Intraosseous Vascular Access Is Associated With Lower Survival and Neurologic Recovery Among Patients With Out-of-Hospital Cardiac Arrest

We seek to determine the effect of intraosseous over intravenous vascular access on outcomes after out-of-hospital cardiac arrest. This secondary analysis of the Resuscitation Outcomes Consortium Prehospital Resuscitation Using an Impedance Valve and Early Versus Delayed (PRIMED) study included adul...

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Published in:	Annals of emergency medicine Vol. 71; no. 5; pp. 588 - 596
Main Authors:	Kawano, Takahisa, Grunau, Brian, Scheuermeyer, Frank X., Gibo, Koichiro, Fordyce, Christopher B., Lin, Steve, Stenstrom, Robert, Schlamp, Robert, Jenneson, Sandra, Christenson, Jim
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.05.2018
Subjects:	Aged Cardiopulmonary Resuscitation - methods Cardiopulmonary Resuscitation - mortality Clinical Competence Defibrillators Emergency Emergency Medical Services - methods Female Humans Infusions, Intraosseous - methods Infusions, Intraosseous - mortality Male Middle Aged Out-of-Hospital Cardiac Arrest - mortality Out-of-Hospital Cardiac Arrest - physiopathology Out-of-Hospital Cardiac Arrest - therapy Retrospective Studies Vascular Access Devices
ISSN:	0196-0644, 1097-6760, 1097-6760
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Abstract	We seek to determine the effect of intraosseous over intravenous vascular access on outcomes after out-of-hospital cardiac arrest. This secondary analysis of the Resuscitation Outcomes Consortium Prehospital Resuscitation Using an Impedance Valve and Early Versus Delayed (PRIMED) study included adult patients with nontraumatic out-of-hospital cardiac arrests treated during 2007 to 2009, excluding those with any unsuccessful attempt or more than one access site. The primary exposure was intraosseous versus intravenous vascular access. The primary outcome was favorable neurologic outcome on hospital discharge (modified Rankin Scale score ≤3). We determined the association between vascular access route and out-of-hospital cardiac arrest outcome with multivariable logistic regression, adjusting for age, sex, initial emergency medical services–recorded rhythm (shockable or nonshockable), witness status, bystander cardiopulmonary resuscitation, use of public automated external defibrillator, episode location (public or not), and time from call to paramedic scene arrival. We confirmed the results with multiple imputation, propensity score matching, and generalized estimating equations, with study enrolling region as a clustering variable. Of 13,155 included out-of-hospital cardiac arrests, 660 (5.0%) received intraosseous vascular access. In the intraosseous group, 10 of 660 patients (1.5%) had favorable neurologic outcome compared with 945 of 12,495 (7.6%) in the intravenous group. On multivariable regression, intraosseous access was associated with poorer out-of-hospital cardiac arrest survival (adjusted odds ratio 0.24; 95% confidence interval 0.12 to 0.46). Sensitivity analyses revealed similar results. In adult out-of-hospital cardiac arrest patients, intraosseous vascular access was associated with poorer neurologic outcomes than intravenous access.
AbstractList	We seek to determine the effect of intraosseous over intravenous vascular access on outcomes after out-of-hospital cardiac arrest. This secondary analysis of the Resuscitation Outcomes Consortium Prehospital Resuscitation Using an Impedance Valve and Early Versus Delayed (PRIMED) study included adult patients with nontraumatic out-of-hospital cardiac arrests treated during 2007 to 2009, excluding those with any unsuccessful attempt or more than one access site. The primary exposure was intraosseous versus intravenous vascular access. The primary outcome was favorable neurologic outcome on hospital discharge (modified Rankin Scale score ≤3). We determined the association between vascular access route and out-of-hospital cardiac arrest outcome with multivariable logistic regression, adjusting for age, sex, initial emergency medical services-recorded rhythm (shockable or nonshockable), witness status, bystander cardiopulmonary resuscitation, use of public automated external defibrillator, episode location (public or not), and time from call to paramedic scene arrival. We confirmed the results with multiple imputation, propensity score matching, and generalized estimating equations, with study enrolling region as a clustering variable. Of 13,155 included out-of-hospital cardiac arrests, 660 (5.0%) received intraosseous vascular access. In the intraosseous group, 10 of 660 patients (1.5%) had favorable neurologic outcome compared with 945 of 12,495 (7.6%) in the intravenous group. On multivariable regression, intraosseous access was associated with poorer out-of-hospital cardiac arrest survival (adjusted odds ratio 0.24; 95% confidence interval 0.12 to 0.46). Sensitivity analyses revealed similar results. In adult out-of-hospital cardiac arrest patients, intraosseous vascular access was associated with poorer neurologic outcomes than intravenous access. We seek to determine the effect of intraosseous over intravenous vascular access on outcomes after out-of-hospital cardiac arrest.STUDY OBJECTIVEWe seek to determine the effect of intraosseous over intravenous vascular access on outcomes after out-of-hospital cardiac arrest.This secondary analysis of the Resuscitation Outcomes Consortium Prehospital Resuscitation Using an Impedance Valve and Early Versus Delayed (PRIMED) study included adult patients with nontraumatic out-of-hospital cardiac arrests treated during 2007 to 2009, excluding those with any unsuccessful attempt or more than one access site. The primary exposure was intraosseous versus intravenous vascular access. The primary outcome was favorable neurologic outcome on hospital discharge (modified Rankin Scale score ≤3). We determined the association between vascular access route and out-of-hospital cardiac arrest outcome with multivariable logistic regression, adjusting for age, sex, initial emergency medical services-recorded rhythm (shockable or nonshockable), witness status, bystander cardiopulmonary resuscitation, use of public automated external defibrillator, episode location (public or not), and time from call to paramedic scene arrival. We confirmed the results with multiple imputation, propensity score matching, and generalized estimating equations, with study enrolling region as a clustering variable.METHODSThis secondary analysis of the Resuscitation Outcomes Consortium Prehospital Resuscitation Using an Impedance Valve and Early Versus Delayed (PRIMED) study included adult patients with nontraumatic out-of-hospital cardiac arrests treated during 2007 to 2009, excluding those with any unsuccessful attempt or more than one access site. The primary exposure was intraosseous versus intravenous vascular access. The primary outcome was favorable neurologic outcome on hospital discharge (modified Rankin Scale score ≤3). We determined the association between vascular access route and out-of-hospital cardiac arrest outcome with multivariable logistic regression, adjusting for age, sex, initial emergency medical services-recorded rhythm (shockable or nonshockable), witness status, bystander cardiopulmonary resuscitation, use of public automated external defibrillator, episode location (public or not), and time from call to paramedic scene arrival. We confirmed the results with multiple imputation, propensity score matching, and generalized estimating equations, with study enrolling region as a clustering variable.Of 13,155 included out-of-hospital cardiac arrests, 660 (5.0%) received intraosseous vascular access. In the intraosseous group, 10 of 660 patients (1.5%) had favorable neurologic outcome compared with 945 of 12,495 (7.6%) in the intravenous group. On multivariable regression, intraosseous access was associated with poorer out-of-hospital cardiac arrest survival (adjusted odds ratio 0.24; 95% confidence interval 0.12 to 0.46). Sensitivity analyses revealed similar results.RESULTSOf 13,155 included out-of-hospital cardiac arrests, 660 (5.0%) received intraosseous vascular access. In the intraosseous group, 10 of 660 patients (1.5%) had favorable neurologic outcome compared with 945 of 12,495 (7.6%) in the intravenous group. On multivariable regression, intraosseous access was associated with poorer out-of-hospital cardiac arrest survival (adjusted odds ratio 0.24; 95% confidence interval 0.12 to 0.46). Sensitivity analyses revealed similar results.In adult out-of-hospital cardiac arrest patients, intraosseous vascular access was associated with poorer neurologic outcomes than intravenous access.CONCLUSIONIn adult out-of-hospital cardiac arrest patients, intraosseous vascular access was associated with poorer neurologic outcomes than intravenous access. Study objectiveWe seek to determine the effect of intraosseous over intravenous vascular access on outcomes after out-of-hospital cardiac arrest. MethodsThis secondary analysis of the Resuscitation Outcomes Consortium Prehospital Resuscitation Using an Impedance Valve and Early Versus Delayed (PRIMED) study included adult patients with nontraumatic out-of-hospital cardiac arrests treated during 2007 to 2009, excluding those with any unsuccessful attempt or more than one access site. The primary exposure was intraosseous versus intravenous vascular access. The primary outcome was favorable neurologic outcome on hospital discharge (modified Rankin Scale score ≤3). We determined the association between vascular access route and out-of-hospital cardiac arrest outcome with multivariable logistic regression, adjusting for age, sex, initial emergency medical services–recorded rhythm (shockable or nonshockable), witness status, bystander cardiopulmonary resuscitation, use of public automated external defibrillator, episode location (public or not), and time from call to paramedic scene arrival. We confirmed the results with multiple imputation, propensity score matching, and generalized estimating equations, with study enrolling region as a clustering variable. ResultsOf 13,155 included out-of-hospital cardiac arrests, 660 (5.0%) received intraosseous vascular access. In the intraosseous group, 10 of 660 patients (1.5%) had favorable neurologic outcome compared with 945 of 12,495 (7.6%) in the intravenous group. On multivariable regression, intraosseous access was associated with poorer out-of-hospital cardiac arrest survival (adjusted odds ratio 0.24; 95% confidence interval 0.12 to 0.46). Sensitivity analyses revealed similar results. ConclusionIn adult out-of-hospital cardiac arrest patients, intraosseous vascular access was associated with poorer neurologic outcomes than intravenous access.
Author	Kawano, Takahisa Jenneson, Sandra Scheuermeyer, Frank X. Stenstrom, Robert Christenson, Jim Schlamp, Robert Fordyce, Christopher B. Grunau, Brian Gibo, Koichiro Lin, Steve
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Cites_doi	10.1056/NEJM196312262692603 10.1093/aje/kwf215 10.1016/j.resuscitation.2008.01.027 10.1186/s13054-016-1277-6 10.1016/j.resuscitation.2017.06.014 10.1197/j.aem.2005.09.011 10.1016/j.resuscitation.2011.07.041 10.1016/j.resuscitation.2008.01.028 10.1016/j.resuscitation.2015.10.011 10.1097/00003246-200108000-00015 10.1056/NEJMoa1514204 10.1213/ANE.0b013e31820dc9ec 10.1056/NEJM199909163411203 10.1056/NEJMoa1010821 10.1111/j.1553-2712.2007.tb01855.x 10.1016/0300-9572(94)90039-6 10.1016/S0895-4356(00)00321-8 10.1016/j.annemergmed.2011.07.020 10.1161/CIRCULATIONAHA.109.852202 10.1016/j.resuscitation.2014.11.002 10.1002/sim.7262 10.1016/j.ajem.2008.01.025 10.1056/NEJMoa1010076
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References	Orlowski, Porembka, Gallagher (bib22) 1990; 144 Kurz, Prince, Christenson (bib8) 2016; 98 Petitpas, Guenezan, Vendeuvre (bib2) 2016; 20 Hanley, Negassa, Edwardes (bib17) 2003; 157 Christenson, Andrusiek, Everson-Stewart (bib9) 2009; 120 Newgard, Haukoos (bib16) 2007; 14 Hoskins, do Nascimento, Lima (bib19) 2012; 83 Kudenchuk, Brown, Daya (bib27) 2016; 374 Kudenchuk, Cobb, Copass (bib11) 1999; 341 Delguercio, Coomaraswamy, State (bib24) 1963; 269 Zuercher, Kern, Indik (bib26) 2011; 112 Stiell, Nichol, Leroux (bib7) 2011; 365 Voelckel, Lurie, McKnite (bib23) 2001; 29 Ong, Chan, Oh (bib20) 2009; 27 Perkins, Jacobs, Nadkarni (bib10) 2015; 96 Sato, Okubo, Satsumae (bib25) 1994; 27 Normand, Landrum, Guadagnoli (bib13) 2001; 54 Aufderheide, Kudenchuk, Hedges (bib4) 2008; 78 Aufderheide, Nichol, Rea (bib5) 2011; 365 Haukoos, Newgard (bib14) 2007; 14 Stiell, Callaway, Davis (bib6) 2008; 78 Newgard (bib15) 2006; 13 Feinstein, Stubbs, Rea (bib21) 2017; 117 Feinstein, Stubbs, Rea (bib3) 2016; 117 Kudenchuk, Daya, Dorian (bib12) 2016; 375 Wang, Fu (bib18) 2017; 36 Reades, Studnek, Vandeventer (bib1) 2011; 58 Kudenchuk (10.1016/j.annemergmed.2017.11.015_bib12) 2016; 375 Sato (10.1016/j.annemergmed.2017.11.015_bib25) 1994; 27 Stiell (10.1016/j.annemergmed.2017.11.015_bib7) 2011; 365 Haukoos (10.1016/j.annemergmed.2017.11.015_bib14) 2007; 14 Perkins (10.1016/j.annemergmed.2017.11.015_bib10) 2015; 96 Hanley (10.1016/j.annemergmed.2017.11.015_bib17) 2003; 157 Feinstein (10.1016/j.annemergmed.2017.11.015_bib21) 2017; 117 Kurz (10.1016/j.annemergmed.2017.11.015_bib8) 2016; 98 Stiell (10.1016/j.annemergmed.2017.11.015_bib6) 2008; 78 Newgard (10.1016/j.annemergmed.2017.11.015_bib15) 2006; 13 Zuercher (10.1016/j.annemergmed.2017.11.015_bib26) 2011; 112 Newgard (10.1016/j.annemergmed.2017.11.015_bib16) 2007; 14 Delguercio (10.1016/j.annemergmed.2017.11.015_bib24) 1963; 269 Hoskins (10.1016/j.annemergmed.2017.11.015_bib19) 2012; 83 Kudenchuk (10.1016/j.annemergmed.2017.11.015_bib27) 2016; 374 Normand (10.1016/j.annemergmed.2017.11.015_bib13) 2001; 54 Orlowski (10.1016/j.annemergmed.2017.11.015_bib22) 1990; 144 Feinstein (10.1016/j.annemergmed.2017.11.015_bib3) 2016; 117 Ong (10.1016/j.annemergmed.2017.11.015_bib20) 2009; 27 Aufderheide (10.1016/j.annemergmed.2017.11.015_bib4) 2008; 78 Reades (10.1016/j.annemergmed.2017.11.015_bib1) 2011; 58 Petitpas (10.1016/j.annemergmed.2017.11.015_bib2) 2016; 20 Kudenchuk (10.1016/j.annemergmed.2017.11.015_bib11) 1999; 341 Voelckel (10.1016/j.annemergmed.2017.11.015_bib23) 2001; 29 Wang (10.1016/j.annemergmed.2017.11.015_bib18) 2017; 36 Aufderheide (10.1016/j.annemergmed.2017.11.015_bib5) 2011; 365 Christenson (10.1016/j.annemergmed.2017.11.015_bib9) 2009; 120 30031516 - Ann Emerg Med. 2018 Aug;72(2):229-231 29680406 - Ann Emerg Med. 2018 Aug;72(2):228-229
References_xml	– volume: 365 start-page: 798 year: 2011 end-page: 806 ident: bib5 article-title: A trial of an impedance threshold device in out-of-hospital cardiac arrest publication-title: N Engl J Med – volume: 365 start-page: 787 year: 2011 end-page: 797 ident: bib7 article-title: Early versus later rhythm analysis in patients with out-of-hospital cardiac arrest publication-title: N Engl J Med – volume: 58 start-page: 509 year: 2011 end-page: 516 ident: bib1 article-title: Intraosseous versus intravenous vascular access during out-of-hospital cardiac arrest: a randomized controlled trial publication-title: Ann Emerg Med – volume: 117 start-page: 91 year: 2016 end-page: 96 ident: bib3 article-title: Intraosseous compared to intravenous drug resuscitation in out-of-hospital cardiac arrest publication-title: Resuscitation – volume: 96 start-page: 328 year: 2015 end-page: 340 ident: bib10 article-title: Cardiac arrest and cardiopulmonary resuscitation outcome reports: update of the Utstein Resuscitation Registry templates for out-of-hospital cardiac arrest: a statement for healthcare professionals from a Task Force of the International Liaison Committee on Resuscitation (American Heart Association, European Resuscitation Council, Australian and New Zealand Council on Resuscitation, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Southern Africa, Resuscitation Council of Asia); and the American Heart Association Emergency Cardiovascular Care Committee and the Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation publication-title: Resuscitation – volume: 98 start-page: 35 year: 2016 end-page: 40 ident: bib8 article-title: Association of advanced airway device with chest compression fraction during out-of-hospital cardiopulmonary arrest publication-title: Resuscitation – volume: 157 start-page: 364 year: 2003 end-page: 375 ident: bib17 article-title: Statistical analysis of correlated data using generalized estimating equations: an orientation publication-title: Am J Epidemiol – volume: 112 start-page: 884 year: 2011 end-page: 890 ident: bib26 article-title: Epinephrine improves 24-hour survival in a swine model of prolonged ventricular fibrillation demonstrating that early intraosseous is superior to delayed intravenous administration publication-title: Anesth Analg – volume: 78 start-page: 186 year: 2008 end-page: 195 ident: bib6 article-title: Resuscitation Outcomes Consortium (ROC) PRIMED cardiac arrest trial methods part 2: rationale and methodology for “analyze later vs analyze early” protocol publication-title: Resuscitation – volume: 375 start-page: 802 year: 2016 end-page: 803 ident: bib12 article-title: Amiodarone, lidocaine, or placebo in out-of-hospital cardiac arrest publication-title: N Engl J Med – volume: 83 start-page: 107 year: 2012 end-page: 112 ident: bib19 article-title: Pharmacokinetics of intraosseous and central venous drug delivery during cardiopulmonary resuscitation publication-title: Resuscitation – volume: 144 start-page: 112 year: 1990 end-page: 117 ident: bib22 article-title: Comparison study of intraosseous, central intravenous, and peripheral intravenous infusions of emergency drugs publication-title: Am J Dis Child – volume: 78 start-page: 179 year: 2008 end-page: 185 ident: bib4 article-title: Resuscitation Outcomes Consortium (ROC) PRIMED cardiac arrest trial methods part 1: rationale and methodology for the impedance threshold device (ITD) protocol publication-title: Resuscitation – volume: 54 start-page: 387 year: 2001 end-page: 398 ident: bib13 article-title: Validating recommendations for coronary angiography following acute myocardial infarction in the elderly: a matched analysis using propensity scores publication-title: J Clin Epidemiol – volume: 269 start-page: 1398 year: 1963 end-page: 1404 ident: bib24 article-title: Cardiac output and other hemodynamic variables during external cardiac massage in man publication-title: N Engl J Med – volume: 374 start-page: 1711 year: 2016 end-page: 1722 ident: bib27 article-title: Amiodarone, lidocaine, or placebo in out-of-hospital cardiac arrest publication-title: N Engl J Med – volume: 20 start-page: 102 year: 2016 ident: bib2 article-title: Use of intra-osseous access in adults: a systematic review publication-title: Crit Care – volume: 14 start-page: 662 year: 2007 end-page: 668 ident: bib14 article-title: Advanced statistics: missing data in clinical research—part 1: an introduction and conceptual framework publication-title: Acad Emerg Med – volume: 14 start-page: 669 year: 2007 end-page: 678 ident: bib16 article-title: Advanced statistics: missing data in clinical research—part 2: multiple imputation publication-title: Acad Emerg Med – volume: 36 start-page: 2206 year: 2017 end-page: 2219 ident: bib18 article-title: Selection of working correlation structure in generalized estimating equations publication-title: Stat Med – volume: 27 start-page: 255 year: 1994 end-page: 259 ident: bib25 article-title: Arteriovenous differences in PCO publication-title: Resuscitation – volume: 29 start-page: 1587 year: 2001 end-page: 1592 ident: bib23 article-title: Comparison of epinephrine with vasopressin on bone marrow blood flow in an animal model of hypovolemic shock and subsequent cardiac arrest publication-title: Crit Care Med – volume: 13 start-page: 314 year: 2006 end-page: 324 ident: bib15 article-title: The validity of using multiple imputation for missing out-of-hospital data in a state trauma registry publication-title: Acad Emerg Med – volume: 341 start-page: 871 year: 1999 end-page: 878 ident: bib11 article-title: Amiodarone for resuscitation after out-of-hospital cardiac arrest due to ventricular fibrillation publication-title: N Engl J Med – volume: 117 start-page: 91 year: 2017 end-page: 96 ident: bib21 article-title: Intraosseous compared to intravenous drug resuscitation in out-of-hospital cardiac arrest publication-title: Resuscitation – volume: 120 start-page: 1241 year: 2009 end-page: 1247 ident: bib9 article-title: Chest compression fraction determines survival in patients with out-of-hospital ventricular fibrillation publication-title: Circulation – volume: 27 start-page: 8 year: 2009 end-page: 15 ident: bib20 article-title: An observational, prospective study comparing tibial and humeral intraosseous access using the EZ-IO publication-title: Am J Emerg Med – volume: 269 start-page: 1398 year: 1963 ident: 10.1016/j.annemergmed.2017.11.015_bib24 article-title: Cardiac output and other hemodynamic variables during external cardiac massage in man publication-title: N Engl J Med doi: 10.1056/NEJM196312262692603 – volume: 157 start-page: 364 year: 2003 ident: 10.1016/j.annemergmed.2017.11.015_bib17 article-title: Statistical analysis of correlated data using generalized estimating equations: an orientation publication-title: Am J Epidemiol doi: 10.1093/aje/kwf215 – volume: 78 start-page: 186 year: 2008 ident: 10.1016/j.annemergmed.2017.11.015_bib6 article-title: Resuscitation Outcomes Consortium (ROC) PRIMED cardiac arrest trial methods part 2: rationale and methodology for “analyze later vs analyze early” protocol publication-title: Resuscitation doi: 10.1016/j.resuscitation.2008.01.027 – volume: 20 start-page: 102 year: 2016 ident: 10.1016/j.annemergmed.2017.11.015_bib2 article-title: Use of intra-osseous access in adults: a systematic review publication-title: Crit Care doi: 10.1186/s13054-016-1277-6 – volume: 117 start-page: 91 year: 2016 ident: 10.1016/j.annemergmed.2017.11.015_bib3 article-title: Intraosseous compared to intravenous drug resuscitation in out-of-hospital cardiac arrest publication-title: Resuscitation doi: 10.1016/j.resuscitation.2017.06.014 – volume: 13 start-page: 314 year: 2006 ident: 10.1016/j.annemergmed.2017.11.015_bib15 article-title: The validity of using multiple imputation for missing out-of-hospital data in a state trauma registry publication-title: Acad Emerg Med doi: 10.1197/j.aem.2005.09.011 – volume: 83 start-page: 107 year: 2012 ident: 10.1016/j.annemergmed.2017.11.015_bib19 article-title: Pharmacokinetics of intraosseous and central venous drug delivery during cardiopulmonary resuscitation publication-title: Resuscitation doi: 10.1016/j.resuscitation.2011.07.041 – volume: 78 start-page: 179 year: 2008 ident: 10.1016/j.annemergmed.2017.11.015_bib4 article-title: Resuscitation Outcomes Consortium (ROC) PRIMED cardiac arrest trial methods part 1: rationale and methodology for the impedance threshold device (ITD) protocol publication-title: Resuscitation doi: 10.1016/j.resuscitation.2008.01.028 – volume: 117 start-page: 91 year: 2017 ident: 10.1016/j.annemergmed.2017.11.015_bib21 article-title: Intraosseous compared to intravenous drug resuscitation in out-of-hospital cardiac arrest publication-title: Resuscitation doi: 10.1016/j.resuscitation.2017.06.014 – volume: 98 start-page: 35 year: 2016 ident: 10.1016/j.annemergmed.2017.11.015_bib8 article-title: Association of advanced airway device with chest compression fraction during out-of-hospital cardiopulmonary arrest publication-title: Resuscitation doi: 10.1016/j.resuscitation.2015.10.011 – volume: 144 start-page: 112 year: 1990 ident: 10.1016/j.annemergmed.2017.11.015_bib22 article-title: Comparison study of intraosseous, central intravenous, and peripheral intravenous infusions of emergency drugs publication-title: Am J Dis Child – volume: 29 start-page: 1587 year: 2001 ident: 10.1016/j.annemergmed.2017.11.015_bib23 article-title: Comparison of epinephrine with vasopressin on bone marrow blood flow in an animal model of hypovolemic shock and subsequent cardiac arrest publication-title: Crit Care Med doi: 10.1097/00003246-200108000-00015 – volume: 374 start-page: 1711 year: 2016 ident: 10.1016/j.annemergmed.2017.11.015_bib27 article-title: Amiodarone, lidocaine, or placebo in out-of-hospital cardiac arrest publication-title: N Engl J Med doi: 10.1056/NEJMoa1514204 – volume: 112 start-page: 884 year: 2011 ident: 10.1016/j.annemergmed.2017.11.015_bib26 article-title: Epinephrine improves 24-hour survival in a swine model of prolonged ventricular fibrillation demonstrating that early intraosseous is superior to delayed intravenous administration publication-title: Anesth Analg doi: 10.1213/ANE.0b013e31820dc9ec – volume: 341 start-page: 871 year: 1999 ident: 10.1016/j.annemergmed.2017.11.015_bib11 article-title: Amiodarone for resuscitation after out-of-hospital cardiac arrest due to ventricular fibrillation publication-title: N Engl J Med doi: 10.1056/NEJM199909163411203 – volume: 365 start-page: 798 year: 2011 ident: 10.1016/j.annemergmed.2017.11.015_bib5 article-title: A trial of an impedance threshold device in out-of-hospital cardiac arrest publication-title: N Engl J Med doi: 10.1056/NEJMoa1010821 – volume: 14 start-page: 662 year: 2007 ident: 10.1016/j.annemergmed.2017.11.015_bib14 article-title: Advanced statistics: missing data in clinical research—part 1: an introduction and conceptual framework publication-title: Acad Emerg Med doi: 10.1111/j.1553-2712.2007.tb01855.x – volume: 27 start-page: 255 year: 1994 ident: 10.1016/j.annemergmed.2017.11.015_bib25 article-title: Arteriovenous differences in PCO2 and cardiac output during CPR in the dog publication-title: Resuscitation doi: 10.1016/0300-9572(94)90039-6 – volume: 54 start-page: 387 year: 2001 ident: 10.1016/j.annemergmed.2017.11.015_bib13 article-title: Validating recommendations for coronary angiography following acute myocardial infarction in the elderly: a matched analysis using propensity scores publication-title: J Clin Epidemiol doi: 10.1016/S0895-4356(00)00321-8 – volume: 14 start-page: 669 year: 2007 ident: 10.1016/j.annemergmed.2017.11.015_bib16 article-title: Advanced statistics: missing data in clinical research—part 2: multiple imputation publication-title: Acad Emerg Med – volume: 58 start-page: 509 year: 2011 ident: 10.1016/j.annemergmed.2017.11.015_bib1 article-title: Intraosseous versus intravenous vascular access during out-of-hospital cardiac arrest: a randomized controlled trial publication-title: Ann Emerg Med doi: 10.1016/j.annemergmed.2011.07.020 – volume: 120 start-page: 1241 year: 2009 ident: 10.1016/j.annemergmed.2017.11.015_bib9 article-title: Chest compression fraction determines survival in patients with out-of-hospital ventricular fibrillation publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.109.852202 – volume: 96 start-page: 328 year: 2015 ident: 10.1016/j.annemergmed.2017.11.015_bib10 publication-title: Resuscitation doi: 10.1016/j.resuscitation.2014.11.002 – volume: 36 start-page: 2206 year: 2017 ident: 10.1016/j.annemergmed.2017.11.015_bib18 article-title: Selection of working correlation structure in generalized estimating equations publication-title: Stat Med doi: 10.1002/sim.7262 – volume: 375 start-page: 802 year: 2016 ident: 10.1016/j.annemergmed.2017.11.015_bib12 article-title: Amiodarone, lidocaine, or placebo in out-of-hospital cardiac arrest publication-title: N Engl J Med – volume: 27 start-page: 8 year: 2009 ident: 10.1016/j.annemergmed.2017.11.015_bib20 article-title: An observational, prospective study comparing tibial and humeral intraosseous access using the EZ-IO publication-title: Am J Emerg Med doi: 10.1016/j.ajem.2008.01.025 – volume: 365 start-page: 787 year: 2011 ident: 10.1016/j.annemergmed.2017.11.015_bib7 article-title: Early versus later rhythm analysis in patients with out-of-hospital cardiac arrest publication-title: N Engl J Med doi: 10.1056/NEJMoa1010076 – reference: 30031516 - Ann Emerg Med. 2018 Aug;72(2):229-231 – reference: 29680406 - Ann Emerg Med. 2018 Aug;72(2):228-229
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Snippet	We seek to determine the effect of intraosseous over intravenous vascular access on outcomes after out-of-hospital cardiac arrest. This secondary analysis of... Study objectiveWe seek to determine the effect of intraosseous over intravenous vascular access on outcomes after out-of-hospital cardiac arrest. MethodsThis... We seek to determine the effect of intraosseous over intravenous vascular access on outcomes after out-of-hospital cardiac arrest.STUDY OBJECTIVEWe seek to...
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SubjectTerms	Aged Cardiopulmonary Resuscitation - methods Cardiopulmonary Resuscitation - mortality Clinical Competence Defibrillators Emergency Emergency Medical Services - methods Female Humans Infusions, Intraosseous - methods Infusions, Intraosseous - mortality Male Middle Aged Out-of-Hospital Cardiac Arrest - mortality Out-of-Hospital Cardiac Arrest - physiopathology Out-of-Hospital Cardiac Arrest - therapy Retrospective Studies Vascular Access Devices
Title	Intraosseous Vascular Access Is Associated With Lower Survival and Neurologic Recovery Among Patients With Out-of-Hospital Cardiac Arrest
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