Inhibition of Respiration of Candida albicans by Small Molecules Increases Phagocytosis Efficacy by Macrophages

The yeast Candida albicans is one of the major fungal human pathogens, for which new therapeutic approaches are required. We aimed at enhancements of the phagocytosis efficacy of macrophages by targeting the cell wall structure of C. albicans , as the coverage of the β-glucan layer by mannans is one...

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Bibliographic Details
Published in:	mSphere Vol. 5; no. 2
Main Authors:	Cui, Shuna, Li, Minghui, Hassan, Rabeay Y. A., Heintz-Buschart, Anna, Wang, Junsong, Bilitewski, Ursula
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 15.04.2020
Subjects:	Animals Antifungal Agents - pharmacology Antimycin A Antimycin A - pharmacology Candida albicans Candida albicans - drug effects Candida albicans - metabolism Cell walls Cells, Cultured complex III Efficiency Electron Transport Energy Metabolism Ergosterol Experiments Fatty acids Fungi Gene expression Glucans Host-pathogen interactions Immune system Influence Kinases Macrophages Macrophages - microbiology Metabolic pathways metabolism Mice Mitochondria Pathogenicity Pathogens Phagocytes Phagocytosis Protein biosynthesis Proteins RAW 264.7 Cells Reactive oxygen species Respiration respiratory chain Signal transduction Standard deviation Therapeutics and Prevention β-Glucan antimycin A phagocytosis metabolism complex III respiratory chain
ISSN:	2379-5042, 2379-5042
Online Access:	Get full text
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