The role of long noncoding RNA SNHG7 in human cancers (Review)

Long non-coding RNAs (lncRNAs) have been demonstrated to serve important roles in a variety of human tumor types. The lncRNA small nucleolar RNA host gene 7 (SNHG7) is associated with a variety of cancer types, such as esophageal cancer, breast cancer and gastric neoplasia. Based on previous studies...

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Published in:Molecular and clinical oncology Vol. 13; no. 5; p. 1
Main Authors: Bian, Zheng, Ji, Wei, Xu, Bing, Huang, Weiyi, Jiao, Jiantong, Shao, Junfei, Zhang, Xiaolu
Format: Journal Article
Language:English
Published: Athens D.A. Spandidos 01.11.2020
Spandidos Publications
Spandidos Publications UK Ltd
Subjects:
Antisense RNA
Apoptosis
biomarker
Breast cancer
Cancer diagnosis
Cancer metastasis
Cancer research
Cancer therapies
cancers
Cell adhesion & migration
Cell cycle
Cell growth
Development and progression
DNA methylation
Epigenetics
Esophageal cancer
Gastric cancer
Genes
Genetic aspects
long non-coding RNA
Lung cancer
Lymphatic system
Medical diagnosis
Medical prognosis
Metastasis
MicroRNA
MicroRNAs
Oncology
Patients
Prostate
Review
RNA polymerase
small nucleolar RNA host gene 7
Tumors
Canada
ISSN:2049-9450, 2049-9469
Online Access:Get full text
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Summary:Long non-coding RNAs (lncRNAs) have been demonstrated to serve important roles in a variety of human tumor types. The lncRNA small nucleolar RNA host gene 7 (SNHG7) is associated with a variety of cancer types, such as esophageal cancer, breast cancer and gastric neoplasia. Based on previous studies that examined SNHG7 expression in tumors, it has become clear that SNHG7 modulates tumorigenesis and cancer progression by acting as a competing endogenous RNA. SNHG7 can sponge tumor-suppressive microRNAs and regulate downstream signaling pathways. In addition, overexpression of SNHG7 is associated with the clinical characteristics of patients with cancer by regulating cellular proliferation, invasion and metastasis and by inhibiting apoptosis via a variety of mechanisms of action. The function of SNHG7 in tumorigenesis and cancer progression indicates that it can potentially act as a novel therapeutic target or a diagnostic biomarker for cancer therapy or detection, respectively.
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Contributed equally
ISSN:2049-9450
2049-9469
DOI:10.3892/mco.2020.2115