds Nitrate Nitrates Nitrates - adverse effects Nitrats Nitrosation Population Surveillance Recte Rectum Risk Risk factors Spain - epidemiology Vegetables Young Adult Italy Spain colorectal cancer diet drinking water nitrate case-control studies
ISSN:	0020-7136, 1097-0215, 1097-0215
Online Access:	Get full text
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